Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	1926163-65-6	98%
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that irreversibly binds to activated caspase...
T82774	Caspase-3 activator 3		98%
T82774	Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activ...
T82775	Caspase-3 activator 2		98%
T82775	Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM, re...
T83205	Ac-DNLD-CHO	775289-20-8	98%
T83205	Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7 ...
T78586L	Ac-IETD-CHO TFA		98%
T78586L	Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-medi...
T21523	β-Tocotrienol	490-23-3	98%
T21523	Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG ...
TN1642	Ferruginol	514-62-5	98%
TN1642	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
TN4496	Marginatoxin	1422536-56-8	98%
TN4496	Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in v...
TN4877	Quercetin 3,4'-dimethyl ether	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN5033	Skullcapflavone I	41060-16-6	98%
TN5033	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
TN2835	28-Deoxonimbolide	126005-94-5	98%
TN2835	28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells.
TN2977	3-O-trans-p-Coumaroyltormentic acid	121064-78-6	98%
TN2977	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in ...
T10548	Biotin-VAD-FMK	1135688-15-1	98%
T10548	Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.
T4366	Quinovic acid	465-74-7	98%
T4366	Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
T13797	Nivalenol	23282-20-4	98%
T13797	Nivalenol is a fungal metabolite produced by Fusarium graminearum. Nivalenol induces cell death through caspase and intrinsic apoptotic pathways thus affecting t...
TN3525	Boehmenan	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN2511	Britannilactone diacetate	1286694-67-4	98%
TN2511	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN3708	Coronarin D	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T14003	15-Acetoxyscirpenol	2623-22-5	98%
T14003	15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-de...
T2S0606	Bakkenolide A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...