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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38332 | Complement factor D-IN-2 | Complement System | |
Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D. | |||
TP1304 | Compstatin | Complement System | |
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor. | |||
T9915 | Eculizumab | Complement System | |
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5 | |||
T8509 | Danicopan | ACH-4471 | Complement System |
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ... | |||
T12851 | SB290157 trifluoroacetate | Complement System | |
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM). | |||
T9189 | Iptacopan hydrochloride | Iptacopan HCl,LNP023 hydrochloride | Complement System |
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b... | |||
T3638 | Leukadherin-1 | Integrin , Complement System | |
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation. | |||
T9316 | JR14a | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride | Complement System |
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. | |||
T17250 | W-54011 | ROS , Complement System | |
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g... | |||
T7776 | ADH-503 | GB1275 | Complement System |
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. | |||
T1076 | Dexamethasone | MK 125,Prednisolone F,NSC 34521,Hexadecadrol | Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System |
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced... | |||
T7497 | C3a (70-77) | Complement 3a (70-77),C3a 70-77 | Complement System |
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a. | |||
T13379 | (Z)-Leukadherin-1 | ADH-503 free base | Complement System |
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. | |||
T38287 | C3a Receptor Agonist | C3a receptor agonist 1,Complement 3a Receptor Agonist | Complement System |
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin... | |||
T38951 | Isatuximab | SAR-650984,hu38SB19,Isatuximab-irfc | Apoptosis , CD38 |
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ... | |||
T11269 | FD-IN-1 | Others | |
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a... | |||
T75775 | Compstatin TFA | ||
Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i... | |||
TP1866 | β-Amyloid (1-11) | β-amyloid 1-11 | |
Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients. | |||
T77219 | N-((Allyloxy)carbonyl)-N-methyl-L-alanine | ||
N-((Allyloxy)carbonyl)-N-methyl-L-alanine, an alanine derivative, serves as a precursor for the synthesis of complement factor D inhibitors, which are key in researching immune system-related diseases [1]. | |||
T77089 | Mirococept | ||
Mirococept (APT070), an antibody designed to target the complement system components C3b/C4b and act as a membrane-localizing C3 convertase inhibitor, effectively diminishes the release of C-peptide and pro-inflammatory ... | |||
T64692 | AMY-101 acetate | ||
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0945 | Cyclosporin A | Cyclosporine A,Ciclosporin,Cyclosporine | Phosphatase , Antibiotic , Complement System |
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM). | |||
T40646 | Lipoteichoic acid | Complement System | |
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway. | |||
TN3430 | Apigenin 4'-O-rhamnoside | Others | |
Apigenin-4'-O-rhamnosylglucoside can strongly inhibit the classical pathway of the complement system. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00686 | Complement C2 Protein, Human, Recombinant (His) | Human | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPY-03565 | Mannan Binding Lectin/MBL2 Protein, Human, Recombinant | Human | CHO |
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ... | |||
TMPY-02268 | CD93/C1qR1 Protein, Human, Recombinant (His) | Human | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-06844 | CD93/C1qR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-06027 | CD93/C1qR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-03763 | Neuropilin-2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac... | |||
TMPY-00892 | Neuropilin-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac... | |||
TMPK-01023 | Complement factor I Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. | |||
TMPK-00776 | Complement factor I Protein, Human, Recombinant (His) | Human | HEK293 |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. | |||
TMPH-02607 | Complement factor B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert... | |||
TMPJ-00809 | CFH Protein, Human, Recombinant (His) | Human | Human Cells |
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal ... | |||
TMPH-02602 | C1RA Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. | |||
TMPY-02023 | CD46 Protein, Human, Recombinant (His) | Human | HEK293 |
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white bloo... | |||
TMPH-02603 | C1SB Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | |||
TMPH-02376 | OmpC Protein, Klebsiella pneumoniae, Recombinant (His & Myc) | Klebsiella pneumoniae | E. coli |
Forms pores that allow passive diffusion of small molecules across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system. | |||
TMPY-02167 | Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) | Mouse | HEK293 |
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ... | |||
TMPY-03012 | Complement C7 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and... | |||
TMPY-02892 | Complement C7 Protein, Human, Recombinant (His) | Human | HEK293 |
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and... | |||
TMPY-02183 | Complement Factor D/CFD Protein, Human, Recombinant (His) | Human | HEK293 |
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ... | |||
TMPY-06585 | C1s Protein, Human, Recombinant (His) | Human | HEK293 |
Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex comp... | |||
TMPH-02597 | C1QA Protein, Mouse, Recombinant (His) | Mouse | Yeast |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and effi... | |||
TMPJ-01064 | Serpin G1 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement sy... | |||
TMPY-06679 | CD55/DAF Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-00713 | CD55/DAF Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-04129 | Complement factor H/CFH Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens... | |||
TMPJ-00502 | Serpin G1 Protein, Human, Recombinant (His) | Human | Human Cells |
As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein... | |||
TMPH-02596 | C1QA Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and effi... | |||
TMPH-02655 | Ficolin 1/FCN1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of ... | |||
TMPY-00687 | Complement C2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPY-01292 | CD55/DAF Protein, Human, Recombinant (His) | Human | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-04141 | Complement factor H/CFH Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens... | |||
TMPY-02616 | CD55/DAF Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-03004 | CD55/DAF Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPH-00231 | Complement C3 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,... | |||
TMPY-03447 | Complement C2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPH-02604 | Complement C3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,... | |||
TMPY-01712 | C1QB Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulon... | |||
TMPY-04322 | Mannan Binding Lectin/MBL2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ... | |||
TMPY-00429 | Mannan Binding Lectin/MBL2 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 |
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ... | |||
TMPY-03473 | MBL1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Mannose-binding lectin (MBL), also named mannose or mannan-binding protein (MBP), is a C-type lectin that participates in the innate immune system as an activator of the complement system and as opsonin after binding to ... | |||
TMPY-00993 | MBL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Mannose-binding lectin (MBL), also named mannose or mannan-binding protein (MBP), is a C-type lectin that participates in the innate immune system as an activator of the complement system and as opsonin after binding to ... | |||
TMPY-02565 | MOG Protein, Mouse, Recombinant (aa 30-149, His) | Mouse | E. coli |
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only i... | |||
TMPY-01733 | SIGNR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-00994 | MOG Protein, Human, Recombinant (aa 30-149, His) | Human | E. coli |
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only i... | |||
TMPY-02262 | CD93/C1qR1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-06704 | CD93/C1qR1 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-00306 | CD93/C1qR1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-01692 | NETO1 Protein, Human, Recombinant (His) | Human | HEK293 |
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR... | |||
TMPY-04812 | Neuropilin-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac... |