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DNA Damage/DNA Repair DNA Alkylation

DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.
Cat No. product name
T0377 Clofazimine Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and ...
T0707 Cyclophosphamide monohydrate Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T0923 Busulfan Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood...
T0942 Quinacrine dihydrochloride Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
T0975 Chloroambucil Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resul...
T1241 Altretamine Altretamine is an alkylating agent with antineoplastic activity.
T1250 Triethylenethiophosphoramide Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T1343L Crystal Violet Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
T1507 Streptozocin Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental anima...
T1548 8-Methoxypsoralen Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methox...
T1601 Lomustine Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
T2495 Lomeguatrib Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T3091 Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T3707 GNE-3511 GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T4024 Norharmane Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 t...
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T4368 Miriplatin Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T5846 Methylnitronitrosoguanidine Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
T7221 Satraplatin Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity agains...
T7539 O6-Benzylguanine O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T11056 DLK-IN-1 DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, r...
T19300 Duocarmycin Analog Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T12813L Seco-Duocarmycin SA Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T11440 GNE-8505 GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T17159 Treosulfan Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T17212 VAL-083 VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
Clofazimine
T0377CAS 2030-63-9
Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and ...
Cyclophosphamide monohydrate
T0707CAS 6055-19-2
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
Busulfan
T0923CAS 55-98-1
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood...
Quinacrine dihydrochloride
T0942CAS 69-05-6
Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
Hydroxychloroquine sulfate
T0951CAS 747-36-4
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
Chloroambucil
T0975CAS 305-03-3
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resul...
Altretamine
T1241CAS 645-05-6
Altretamine is an alkylating agent with antineoplastic activity.
Triethylenethiophosphoramide
T1250CAS 52-24-4
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Crystal Violet
T1343LCAS 548-62-9
Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
Streptozocin
T1507CAS 18883-66-4
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental anima...
8-Methoxypsoralen
T1548CAS 298-81-7
Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methox...
Lomustine
T1601CAS 13010-47-4
Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
Lomeguatrib
T2495CAS 192441-08-0
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
Carmustine
T3091CAS 154-93-8
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
GNE-3511
T3707CAS 1496581-76-0
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
Norharmane
T4024CAS 244-63-3
Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
Gemcitabine monophosphate sodium salt hydrate
T4187CAS 1638288-31-9
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Palifosfamide
T4350CAS 31645-39-3
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 t...
URMC-099
T6057CAS 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
Miriplatin
T4368CAS 141977-79-9
Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
Methylnitronitrosoguanidine
T5846CAS 70-25-7
Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
Satraplatin
T7221CAS 129580-63-8
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity agains...
O6-Benzylguanine
T7539CAS 19916-73-5
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
DLK-IN-1
T11056CAS 1620574-24-4
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, r...
Duocarmycin Analog
T19300CAS 372954-15-9
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
Seco-Duocarmycin SA
T12813LCAS 144667-38-9
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
GNE-8505
T11440CAS 1620573-48-9
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
Treosulfan
T17159CAS 299-75-2
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
VAL-083
T17212CAS 23261-20-3
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.