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GPCR/G Protein Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Cat No. product name
T10510 CB1 antagonist 1 CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gas...
T10694 CB1 inverse agonist 1 CB1 inverse agonist 1 is an orally active, and specific inverse agonist of the CB1 receptor (IC50s: 7.5 nM and 4100 nM for CB1 and CB2 receptors) with anorexige...
T13081 Taranabant racemate Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
T14204 6-Iodopravadoline 6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
T14302 Olorinab Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
T14504 BAY 38-7271 BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM a...
T1519 Rimonabant hydrochloride Rimonabant hydrochloride is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
T1519L Rimonabant Rimonabant is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue...
T16928 SR144528 SR144528 is an effective and selective antagonist of the CB2 receptor (Ki: 0.6 nM).
T17027 Tedalinab Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab...
T1796 Otenabant hydrochloride Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
T1915 AM251 AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39...
T2264 AM281 AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T2635 Org 27569 Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and ...
T3530 Otenabant Otenabant has been investigated for the treatment of Obesity.
T3699 Bay 59-3074 Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic...
T3S0738 yangonin 1. Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the i...
T4453 JD5037 JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
T4458 WIN 55,212-2 Mesylate WIN 55, 212-2 (Mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors,...
T4654 SLV319 SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
T5996 CB1-IN-1 CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T6417 BML190 BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
T6527 GW842166X GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase...
T6755 AM1241 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T7316 LY2828360 LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM...
T7375 A-836339 A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 rece...
T7705 GW 405833 GW 405833 is an agonist of cannabinoid-2 (CB(2)) receptor-selective
T8511 TM38837 TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
T9114 β-Caryophyllene β-Caryophyllene is a CB2 receptor agonist.
TN2268 Tetrahydromagnolol Tetrahydromagnolol can activate cannabinoid (CB) receptors.
TN5131 Tetrahydrocannabivarin Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, t...
TQ0173 MDA 19 MDA 19 is a specific human CB2 receptor agonist (Ki: 43.3 nM).
TWS0414 Cannabidiol Cannabidiol is GPR55 and weak CB1 antagonist (IC50s: 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50: 27.5 μM). It a...
CB1 antagonist 1
T10510CAS 890037-68-0
CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gas...
CB1 inverse agonist 1
T10694CAS 852315-00-5
CB1 inverse agonist 1 is an orally active, and specific inverse agonist of the CB1 receptor (IC50s: 7.5 nM and 4100 nM for CB1 and CB2 receptors) with anorexige...
Taranabant racemate
T13081CAS 701977-00-6
Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
6-Iodopravadoline
T14204CAS 164178-33-0
6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
Olorinab
T14302CAS 1268881-20-4
Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
BAY 38-7271
T14504CAS 212188-60-8
BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM a...
Rimonabant hydrochloride
T1519CAS 158681-13-1
Rimonabant hydrochloride is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
Rimonabant
T1519LCAS 168273-06-1
Rimonabant is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue...
SR144528
T16928CAS 192703-06-3
SR144528 is an effective and selective antagonist of the CB2 receptor (Ki: 0.6 nM).
Tedalinab
T17027CAS 916591-01-0
Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab...
Otenabant hydrochloride
T1796CAS 686347-12-6
Otenabant hydrochloride (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
AM251
T1915CAS 183232-66-8
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39...
AM281
T2264CAS 202463-68-1
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
Org 27569
T2635CAS 868273-06-7
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and ...
Otenabant
T3530CAS 686344-29-6
Otenabant has been investigated for the treatment of Obesity.
Bay 59-3074
T3699CAS 406205-74-1
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic...
yangonin
T3S0738CAS 500-62-9
1. Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the i...
JD5037
T4453CAS 1392116-14-1
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
WIN 55,212-2 Mesylate
T4458CAS 131543-23-2
WIN 55, 212-2 (Mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors,...
SLV319
T4654CAS 362519-49-1
SLV319 has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
CB1-IN-1
T5996CAS 1429239-98-4
CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
BML190
T6417CAS 2854-32-2
BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
GW842166X
T6527CAS 666260-75-9
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase...
AM1241
T6755CAS 444912-48-5
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
LY2828360
T7316CAS 1231220-79-3
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM...
A-836339
T7375CAS 959746-77-1
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 rece...
GW 405833
T7705CAS 180002-83-9
GW 405833 is an agonist of cannabinoid-2 (CB(2)) receptor-selective
TM38837
T8511CAS 1253641-65-4
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
β-Caryophyllene
T9114CAS 87-44-5
β-Caryophyllene is a CB2 receptor agonist.
Tetrahydromagnolol
TN2268CAS 20601-85-8
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
Tetrahydrocannabivarin
TN5131CAS 31262-37-0
Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, t...
MDA 19
TQ0173CAS 1048973-47-2
MDA 19 is a specific human CB2 receptor agonist (Ki: 43.3 nM).
Cannabidiol
TWS0414CAS 13956-29-1
Cannabidiol is GPR55 and weak CB1 antagonist (IC50s: 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50: 27.5 μM). It a...