Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.

Cat No.	product name
T0106	Methazolamide	Methazolamide is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
T0114	Trichlormethiazide	Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
T0142	Brinzolamide	Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
T0267	Zonisamide	Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
T0465	Ellagic acid	Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T0515	Tioxolone	Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
T0675	Topiramate	Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
T0677	Chlorothiazide	Chlorothiazide is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.
T0738	Urea	Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
T0782	Benzthiazide	Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit...
T0813	Acetazolamide	Acetazolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification o...
T1026	Mafenide hydrochloride	Mafenide hydrochloride is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
T1204	Bendroflumethiazide	A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
T1409	Methocarbamol	Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musc...
T1449	Hydrochlorothiazide	Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T2017	U-104	U-104 is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
T2134	Dorzolamide hydrochloride	Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid c...
T2530	Levosimendan	Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calc...
T2616	PIK-93	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T6469	Dichlorphenamide	Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
T6781	Benzenesulfonamide	<p>Benzenesulfonamide ia an inhibitor of carbonic anhydrases.</p>
T4321	Indisulam	Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and...
T6S0221	Eriocitrin	1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects i...
T5012	Ethoxzolamide	Ethoxzolamide is a carbonic anhydrase inhibitor.
T4S2354	Dimethylfraxetin	Dimethylfraxetin is a Carbonic anhydrase inhibitor（Ki：0.0097 μM）
T1999	Taselisib	Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity...