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Proteases/Proteasome Cysteine Protease

Cysteine Protease

Cat No. product name
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0789 PMSF Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
T1080 2-Aminoethanethiol Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
T1850 Balicatib Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
T2470 Calpain Inhibitor III Calpain Inhibitor III is a Cysteine protease.
T2493 PD 151746 PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
T3088 N-Ethylmaleimide N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T3420 CA-074 methyl ester CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
T6035 Odanacatib Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
T6037 E-64 E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T6040 Aloxistatin Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibit...
T6432 Calpeptin Calpeptin is a potent, cell-permeable calpain inhibitor.
T6564 Leupeptin Hemisulfate Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
T6573 Loxistatin Acid Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
T6738 Z-FA-FMK Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T6925 P005091 P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
T4403 AX-024 HCl AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), inter...
T5211 NSC185058 NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T7451 2-cyano-Pyrimidine 2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
TQ0116 LY 3000328 LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
T12051 MIV-247 MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
T10924 Cysteine protease inhibitor-2 Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT11...
T12819 S130 S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
T12909 SID 26681509 SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
T13705 GLPG2451 GLPG2451  effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.GLPG2451 is a cystic fibrosis transmembrane conductance regulat...
T11554 Cathepsin Inhibitor 2 Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor ,has a Ki of <20 nM. 
T15641 K777 K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is a...
T13439 (RS)-Butyryltimolol (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is a β-adrenergic blocker.
T16104 ML-9 hydrochloride ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibi...
T16106 ML224 ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
T16394 ONO-5334 ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334...
T16474 Petesicatib Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T11846 LHVS LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine prot...
T11896 LV-320 LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 is a potent and uncompetitive AT...
Dexibuprofen
T0448CAS 51146-56-6
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
PMSF
T0789CAS 329-98-6
Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
2-Aminoethanethiol
T1080CAS 60-23-1
Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
Balicatib
T1850CAS 354813-19-7
Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
Calpain Inhibitor III
T2470CAS 88191-84-8
Calpain Inhibitor III is a Cysteine protease.
PD 151746
T2493CAS 179461-52-0
PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
N-Ethylmaleimide
T3088CAS 128-53-0
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
CA-074 methyl ester
T3420CAS 147859-80-1
CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
Odanacatib
T6035CAS 603139-19-1
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
E-64
T6037CAS 66701-25-5
E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
Aloxistatin
T6040CAS 88321-09-9
Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibit...
Calpeptin
T6432CAS 117591-20-5
Calpeptin is a potent, cell-permeable calpain inhibitor.
Leupeptin Hemisulfate
T6564CAS 103476-89-7
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
Loxistatin Acid
T6573CAS 76684-89-4
Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Z-FA-FMK
T6738CAS 197855-65-5
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
P005091
T6925CAS 882257-11-6
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
AX-024 HCl
T4403CAS 1704801-24-0
AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), inter...
NSC185058
T5211CAS 39122-38-8
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
2-cyano-Pyrimidine
T7451CAS 14080-23-0
2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
LY 3000328
TQ0116CAS 1373215-15-6
LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
MIV-247
T12051CAS 1352817-76-5
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
Cysteine protease inhibitor-2
T10924CAS 612048-23-4
Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT11...
S130
T12819CAS 1160852-22-1
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
SID 26681509
T12909CAS 958772-66-2
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
GLPG2451
T13705CAS 2055015-61-5
GLPG2451  effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.GLPG2451 is a cystic fibrosis transmembrane conductance regulat...
Cathepsin Inhibitor 2
T11554CAS 1017931-53-1
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor ,has a Ki of <20 nM. 
K777
T15641CAS 233277-99-1
K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is a...
(RS)-Butyryltimolol
T13439CAS NA
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is a β-adrenergic blocker.
ML-9 hydrochloride
T16104CAS 105637-50-1
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibi...
ML224
T16106CAS 1338824-21-7
ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
ONO-5334
T16394CAS 868273-90-9
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334...
Petesicatib
T16474CAS 1252637-35-6
Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
LHVS
T11846CAS 170111-28-1
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine prot...
LV-320
T11896CAS
LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 is a potent and uncompetitive AT...