Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
T9713	δ-secretase inhibitor 11	842964-18-5	99.4%
T9713	δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
T1266	Terfenadine	50679-08-8	99.36%
T1266	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
TN1891	Lupiwighteone	104691-86-3	99.20%
TN1891	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T6826	Emricasan	254750-02-2	99.11%
T6826	Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties. Emricasan has anti-inflammatory and anti-apoptotic activity and can be used in the ...
T4241	Rubiadin	117-02-2	99.1%
T4241	Rubiadin (1,3-Dihydroxy-2-Methylanthracene-9,10-Dione) possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydro...
T75319	Taurodeoxycholic acid	516-50-7	99.09%
T75319	Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes an...
T70038	MJN68390	1956368-39-0	99.06%
T70038	MJN68390 has an apparent IC50 value of 15 μM against CASP8 and shows no activity against CASP10.
T5S2283	Sesamolin	526-07-8	98.89%
T5S2283	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
TJA2398	Taurodeoxycholic acid sodium hydrate	110026-03-4	98.87%
TJA2398	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
TN1675	Gardenin B	2798-20-1	98.71%
TN1675	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T9118	KEA1-97	2138882-71-8	98.7%
T9118	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspa...
TQ0146	Ac-DEVD-CHO	169332-60-9	98.69%
TQ0146	Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.
T1772	MDK83190	79183-19-0	98.67%
T1772	MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T7020	Z-VAD-FMK	161401-82-7	98.63%
T7020	Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases with irreversible properties. Z-VAD-FMK binds to activated caspases, thereby inhibitin...
T21936	M50054	54135-60-3	98.62%
T21936	Apoptosis Inhibitor was a novel inhibitor of programmed cell death associate with caspase-3 inhibition.
T77579	JC2-11	937820-89-8	98.6%
T77579	JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
TQ0146L	Ac-DEVD-CHO acetate	TQ0146L	98.54%
TQ0146L	Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.
T27242	EF24	342808-40-6	98.47%
T27242	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of M...
T5S2358	Dehydrocorydaline	30045-16-0	98.36%
T5S2358	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
T0859	Fenbufen	36330-85-5	98.35%
T0859	Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It ...