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Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16535 Picrotoxinin 17617-45-7 98.07%
Picrotoxinin
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant p...
T7638 NPPB 107254-86-4 98%
NPPB
NPPB is a chloride channel blocker with IC50 of 80 nM .
T0019 Betaine chloride 590-46-5 98%
Betaine chloride
Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DN...
T13059 T16Ainh-A01 552309-42-9 98%
T16Ainh-A01
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated ...
T16533 Picrotin 21416-53-5 97.11%
Picrotin
Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.
T15192 Eact 461000-66-8
Eact
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
T5225 Hypotaurine 300-84-5
Hypotaurine
Hypotaurine (2-Aminoethanesulfinic acid), functioning as an intermediate in the biosynthesis of taurine from cysteine within astrocytes, acts as an endogenous in...
T50082 Org 25543 363628-88-0
Org 25543
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
T4811 D-Alanine 338-69-2 98%
D-Alanine
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
T0275 Meticrane 1084-65-7 98%
Meticrane
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
T4059 Selamectin 220119-17-5 98%
Selamectin
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in ...
Picrotoxinin
T16535
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant p...
NPPB
T7638
NPPB is a chloride channel blocker with IC50 of 80 nM .
Betaine chloride
T0019
Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DN...
T16Ainh-A01
T13059
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated ...
Picrotin
T16533
Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.
Eact
T15192
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
Hypotaurine
T5225
Hypotaurine (2-Aminoethanesulfinic acid), functioning as an intermediate in the biosynthesis of taurine from cysteine within astrocytes, acts as an endogenous in...
Org 25543
T50082
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
D-Alanine
T4811
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
Meticrane
T0275
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
Selamectin
T4059
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in ...
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TargetMol