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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones Enzyme GPCR/G Protein Immunology / Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology&virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Fragment Libraries Diversity Sets Custom Compound Library
Signaling pathway Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones Enzyme GPCR/G Protein Immunology / Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology&virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling
Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused
Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Diversity Sets Golden Scaffold Library Mini Scaffold Library
Fragment Libraries Drug-fragment Library Featured Fragment Library High Solubility Fragment Library Custom Compound Library
Membrane transporter/Ion channel Chloride channel

Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.
Cat No. product name
T0019 Betaine hydrochloride Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing th...
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T1125 (+)-Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pa...
T4330 CaCCinh-A01 CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T4503 Talniflumate Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
T4811 D-Alanine Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and ...
T5225 Hypotaurine Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
T7638 NPPB NPPB is a chloride channel blocker with IC50 of 80 nM .
T8039 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
Betaine hydrochloride
T0019CAS 590-46-5
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing th...
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
(+)-Shikonin
T1125CAS 517-89-5
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pa...
CaCCinh-A01
T4330CAS 407587-33-1
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Talniflumate
T4503CAS 66898-62-2
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
D-Alanine
T4811CAS 338-69-2
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and ...
Hypotaurine
T5225CAS 300-84-5
Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
NPPB
T7638CAS 107254-86-4
NPPB is a chloride channel blocker with IC50 of 80 nM .
Brucine sulfate heptahydrate
T8039CAS 60583-39-3
Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
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