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Cat No. | Product Name | Synonyms | Targets |
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T77710 | Calcium Channel antagonist 2 | WAY-327363 | Calcium Channel |
Calcium Channel antagonist 2 is a calcium channel antagonist (IC50=5-20 μM) that can be used to study diseases due to Ca2+ channels like pain and diabetes. | |||
T10101 | Calcium channel-modulator-1 | Others , Calcium Channel | |
Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction. | |||
T77711 | Calcium Channel antagonist 4 | Calcium Channel | |
Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM). | |||
T77712 | Calcium Channel antagonist 3 | Calcium Channel | |
Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM). | |||
T12153 | N-type calcium channel blocker-1 | Calcium Channel | |
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels. | |||
T2519 | Lercanidipine | Masnidipine | Calcium Channel |
Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class. | |||
T10659 | Ca2+ channel agonist 1 | Calcium Channel , CDK | |
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction. | |||
T8944 | TTA-A2 | Calcium Channel | |
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ... | |||
T12015 | Methyl homoveratrate | Others | |
Methyl homoveratrate, a metabolite of McN5691 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker. | |||
T7603 | Pinaverium bromide | Calcium Channel | |
Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort. | |||
T1530 | Mitiglinide calcium hydrate | KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate | Potassium Channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ... | |||
T11353 | Gallopamil | Methoxyverapamil | Calcium Channel |
Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy der... | |||
T0283 | Trimethadione | 3,5,5,-Trimethyloxazolidine-2,4-dione | Calcium Channel |
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity. | |||
T8863 | VK-II-36 | Others | |
VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor. | |||
T15423 | GSK-7975A | Calcium Channel | |
GSK-7975A is a potent and orally available inhibitor of CRAC channel. | |||
T0119 | Nitrendipine | BAY-E-5009,Bayotensin | Calcium Channel , Autophagy |
Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtr... | |||
T0957 | Isradipine | PN 200-110 | Calcium Channel , Autophagy |
Isradipine (PN 200-110) is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calcium ion channels of coronary and peripheral vasc... | |||
T11353L | Gallopamil hydrochloride | Methoxyverapamil hydrochloride | Calcium Channel |
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies. | |||
T23280 | Ruthenium Red | Ammoniated ruthenium oxychloride | Calcium Channel |
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ... | |||
T10690 | Cav 2.2 blocker 1 | Calcium Channel | |
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain. | |||
T6874 | Lercanidipine hydrochloride | Corifeo,Carmen,Cardiovasc | Calcium Channel |
Lercanidipine hydrochloride (Corifeo) is a calcium channel blocker of the dihydropyridine class. | |||
T5023 | Propiverine hydrochloride | Others , Calcium Channel , AChR | |
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). | |||
T64203 | T-Type calcium channel inhibitor 2 | ||
T-Type calcium channel inhibitor 2 (compound 6g) is a potent inhibitor of the T-type calcium channel, acting on Cav3.1 (α1G) (IC50: 31.0 μM), Cav3.2 (α1H) (IC50: 83.1 μM), Cav3.3 (α1I) (α1H) ( T-Type calcium channel inhi... | |||
T8674 | SR33805 | Calcium Channel | |
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively) | |||
T13047 | Synta66 | Calcium Channel | |
Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease. | |||
T11517 | GV-58 | Calcium Channel | |
GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity. | |||
T7373 | CDN1163 | Calcium Channel | |
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). | |||
T12608 | QX-314 chloride | Sodium Channel | |
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel. | |||
T3543 | NS-638 | NS 638 | Calcium Channel |
NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM). | |||
T3703 | ABT-639 | ABT 639 | Calcium Channel |
ABT-639 is a potent and selective T-type calcium channel blocker. | |||
T0030 | Bupivacaine hydrochloride | Vivacaine,Bupivacaine HCl | Sodium Channel |
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol... | |||
T0343 | Nimodipine | BAY-e 9736 | Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy |
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells. | |||
T16014 | Mavatrep | JNJ-39439335 | TRP/TRPV Channel |
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. | |||
T22788 | FPL64176 | FPL 64176 | Calcium Channel |
FPL64176 is a L-type calcium channels activator. | |||
T0916 | Butamben | Butyl 4-aminobenzoate | Potassium Channel , Calcium Channel , Sodium Channel |
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain. | |||
T1198 | Tetracaine hydrochloride | Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl | Calcium Channel , Sodium Channel |
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use... | |||
T7216 | Mirogabalin | DS5565 | Calcium Channel |
Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects. | |||
T1510 | Rosuvastatin calcium | ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium | Potassium Channel , HMG-CoA Reductase , Autophagy |
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. | |||
T0388 | Cilnidipine | FRC-8653 | Calcium Channel |
Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. | |||
T6848 | GSK1016790A | GSK101 | Calcium Channel , TRP/TRPV Channel |
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells. | |||
T29201 | Z944 | Z 944,Z-944 | Calcium Channel |
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. | |||
T5632 | Suvecaltamide | MK-8998 | Calcium Channel |
Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels. | |||
T0702 | Gabapentin | Neurontin,Gabapentine,Aclonium | Calcium Channel , GABA Receptor |
Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T0858 | Flufenamic acid | Arlef,Nichisedan,Achless | Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite |
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. | |||
T6577 | Manidipine | Iperten,Franidipine,Artedil | Calcium Channel |
Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized | |||
T0327 | Fendiline hydrochloride | Fendiline HCl | Calcium Channel |
Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel. | |||
T10885 | CRAC intermediate 2 | Others , Calcium Channel | |
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis. | |||
T5376 | Aranidipine | MPC1304 | Calcium Channel |
Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects. | |||
T8815 | Azumolene | EU4093 free base | Calcium Channel |
Azumolene (EU4093 free base) | |||
T0903 | Cinnarizine | Stugeron,Cinarizine,Dimitronal,Stutgin | Calcium Channel , Histamine Receptor |
Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8206 | Cycleanine | Others | |
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. | |||
TN2322 | Yangambin | Calcium Channel , PAFR | |
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti... | |||
T11665 | Ionomycin calcium | SQ23377 calcium | Apoptosis , Calcium Channel , Antibacterial , Antibiotic , PKC |
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly spec... | |||
T6S1418 | Praeruptorin C | Antioxidant , Calcium Channel | |
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... | |||
T8787 | Drotaverine hydrochloride | PDE | |
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... | |||
T0728 | Ethosuximide | Zarontin | Calcium Channel |
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. | |||
T3904 | Gomisin J | Calcium Channel , AMPK | |
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK... | |||
TN1008 | Psoralenoside | CaMK , Calcium Channel , Histamine Receptor | |
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. | |||
T5723 | Menthol | DL-Menthol | Others , Calcium Channel |
Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. | |||
T15027 | Cyclopiazonic acid | Calcium Channel | |
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... | |||
T4S1422 | Praeruptorin E | Others , Calcium Channel | |
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent. | |||
T3013 | Catharanthine tartrate | Catharanthine hemitartrate | Others , Calcium Channel |
Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities. | |||
T2782 | Catharanthine | (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine | Calcium Channel , AChR |
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). | |||
T6S1500 | Ginsenoside Rf | Ginsenoside-Rf,Panaxoside Rf | Calcium Channel , Endogenous Metabolite |
Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. | |||
T4590 | (+)-Kavain | Kavain,L-KAWAIN,(R)-KAWAIN | Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter |
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. | |||
T10024 | 1-Octanol | Octanol | Calcium Channel , Endogenous Metabolite |
1-Octanol (Octanol) (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like prope... | |||
T4727 | Taurolithocholic acid sodium salt | Sodium taurolithocholate | Others , Calcium Channel |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. | |||
TN7108 | Urolithin C | Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite | |
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. | |||
T4S1419 | (±)-Praeruptorin A | Praeruptorin A,(-)-Praeruptorin A | p38 MAPK , Calcium Channel , Akt |
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... | |||
T3S1916 | Heteroclitin D | Calcium Channel | |
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor. | |||
T5701 | OPHIOPOGONIN D | RAAS , Calcium Channel , NF-κB , PPAR | |
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. | |||
T2996 | Tetrandrine | NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A | Potassium Channel , Calcium Channel |
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T1221 | Acetylcholine chloride | ACh chloride,Pilofrin | Calcium Channel , Endogenous Metabolite , AChR |
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... | |||
T8288 | 14-Deoxyandrographolide | Apoptosis , Others | |
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T5S2059 | Glaucine | Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE | |
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... | |||
T0928 | L-Ascorbic acid | Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate | Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite |
L-Ascorbic acid (Vitamin C) is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. | |||
T3915 | Ginsenoside Ro | Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V | Calcium Channel , Reductase , Prostaglandin Receptor |
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. | |||
T2878 | Ginsenoside Rd | Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII | P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite |
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. | |||
T3377 | L-Phenylalanine | (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine | Calcium Channel , Endogenous Metabolite , iGluR |
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels. | |||
T2946 | Tanshinone IIA sulfonate sodium | Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium | CaMK , P450 , Calcium Channel |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... | |||
T6674 | L-Ascorbic acid sodium salt | (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate | Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite |
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T23735 | Jamaicin | An-Co-A4,AnCoA-4,An Co A4,AnCoA4 | Calcium Channel |
Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation. | |||
T0792 | (-)-Sparteine sulfate pentahydrate | (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate | Sodium Channel |
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. | |||
T1062 | Capsaicin | Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,Vanilloid,(E)-Capsaicin,Zostrix | Apoptosis , TRP/TRPV Channel , Autophagy |
Capsaicin ((E)-Capsaicin) is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This is why capsaicin is linked... | |||
T3S0807 | Berbamine | CaMK , NF-κB , Autophagy | |
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects. | |||
T3929 | Kaurenoic acid | Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid | Others |
Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,... | |||
T3S0209 | Vincristine | ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR | |
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato... | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
TMA0763 | Methyl 3,4,5-trimethoxycinnamate | Potassium Channel , Calcium Channel | |
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel. | |||
T3029 | Sparteine sulfate | Depasan,Tocosimplex,Actospar | Others , Sodium Channel |
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02073 | Selenoprotein M/SELM Protein, Human, Recombinant | Human | E. coli |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. | |||
TMPH-02612 | CXCR3 Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled recep... | |||
TMPH-02098 | PPP1CB Protein, Human, Recombinant (His) | Human | E. coli |
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. | |||
TMPY-03615 | CSEN Protein, Human, Recombinant (His) | Human | E. coli |
KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to th... | |||
TMPJ-00888 | ANXA7 Protein, Human, Recombinant | Human | E. coli |
Annexin A7 (ANXA7) is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region. The C-terminal reg... | |||
TMPH-00717 | Protease 7 Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm... | |||
TMPH-03057 | Chorismate synthase Protein, Neurospora crassa, Recombinant (His) | Neurospora crassa | E. coli |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys... | |||
TMPY-03438 | Calsequestrin 1 Protein, Human, Recombinant | Human | E. coli |
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction,... | |||
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel... | |||
TMPJ-00666 | CLIC2 Protein, Human, Recombinant (His) | Human | E. coli |
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane in... | |||
TMPY-02955 | CABP5 Protein, Human, Recombinant (His) | Human | E. coli |
CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. ... | |||
TMPH-03025 | VlpE Protein, Mycoplasma hyorhinis, Recombinant (His & Myc) | Mycoplasma hyorhinis | E. coli |
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradatio... | |||
TMPH-00933 | ADTRP Protein, Human, Recombinant (His & Myc) | Human | in vitro E. coli expression system |
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C... | |||
TMPJ-01074 | PKCE Protein, Human, Recombinant (His) | Human | E. coli |
Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma... | |||
TMPY-04563 | CASK Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2... | |||
TMPY-01605 | STIM1 Protein, Human, Recombinant (His) | Human | HEK293 |
Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human ... | |||
TMPY-04754 | CASK Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2... | |||
TMPH-03753 | MYLK Protein, Human, Recombinant (His) | Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos... |
Cat No. | Product Name | ||
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L7200 | Calcium Channel Compound Library | 143 compounds | |
A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; |