Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product name	CAS No.	Purity
T26193	SKLB-163	1255099-06-9	98.31%
T26193	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
T2698	Asperosaponin VI	39524-08-8	98.28%
T2698	Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumat...
T18909	Ac-DEVD-AMC	169332-61-0	98.20%
T18909	Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .
T73556	CZL55	667408-87-9	98.19%
T73556	CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).
T11696	Ivachtin	745046-84-8	98.17%
T11696	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining cas...
T2532	Tauroursodeoxycholate	14605-22-2	98.12%
T2532	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. T...
T3S0335	Soyasaponin Bb	51330-27-9	98.11%
T3S0335	1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiti...
T9083	TC11	100823-03-8	98.1%
T9083	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis vi...
T2122	Ixazomib	1072833-77-2	98.07%
T2122	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S pro...
T16522	Phenoxodiol	81267-65-4	98.07%
T16522	Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expre...
T3600	Licochalcone A	58749-22-7	98.02%
T3600	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
TP1466	Z-YVAD-FMK	210344-97-1	98.00%
TP1466	AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.
TN1650	Friedelin	559-74-0	98%
TN1650	Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
T5558	Chelidonic acid	99-32-1	98%
T5558	Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidoni...
T5574	Guggulsterone	95975-55-6	98%
T5574	Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5S1632	Barlerin	57420-46-9	98%
T5S1632	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
T6761	Ossirene	106566-58-9	98%
T6761	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
T5S1805	5,7-Dihydroxychromone	31721-94-5	98%
T5S1805	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
T5S2083	Puerarin 6''-O-Xyloside	114240-18-5	98%
T5S2083	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are relate...
T30077	Anisperimus	170368-04-4	97.81%
T30077	Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level...