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Metabolism Carbonic Anhydrase

Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Cat No. product name
T0106 Methazolamide Methazolamide is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
T0114 Trichlormethiazide Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
T0142 Brinzolamide Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T0515 Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
T0677 Chlorothiazide Chlorothiazide is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
T0782 Benzthiazide Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit...
T0813 Acetazolamide Acetazolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification o...
T1026 Mafenide hydrochloride Mafenide hydrochloride is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
T1204 Bendroflumethiazide A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
T1409 Methocarbamol Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musc...
T1449 Hydrochlorothiazide Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T2017 U-104 U-104 is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
T2134 Dorzolamide hydrochloride Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid c...
T2530 Levosimendan Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calc...
T2616 PIK-93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T6469 Dichlorphenamide Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
T6781 Benzenesulfonamide <p>Benzenesulfonamide ia an inhibitor of carbonic anhydrases.</p>
T4321 Indisulam Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and...
T6S0221 Eriocitrin 1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects i...
T5012 Ethoxzolamide Ethoxzolamide is a carbonic anhydrase inhibitor.
T4S2354 Dimethylfraxetin Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
T1999 Taselisib Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity...
Methazolamide
T0106CAS 554-57-4
Methazolamide is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Trichlormethiazide
T0114CAS 133-67-5
Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
Brinzolamide
T0142CAS 138890-62-7
Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
Zonisamide
T0267CAS 68291-97-4
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
Ellagic acid
T0465CAS 476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
Tioxolone
T0515CAS 4991-65-5
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
Topiramate
T0675CAS 97240-79-4
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
Chlorothiazide
T0677CAS 58-94-6
Chlorothiazide is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.
Urea
T0738CAS 57-13-6
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
Benzthiazide
T0782CAS 91-33-8
Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit...
Acetazolamide
T0813CAS 59-66-5
Acetazolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification o...
Mafenide hydrochloride
T1026CAS 138-37-4
Mafenide hydrochloride is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
Bendroflumethiazide
T1204CAS 73-48-3
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
Methocarbamol
T1409CAS 532-03-6
Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musc...
Hydrochlorothiazide
T1449CAS 58-93-5
Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
U-104
T2017CAS 178606-66-1
U-104 is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
Dorzolamide hydrochloride
T2134CAS 130693-82-2
Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid c...
Levosimendan
T2530CAS 141505-33-1
Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calc...
PIK-93
T2616CAS 593960-11-3
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Dichlorphenamide
T6469CAS 120-97-8
Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Benzenesulfonamide
T6781CAS 98-10-2
<p>Benzenesulfonamide ia an inhibitor of carbonic anhydrases.</p>
Indisulam
T4321CAS 165668-41-7
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and...
Eriocitrin
T6S0221CAS 13463-28-0
1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects i...
Ethoxzolamide
T5012CAS 452-35-7
Ethoxzolamide is a carbonic anhydrase inhibitor.
Dimethylfraxetin
T4S2354CAS 6035-49-0
Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
Taselisib
T1999CAS 1282512-48-4
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity...