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Search Results for " calcium-channel "

Targets

340

Compounds

44

Natural Products

18

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T77710 Calcium Channel antagonist 2 WAY-327363 Calcium Channel
Calcium Channel antagonist 2 is a calcium channel antagonist (IC50=5-20 μM) that can be used to study diseases due to Ca2+ channels like pain and diabetes.
T10101 Calcium channel-modulator-1 Others , Calcium Channel
Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.
T77711 Calcium Channel antagonist 4 Calcium Channel
Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).
T77712 Calcium Channel antagonist 3 Calcium Channel
Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).
T12153 N-type calcium channel blocker-1 Calcium Channel
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
T2519 Lercanidipine Masnidipine Calcium Channel
Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class.
T10659 Ca2+ channel agonist 1 Calcium Channel , CDK
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.
T8944 TTA-A2 Calcium Channel
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...
T12015 Methyl homoveratrate Others
Methyl homoveratrate, a metabolite of McN5691 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker.
T7603 Pinaverium bromide Calcium Channel
Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
T1530 Mitiglinide calcium hydrate KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate Potassium Channel
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ...
T11353 Gallopamil Methoxyverapamil Calcium Channel
Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy der...
T0283 Trimethadione 3,5,5,-Trimethyloxazolidine-2,4-dione Calcium Channel
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.
T8863 VK-II-36 Others
VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor.
T15423 GSK-7975A Calcium Channel
GSK-7975A is a potent and orally available inhibitor of CRAC channel.
T0119 Nitrendipine BAY-E-5009,Bayotensin Calcium Channel , Autophagy
Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtr...
T0957 Isradipine PN 200-110 Calcium Channel , Autophagy
Isradipine (PN 200-110) is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calcium ion channels of coronary and peripheral vasc...
T11353L Gallopamil hydrochloride Methoxyverapamil hydrochloride Calcium Channel
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.
T23280 Ruthenium Red Ammoniated ruthenium oxychloride Calcium Channel
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ...
T10690 Cav 2.2 blocker 1 Calcium Channel
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.
T6874 Lercanidipine hydrochloride Corifeo,Carmen,Cardiovasc Calcium Channel
Lercanidipine hydrochloride (Corifeo) is a calcium channel blocker of the dihydropyridine class.
T5023 Propiverine hydrochloride Others , Calcium Channel , AChR
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).
T64203 T-Type calcium channel inhibitor 2
T-Type calcium channel inhibitor 2 (compound 6g) is a potent inhibitor of the T-type calcium channel, acting on Cav3.1 (α1G) (IC50: 31.0 μM), Cav3.2 (α1H) (IC50: 83.1 μM), Cav3.3 (α1I) (α1H) ( T-Type calcium channel inhi...
T8674 SR33805 Calcium Channel
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
T13047 Synta66 Calcium Channel
Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.
T11517 GV-58 Calcium Channel
GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.
T7373 CDN1163 Calcium Channel
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).
T12608 QX-314 chloride Sodium Channel
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T3543 NS-638 NS 638 Calcium Channel
NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
T3703 ABT-639 ABT 639 Calcium Channel
ABT-639 is a potent and selective T-type calcium channel blocker.
T0030 Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl Sodium Channel
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...
T0343 Nimodipine BAY-e 9736 Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T16014 Mavatrep JNJ-39439335 TRP/TRPV Channel
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.
T22788 FPL64176 FPL 64176 Calcium Channel
FPL64176 is a L-type calcium channels activator.
T0916 Butamben Butyl 4-aminobenzoate Potassium Channel , Calcium Channel , Sodium Channel
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
T1198 Tetracaine hydrochloride Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl Calcium Channel , Sodium Channel
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use...
T7216 Mirogabalin DS5565 Calcium Channel
Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects.
T1510 Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T0388 Cilnidipine FRC-8653 Calcium Channel
Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
T6848 GSK1016790A GSK101 Calcium Channel , TRP/TRPV Channel
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
T29201 Z944 Z 944,Z-944 Calcium Channel
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.
T5632 Suvecaltamide MK-8998 Calcium Channel
Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels.
T0702 Gabapentin Neurontin,Gabapentine,Aclonium Calcium Channel , GABA Receptor
Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0858 Flufenamic acid Arlef,Nichisedan,Achless Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T6577 Manidipine Iperten,Franidipine,Artedil Calcium Channel
Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized
T0327 Fendiline hydrochloride Fendiline HCl Calcium Channel
Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.
T10885 CRAC intermediate 2 Others , Calcium Channel
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis.
T5376 Aranidipine MPC1304 Calcium Channel
Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
T8815 Azumolene EU4093 free base Calcium Channel
Azumolene (EU4093 free base)
T0903 Cinnarizine Stugeron,Cinarizine,Dimitronal,Stutgin Calcium Channel , Histamine Receptor
Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.

Compounds

Calcium Channel antagonist 2
T77710
Synonym: WAY-327363
Target: Calcium Channel
Calcium channel-modulator-1
T10101
Synonym:
Target: Others, Calcium Channel
Calcium Channel antagonist 4
T77711
Synonym:
Target: Calcium Channel
Calcium Channel antagonist 3
T77712
Synonym:
Target: Calcium Channel
N-type calcium channel blocker-1
T12153
Synonym:
Target: Calcium Channel
Lercanidipine
T2519
Synonym: Masnidipine
Target: Calcium Channel
Ca2+ channel agonist 1
T10659
Synonym:
Target: Calcium Channel, CDK
TTA-A2
T8944
Synonym:
Target: Calcium Channel
Methyl homoveratrate
T12015
Synonym:
Target: Others
Pinaverium bromide
T7603
Synonym:
Target: Calcium Channel
Mitiglinide calcium hydrate
T1530
Synonym: KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate
Target: Potassium Channel
Gallopamil
T11353
Synonym: Methoxyverapamil
Target: Calcium Channel
Trimethadione
T0283
Synonym: 3,5,5,-Trimethyloxazolidine-2,4-dione
Target: Calcium Channel
VK-II-36
T8863
Synonym:
Target: Others
GSK-7975A
T15423
Synonym:
Target: Calcium Channel
Nitrendipine
T0119
Synonym: BAY-E-5009,Bayotensin
Target: Calcium Channel, Autophagy
Isradipine
T0957
Synonym: PN 200-110
Target: Calcium Channel, Autophagy
Gallopamil hydrochloride
T11353L
Synonym: Methoxyverapamil hydrochloride
Target: Calcium Channel
Ruthenium Red
T23280
Synonym: Ammoniated ruthenium oxychloride
Target: Calcium Channel
Cav 2.2 blocker 1
T10690
Synonym:
Target: Calcium Channel
Lercanidipine hydrochloride
T6874
Synonym: Corifeo,Carmen,Cardiovasc
Target: Calcium Channel
Propiverine hydrochloride
T5023
Synonym:
Target: Others, Calcium Channel, AChR
T-Type calcium channel inhibitor 2
T64203
Synonym:
Target:
SR33805
T8674
Synonym:
Target: Calcium Channel
Synta66
T13047
Synonym:
Target: Calcium Channel
GV-58
T11517
Synonym:
Target: Calcium Channel
CDN1163
T7373
Synonym:
Target: Calcium Channel
QX-314 chloride
T12608
Synonym:
Target: Sodium Channel
NS-638
T3543
Synonym: NS 638
Target: Calcium Channel
ABT-639
T3703
Synonym: ABT 639
Target: Calcium Channel
Bupivacaine hydrochloride
T0030
Synonym: Vivacaine,Bupivacaine HCl
Target: Sodium Channel
Nimodipine
T0343
Synonym: BAY-e 9736
Target: Glucocorticoid Receptor, AhR, Calcium Channel, Autophagy
Mavatrep
T16014
Synonym: JNJ-39439335
Target: TRP/TRPV Channel
FPL64176
T22788
Synonym: FPL 64176
Target: Calcium Channel
Butamben
T0916
Synonym: Butyl 4-aminobenzoate
Target: Potassium Channel, Calcium Channel, Sodium Channel
Tetracaine hydrochloride
T1198
Synonym: Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl
Target: Calcium Channel, Sodium Channel
Mirogabalin
T7216
Synonym: DS5565
Target: Calcium Channel
Rosuvastatin calcium
T1510
Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium
Target: Potassium Channel, HMG-CoA Reductase, Autophagy
Cilnidipine
T0388
Synonym: FRC-8653
Target: Calcium Channel
GSK1016790A
T6848
Synonym: GSK101
Target: Calcium Channel, TRP/TRPV Channel
Z944
T29201
Synonym: Z 944,Z-944
Target: Calcium Channel
Suvecaltamide
T5632
Synonym: MK-8998
Target: Calcium Channel
Gabapentin
T0702
Synonym: Neurontin,Gabapentine,Aclonium
Target: Calcium Channel, GABA Receptor
Flufenamic acid
T0858
Synonym: Arlef,Nichisedan,Achless
Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite
Manidipine
T6577
Synonym: Iperten,Franidipine,Artedil
Target: Calcium Channel
Fendiline hydrochloride
T0327
Synonym: Fendiline HCl
Target: Calcium Channel
CRAC intermediate 2
T10885
Synonym:
Target: Others, Calcium Channel
Aranidipine
T5376
Synonym: MPC1304
Target: Calcium Channel
Azumolene
T8815
Synonym: EU4093 free base
Target: Calcium Channel
Cinnarizine
T0903
Synonym: Stugeron,Cinarizine,Dimitronal,Stutgin
Target: Calcium Channel, Histamine Receptor
1 2 3 4 5 6 7
Cat No. Product Name Synonyms Targets
T8206 Cycleanine Others
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.
TN2322 Yangambin Calcium Channel , PAFR
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...
T11665 Ionomycin calcium SQ23377 calcium Apoptosis , Calcium Channel , Antibacterial , Antibiotic , PKC
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly spec...
T6S1418 Praeruptorin C Antioxidant , Calcium Channel
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...
T8787 Drotaverine hydrochloride PDE
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...
T0728 Ethosuximide Zarontin Calcium Channel
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
T3904 Gomisin J Calcium Channel , AMPK
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...
TN1008 Psoralenoside CaMK , Calcium Channel , Histamine Receptor
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
T5723 Menthol DL-Menthol Others , Calcium Channel
Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.
T15027 Cyclopiazonic acid Calcium Channel
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce...
T4S1422 Praeruptorin E Others , Calcium Channel
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...
TQ0302 Thapsigargin Apoptosis , SARS-CoV , Calcium Channel
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
T3013 Catharanthine tartrate Catharanthine hemitartrate Others , Calcium Channel
Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities.
T2782 Catharanthine (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine Calcium Channel , AChR
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
T6S1500 Ginsenoside Rf Ginsenoside-Rf,Panaxoside Rf Calcium Channel , Endogenous Metabolite
Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
T4590 (+)-Kavain Kavain,L-KAWAIN,(R)-KAWAIN Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T10024 1-Octanol Octanol Calcium Channel , Endogenous Metabolite
1-Octanol (Octanol) (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like prope...
T4727 Taurolithocholic acid sodium salt Sodium taurolithocholate Others , Calcium Channel
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.
TN7108 Urolithin C Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T4S1419 (±)-Praeruptorin A Praeruptorin A,(-)-Praeruptorin A p38 MAPK , Calcium Channel , Akt
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ...
T3S1916 Heteroclitin D Calcium Channel
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor.
T5701 OPHIOPOGONIN D RAAS , Calcium Channel , NF-κB , PPAR
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
T2996 Tetrandrine NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A Potassium Channel , Calcium Channel
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c...
T7056 Dronedarone SR 33589 P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T1221 Acetylcholine chloride ACh chloride,Pilofrin Calcium Channel , Endogenous Metabolite , AChR
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...
T8288 14-Deoxyandrographolide Apoptosis , Others
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T5S2059 Glaucine Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T0928 L-Ascorbic acid Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
L-Ascorbic acid (Vitamin C) is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen.
T3915 Ginsenoside Ro Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V Calcium Channel , Reductase , Prostaglandin Receptor
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.
T2878 Ginsenoside Rd Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T3377 L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine Calcium Channel , Endogenous Metabolite , iGluR
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
T2946 Tanshinone IIA sulfonate sodium Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium CaMK , P450 , Calcium Channel
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...
T6674 L-Ascorbic acid sodium salt (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T23735 Jamaicin An-Co-A4,AnCoA-4,An Co A4,AnCoA4 Calcium Channel
Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation.
T0792 (-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate Sodium Channel
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T1062 Capsaicin Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,Vanilloid,(E)-Capsaicin,Zostrix Apoptosis , TRP/TRPV Channel , Autophagy
Capsaicin ((E)-Capsaicin) is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This is why capsaicin is linked...
T3S0807 Berbamine CaMK , NF-κB , Autophagy
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.
T3929 Kaurenoic acid Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid Others
Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,...
T3S0209 Vincristine ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato...
T2163 Dihydrocapsaicin CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide Others , TRP/TRPV Channel
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...
TMA0763 Methyl 3,4,5-trimethoxycinnamate Potassium Channel , Calcium Channel
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
T3029 Sparteine sulfate Depasan,Tocosimplex,Actospar Others , Sodium Channel
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.

Natural Products

Cycleanine
T8206
Synonym:
Target: Others
Yangambin
TN2322
Synonym:
Target: Calcium Channel, PAFR
Ionomycin calcium
T11665
Synonym: SQ23377 calcium
Target: Apoptosis, Calcium Channel, Antibacterial, Antibiotic, PKC
Praeruptorin C
T6S1418
Synonym:
Target: Antioxidant, Calcium Channel
Drotaverine hydrochloride
T8787
Synonym:
Target: PDE
Ethosuximide
T0728
Synonym: Zarontin
Target: Calcium Channel
Gomisin J
T3904
Synonym:
Target: Calcium Channel, AMPK
Psoralenoside
TN1008
Synonym:
Target: CaMK, Calcium Channel, Histamine Receptor
Menthol
T5723
Synonym: DL-Menthol
Target: Others, Calcium Channel
Cyclopiazonic acid
T15027
Synonym:
Target: Calcium Channel
Praeruptorin E
T4S1422
Synonym:
Target: Others, Calcium Channel
Thapsigargin
TQ0302
Synonym:
Target: Apoptosis, SARS-CoV, Calcium Channel
Catharanthine tartrate
T3013
Synonym: Catharanthine hemitartrate
Target: Others, Calcium Channel
Catharanthine
T2782
Synonym: (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine
Target: Calcium Channel, AChR
Ginsenoside Rf
T6S1500
Synonym: Ginsenoside-Rf,Panaxoside Rf
Target: Calcium Channel, Endogenous Metabolite
(+)-Kavain
T4590
Synonym: Kavain,L-KAWAIN,(R)-KAWAIN
Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter
1-Octanol
T10024
Synonym: Octanol
Target: Calcium Channel, Endogenous Metabolite
Taurolithocholic acid sodium salt
T4727
Synonym: Sodium taurolithocholate
Target: Others, Calcium Channel
Urolithin C
TN7108
Synonym:
Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite
(±)-Praeruptorin A
T4S1419
Synonym: Praeruptorin A,(-)-Praeruptorin A
Target: p38 MAPK, Calcium Channel, Akt
Heteroclitin D
T3S1916
Synonym:
Target: Calcium Channel
OPHIOPOGONIN D
T5701
Synonym:
Target: RAAS, Calcium Channel, NF-κB, PPAR
Tetrandrine
T2996
Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A
Target: Potassium Channel, Calcium Channel
Dronedarone
T7056
Synonym: SR 33589
Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy
Acetylcholine chloride
T1221
Synonym: ACh chloride,Pilofrin
Target: Calcium Channel, Endogenous Metabolite, AChR
14-Deoxyandrographolide
T8288
Synonym:
Target: Apoptosis, Others
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Glaucine
T5S2059
Synonym:
Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE
L-Ascorbic acid
T0928
Synonym: Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate
Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite
Ginsenoside Ro
T3915
Synonym: Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V
Target: Calcium Channel, Reductase, Prostaglandin Receptor
Ginsenoside Rd
T2878
Synonym: Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII
Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite
L-Phenylalanine
T3377
Synonym: (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine
Target: Calcium Channel, Endogenous Metabolite, iGluR
Tanshinone IIA sulfonate sodium
T2946
Synonym: Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium
Target: CaMK, P450, Calcium Channel
L-Ascorbic acid sodium salt
T6674
Synonym: (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate
Target: Apoptosis, Others, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Jamaicin
T23735
Synonym: An-Co-A4,AnCoA-4,An Co A4,AnCoA4
Target: Calcium Channel
(-)-Sparteine sulfate pentahydrate
T0792
Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate
Target: Sodium Channel
Capsaicin
T1062
Synonym: Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,Vanilloid,(E)-Capsaicin,Zostrix
Target: Apoptosis, TRP/TRPV Channel, Autophagy
Berbamine
T3S0807
Synonym:
Target: CaMK, NF-κB, Autophagy
Kaurenoic acid
T3929
Synonym: Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid
Target: Others
Vincristine
T3S0209
Synonym:
Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR
Dihydrocapsaicin
T2163
Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide
Target: Others, TRP/TRPV Channel
Methyl 3,4,5-trimethoxycinnamate
TMA0763
Synonym:
Target: Potassium Channel, Calcium Channel
Sparteine sulfate
T3029
Synonym: Depasan,Tocosimplex,Actospar
Target: Others, Sodium Channel

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-02073 Selenoprotein M/SELM Protein, Human, Recombinant Human E. coli
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
TMPH-02612 CXCR3 Protein, Mouse, Recombinant (His & KSI) Mouse E. coli
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled recep...
TMPH-02098 PPP1CB Protein, Human, Recombinant (His) Human E. coli
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
TMPY-03615 CSEN Protein, Human, Recombinant (His) Human E. coli
KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to th...
TMPJ-00888 ANXA7 Protein, Human, Recombinant Human E. coli
Annexin A7 (ANXA7) is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region. The C-terminal reg...
TMPH-00717 Protease 7 Protein, E. coli, Recombinant (His) E. coli E. coli
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm...
TMPH-03057 Chorismate synthase Protein, Neurospora crassa, Recombinant (His) Neurospora crassa E. coli
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys...
TMPY-03438 Calsequestrin 1 Protein, Human, Recombinant Human E. coli
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction,...
TMPH-01695 MLKL Protein, Human, Recombinant (His) Human Yeast
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel...
TMPJ-00666 CLIC2 Protein, Human, Recombinant (His) Human E. coli
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane in...
TMPY-02955 CABP5 Protein, Human, Recombinant (His) Human E. coli
CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. ...
TMPH-03025 VlpE Protein, Mycoplasma hyorhinis, Recombinant (His & Myc) Mycoplasma hyorhinis E. coli
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradatio...
TMPH-00933 ADTRP Protein, Human, Recombinant (His & Myc) Human in vitro E. coli expression system
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C...
TMPJ-01074 PKCE Protein, Human, Recombinant (His) Human E. coli
Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma...
TMPY-04563 CASK Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPY-01605 STIM1 Protein, Human, Recombinant (His) Human HEK293
Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human ...
TMPY-04754 CASK Protein, Human, Recombinant Human Baculovirus-Insect Cells
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPH-03753 MYLK Protein, Human, Recombinant (His) Human E. coli
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...
Selenoprotein M/SELM Protein, Human, Recombinant
TMPH-02073
Species: Human
Expression System: E. coli
CXCR3 Protein, Mouse, Recombinant (His & KSI)
TMPH-02612
Species: Mouse
Expression System: E. coli
PPP1CB Protein, Human, Recombinant (His)
TMPH-02098
Species: Human
Expression System: E. coli
CSEN Protein, Human, Recombinant (His)
TMPY-03615
Species: Human
Expression System: E. coli
ANXA7 Protein, Human, Recombinant
TMPJ-00888
Species: Human
Expression System: E. coli
Protease 7 Protein, E. coli, Recombinant (His)
TMPH-00717
Species: E. coli
Expression System: E. coli
Chorismate synthase Protein, Neurospora crassa, Recombinant (His)
TMPH-03057
Species: Neurospora crassa
Expression System: E. coli
Calsequestrin 1 Protein, Human, Recombinant
TMPY-03438
Species: Human
Expression System: E. coli
MLKL Protein, Human, Recombinant (His)
TMPH-01695
Species: Human
Expression System: Yeast
CLIC2 Protein, Human, Recombinant (His)
TMPJ-00666
Species: Human
Expression System: E. coli
CABP5 Protein, Human, Recombinant (His)
TMPY-02955
Species: Human
Expression System: E. coli
VlpE Protein, Mycoplasma hyorhinis, Recombinant (His & Myc)
TMPH-03025
Species: Mycoplasma hyorhinis
Expression System: E. coli
ADTRP Protein, Human, Recombinant (His & Myc)
TMPH-00933
Species: Human
Expression System: in vitro E. coli expression system
PKCE Protein, Human, Recombinant (His)
TMPJ-01074
Species: Human
Expression System: E. coli
CASK Protein, Human, Recombinant (His & GST)
TMPY-04563
Species: Human
Expression System: Baculovirus-Insect Cells
STIM1 Protein, Human, Recombinant (His)
TMPY-01605
Species: Human
Expression System: HEK293
CASK Protein, Human, Recombinant
TMPY-04754
Species: Human
Expression System: Baculovirus-Insect Cells
MYLK Protein, Human, Recombinant (His)
TMPH-03753
Species: Human
Expression System: E. coli
Cat No. Product Name
L7200 Calcium Channel Compound Library

143 compounds
A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening;
TargetMol