Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
T2S2362	Dehydrocorydaline nitrate	13005-09-9	99.79%
T2S2362	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
T6993	Tauroursodeoxycholate sodium	35807-85-3	99.78%
T6993	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T2503	PAC-1	315183-21-2	99.77%
T2503	PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers,...
T3384	Wedelolactone	524-12-9	99.76%
T3384	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
TN2329	Zingiberen newsaponin	91653-50-8	99.75%
TN2329	Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
T21871	MMPSI	220509-74-0	99.74%
T21871	MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or...
T5S2076	Senkyunolide I	94596-28-8	99.73%
T5S2076	1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.
TN1153	Polyporenic acid C	465-18-9	99.71%
TN1153	Polyporenic acid C shows inhibitory activity against human collagenase.
T3914	Saikosaponin C	20736-08-7	99.71%
T3914	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T6005	Z-DEVD-FMK	210344-95-9	99.69%
T6005	Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspa...
T2A2481	Taurochenodeoxycholic Acid	516-35-8	99.69%
T2A2481	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
TN1601	Effusol	73166-28-6	99.67%
TN1601	Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1...
T2959	Ginsenoside Rh2	78214-33-2	99.65%
T2959	Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.
T9113	Myristicin	607-91-0	99.63%
T9113	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
T3S1227	Aristolactam I	13395-02-3	99.63%
T3S1227	1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristolo...
T7016	VR23	1624602-30-7	99.62%
T7016	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for ca...
T4S0498	Glaucocalyxin A	79498-31-0	99.56%
T4S0498	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase...
T6090	Belnacasan	273404-37-8	99.5%
T6090	Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.
T7727	Se-Methylselenocysteine	26046-90-2	99.49%
T7727	Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
T15035	Cystamine	51-85-4	99.41%
T15035	Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in stu...