CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.

Cat. No.	Product name	CAS No.	Purity
T12269	NUCC-390	1060524-97-1	98.18%
T12269	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compou...
T11693L	IT1t dihydrochloride	1092776-63-0	98.03%
T11693L	IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
T5193	Danirixin	954126-98-8	98%
T5193	Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
T7130	Navarixin	473727-83-2	98%
T7130	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil traf...
T4163	Reparixin	266359-83-5	98%
T4163	Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly...
T26035	Rac-NBI-74330	473722-68-8	97.85%
T26035	rac-NBI-74330 is an effective and selective CXCR3 antagonist.
T16850	SB-265610	211096-49-0	97.67%
T16850	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calciu...
T15805L	LY2510924 acetate(1088715-84-7 free base)	T15805L	97.32%
T15805L	Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
T12705	Reparixin L-lysine salt	266359-93-7	97.31%
T12705	Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T6764L	ATI-2341 acetate(1337878-62-2 free base)	T6764L	97.14%
T6764L	ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (G...
T3992	MSX-122	897657-95-3	97.02%
T3992	MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
T1955	SB225002	182498-32-4	96.86%
T1955	SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
T11179	Elubrixin	688763-64-6	100.00%
T11179	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory disea...
T1776	Plerixafor	110078-46-1	100%
T1776	Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
T5849	JMS-17-2	1380392-05-1
T5849	JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
T9721	ML339	2579689-83-9	98%
T9721	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
TP2112L	TC14012 acetate	TP2112L	98%
TP2112L	TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
T14384	AZD8797	911715-90-7	98%
T14384	AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially pr...
TQ0174	Mavorixafor	558447-26-0	98%
TQ0174	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the rep...
T76662	Ac-Pro-Gly-Pro-OH	292171-04-1	98%
T76662	Ac-Pro-Gly-Pro-OH is an acetyl-modified tripeptide compound that acts as a CXCR2 agonist.Ac-Pro-Gly-Pro-OH exhibits bactericidal and anti-inflammatory activity, ...