Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.

Cat. No.	Product name	CAS No.	Purity
T9175	Casein Kinase inhibitor A51	2079068-74-7	98.42%
T9175	Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be u...
T78622	Ac-VDVAD-CHO	194022-51-0	98%
T78622	Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].
T79127	Casein kinase 1δ-IN-4	851168-98-4	98%
T79127	"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."
T79145	CK1-IN-2	1383376-92-8	98%
T79145	CK1-IN-2 (compound Nr.4) is a potent inhibitor of CK1, exhibiting IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a [1].
T79154	Casein kinase 1δ-IN-5	1579991-10-8	98%
T79154	Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in v...
T79697	Casein kinase 1δ-IN-10	332074-85-8	98%
T79697	Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ) referenced in WO2012080729A2 as compound 685 [1].
T79908	ON 108600	1585246-23-6	98%
T79908	ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.0...
T80076	Ac-ESMD-CHO	191338-87-1	98%
T80076	Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (CPP3...
T16507	PF-5006739	1293395-67-1	98%
T16507	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range o...
T10829	CKI-7 free base	120615-25-0	98%
T10829	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base...
T8305	Ellagic acid (hydrate)	314041-08-2	98%
T8305	Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
T71627	CX-5011	1009821-06-0	98%
T71627	CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].
T2440	IC261	186611-52-9	99.86%
T2440	IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T6735	XL413 hydrochloride	2062200-97-7	99.82%
T6735	XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also ex...
T2449	D4476	301836-43-1	99.8%
T2449	D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T14069	A-3 hydrochloride	78957-85-4	99.79%
T14069	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T2008	LY294002	154447-36-6	99.76%
T2008	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC...
T0465	Ellagic acid	476-66-4	99.76%
T0465	Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the ...
T9356	(E/Z)-GO289	694522-87-7	99.68%
T9356	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of canc...
T2048	LY-364947	396129-53-6	99.65%
T2048	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.