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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11120 | Duocarmycin TM | DNA Alkylation , Antibiotic | |
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. | |||
T0923 | Busulfan | Myleran,Sulphabutin,Busulphan | Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation |
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation... | |||
T1488 | Procarbazine hydrochloride | NSC-77213 HCl,Procarbazine HCl | DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba... | |||
T31551 | Mipicoledine | DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN | |
DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer. | |||
T10973 | DC41SMe | Others | |
DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used fo... | |||
T11118 | Duocarmycin SA | Others | |
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10018 | 1-Methyladenine | Others | |
1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02051 | RNF207 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M... |