Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and ...
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. |
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood...
Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. |
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resul...
Altretamine is an alkylating agent with antineoplastic activity. |
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity. |
Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties. |
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental anima...
Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methox...
Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors. |
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) . |
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent. |
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors. |
Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. |
||Gemcitabine monophosphate sodium salt hydrate
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine. |
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 t...
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC). |
Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects. |
Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity agains...
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, r...
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin. |
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin. |
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
Treosulfan is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types. |
VAL-083 is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity. |
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate...