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Cat No. | Product Name | Synonyms | Targets |
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T77484 | Atibuclimab | TNF | |
Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat amyotrophic lateral sclerosis. Atibuclimab reduces LPS-indu... | |||
T5354 | IRAK4-IN-7 | CA-4948 | IRAK |
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. | |||
T2690 | Tranilast | MK 341,SB 252218 | RAAS , Prostaglandin Receptor |
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders. | |||
T3520 | Setipiprant | KYTH-105,ACT-129968 | GPR , Prostaglandin Receptor |
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... | |||
T4403 | AX-024 hydrochloride | AX-024 HCl | IL Receptor , TNF , COX , IFNAR , Interleukin |
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | |||
T3701 | MCC950 | CP-456773 | NOD |
CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and... | |||
T70843 | Orazipone | ||
Orazipone inhibits cytokine production and histamine release; an NSAID. | |||
T11473 | GSK-5498A | Others | |
GSK-5498A is a selective blocker of CARC (IC50, 1 μM). It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species. | |||
T70346 | TOP1362 | ||
TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, bloc... | |||
TQ0032L | Rosiptor acetate | AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate | |
Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast ... | |||
T36401 | DCVC | ||
DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhib... | |||
T73667 | Motapizone | ||
Motapizone (NAT 05-239) is a selective PDE3 inhibitor that not only moderately reduces cytokine release in lipopolysaccharide (LPS)-stimulated alveolar macrophages but also suppresses human platelet aggregation by elevat... | |||
T77136 | Quisovalimab | ||
Quisovalimab (AVTX-002; AEVI 002; SAR 252067), a human monoclonal antibody targeting LIGHT, a tumor necrosis factor (TNF)-related cytokine (TNFSF14), is crucial for managing acute respiratory distress syndrome (ARDS) and... | |||
T74779 | JNJ-28583113 | ||
JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine rele... | |||
T79696 | JT001 sodium | NLRP3-IN-19 sodium | NOD-like Receptor (NLR) |
JT001 (NLRP3-IN-19) sodium is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome, thus curbing cytokine release and averting pyroptosis. It is utilized in research f... | |||
T79695 | NLRP3-IN-19 | NLRP3-IN-19 | NOD-like Receptor (NLR) |
JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the suppression of cytokine release and prevention of pyroptosis. J... | |||
T78032 | Endotoxin inhibitor TFA | ||
Endotoxin Inhibitor TFA is a synthetic peptide that exhibits high-affinity binding to lipid A, effectively detoxifying LPS and impeding LPS-induced cytokine release in vivo. It also suppresses the febrile response to LPS... | |||
T70377 | BAY 61-3606 HCl | ||
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh... | |||
T82254 | GSK-LSD1 | Histone Demethylase | |
GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (... | |||
T78803 | SIRT5 inhibitor 7 | Sirtuin | |
SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation and attenuating pro-inflammatory cytokine release. It demo... | |||
T62317 | α7 nAchR-JAK2-STAT3 agonist 1 | ||
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3795 | Corilagin | Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy | |
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B... | |||
T0798 | Triamcinolone | Fluoxyprednisolone,Aristocort,Rodinolone | Glucocorticoid Receptor , COX |
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca... | |||
TN5593 | Euphohelioscopin A | ||
Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it ex... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05039 | LTBR Protein, Human, Recombinant (hFc) | Human | HEK293 |
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necros... | |||
TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including ce... | |||
TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-03079 | IL-1R2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-01366 | IL-1R2 Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-00854 | IL-1 alpha/IL-1A Protein, Human, Recombinant | Human | HEK293 |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-06981 | IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) | Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-01738 | IL-1 alpha/IL-1A Protein, Mouse, Recombinant | Mouse | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPJ-00042 | TSLP Protein, Human, Recombinant | Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci... | |||
TMPY-02443 | HSP70 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upo... | |||
TMPY-00716 | CD89 Protein, Human, Recombinant (His) | Human | HEK293 |
FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This recep... | |||
TMPY-00916 | Antithrombin III Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog... | |||
TMPJ-01391 | BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc) | Mouse | Human Cells |
TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bo... | |||
TMPK-00116 | NKp80/KLRF1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release. | |||
TMPH-01550 | Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pa... | |||
TMPJ-00070 | IL-18 Protein, Human, Recombinant (His) | Human | Human Cells |
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The c... | |||
TMPK-00038 | TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi) | Human | HEK293 |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPK-00482 | TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPK-00039 | TSLP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPK-00040 | TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi), Biotinylated | Human | HEK293 |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPK-00037 | TSLP Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPY-03583 | LTBR Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necros... | |||
TMPY-02771 | LTBR Protein, Rat, Recombinant (His) | Rat | HEK293 |
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necros... | |||
TMPY-03252 | LTBR Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necros... | |||
TMPK-01325 | M-CSF/CSF1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPK-00322 | M-CSF/CSF1 Protein, Human, Recombinant (aa 33-190) | Human | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPJ-00117 | TREM-2 Protein, Human, Recombinant (mFc) | Human | Human Cells |
TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes r... | |||
TMPJ-00115 | TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | Human Cells |
TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes r... | |||
TMPJ-00028 | CCL2 Protein, Mouse, Recombinant | Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equ... | |||
TMPY-03254 | IL-1R2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPJ-01338 | TSLP Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family, contains 140 amino acids. It is known to play an important role in the maturation of T cell populations through activation of antigen pre... | |||
TMPY-02825 | IL-1R2 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-03078 | IL-1R2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-03904 | IL-1R2 Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPY-00848 | IL-1R2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPJ-00256 | Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are... | |||
TMPJ-00255 | TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated | Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are... | |||
TMPJ-00456 | APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in th... | |||
TMPY-03760 | CLEC5A Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPJ-00274 | LTBR Protein, Human, Recombinant (His) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,... | |||
TMPY-03872 | CLEC5A Protein, Rat, Recombinant (His) | Rat | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPY-03928 | CLEC5A Protein, Rhesus, Recombinant (mFc) | Rhesus | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPJ-01218 | M-CSF/CSF1 Protein, Rat, Recombinant | Rat | Human Cells |
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and different... | |||
TMPY-05836 | IL-1 alpha/IL-1A Protein, Rat, Recombinant | Rat | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPH-01723 | MYD88 Protein, Human, Recombinant (His) | Human | E. coli |
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the in... | |||
TMPJ-01060 | CXCL6 Protein, Human, Recombinant (His) | Human | Human Cells |
Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. It is a potent neutrophil chemotactic and activating factor and it exhibits extensive similarity to other CXC chemokines... | |||
TMPY-03623 | NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxic... | |||
TMPJ-00802 | THBS1 Protein, Human, Recombinant (His) | Human | Human Cells |
Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and w... | |||
TMPY-06092 | HSP70 Protein, Rat, Recombinant (His) | Rat | HEK293 |
HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upo... | |||
TMPY-02045 | SECTM1 Protein, Human, Recombinant (His) | Human | HEK293 |
Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern a... | |||
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Cat No. | Product Name | ||
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L5400 | Anti-Cardiovascular Disease Compound Library | 1428 compounds | |
A unique collection of 1428 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS); |