Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
TN2002	Obovatol	83864-78-2	98%
TN2002	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...
TP2161	Z-WEHD-FMK	210345-00-9	98%
TP2161	Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
TN4160	Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN2034	Paeoniflorigenone	80454-42-8	98%
TN2034	Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
TN2691	2',3'-Dehydrosalannol	97411-50-2	98%
TN2691	2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
TN1532	Crenulatin	63026-02-8	98%
TN1532	Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L ...
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T16998	Tauroursodeoxycholate dihydrate	117609-50-4	98%
T16998	Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
TN3922	Effusanin E	76470-15-0	98%
TN3922	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN4944	Santamarine	4290-13-5	98%
TN4944	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidin...
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	57719-81-0	98%
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN1837	Kuguaglycoside C	1041631-93-9	98%
TN1837	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
TN2040	Panaxynol	81203-57-8	98%
TN2040	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN4046	Excisanin A	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TMA0918	Neochamaejasmine A	90411-13-5	98%
TMA0918	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it ...
TN4307	Isolimonexic acid	73904-93-5	98%
TN4307	Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
T5526	Glycoborinine	233279-39-5	98%
T5526	Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
TN1538	Curzerenone	20493-56-5	98%
TN1538	Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
T11210	EP1013	223568-55-6	98%
T11210	EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
TN4271	Isochamaejasmine	93859-63-3	98%
TN4271	Isochamaejasmine, isolated from S. chamaejasme L., inhibits NF-κB activation. Isochamaejasmine induces leukemia cell apoptosis by inhibiting the activity of Bcl-...