Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
TN1086	Dehydrotrametenolic acid	6879-05-6
TN1086	Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
TN3404	Altholactone	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257	Tanshinone IIB	17397-93-2	98%
TN2257	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4932	Sageone	142546-15-4	98%
TN4932	Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
T79497	M826		98%
T79497	M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro...
T79498	M867	680999-39-7	98%
T79498	M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].
T79747	M190S	2578300-07-7	98%
T79747	M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo. It shows promise...
T79992	Sarglaroids F		98%
T79992	Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+ efflu...
T80093	IETD-CHO TFA		98%
T80093	IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].
T80109	Z-VEID-AFC	219138-06-4	98%
T80109	Z-VEID-AFC is a caspase-6 fluorescent substrate [1].
T80110	Ac-VRPR-AMC	919515-51-8	98%
T80110	Ac-VRPR-AMC is a fluorogenic substrate for metacaspase activity assays, facilitating the detection and measurement of metacaspase activity [1].
T80201	Tripeptide-32	1185583-20-3	98%
T80201	Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].
T80467	Boc-AEVD-CHO	220094-15-5	98%
T80467	Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].
T80531	Ac-AAVALLPAVLLALLAP-DEVD-CHO	201608-15-3	98%
T80531	Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].
T80532	Ac-AAVALLPAVLLALLAP-YVAD-CHO	201608-12-0	98%
T80532	Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].
T80536	Ac-AAVALLPAVLLALLAP-LEVD-CHO	886462-82-4	98%
T80536	Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4 that exhibits antitumor activity [1].
T80537	Ac-AAVALLPAVLLALLAP-LEHD-CHO	623948-42-5	98%
T80537	Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated with Neocarzinostatin...
T80545	Ac-VEID-AFC		98%
T80545	Ac-VEID-AFC is a fluorogenic substrate for caspase-6, utilized in caspase-6 activity assays [1].
T80624	Ac-VAD-CHO	147837-52-3	98%
T80624	Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of cytochrome...
T80659	Z-YVAD-CMK	402474-85-5	98%
T80659	Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].