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Chromatin/Epigenetic DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.
Cat No. product name
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
T1339 Mylosar Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
T1508 DecitabineHOT Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
T1904 SGI-1027 SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, resp...
T2038 RG108 RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
T2169 Zebularine Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates....
T3089 Thioguanine Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T3458 EED226 EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
T5198 Bobcat339 hydrochloride Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
T7718 2'-DEOXY-5-FLUOROCYTIDINE 2'-DEOXY-5-FLUOROCYTIDINE is an  inhibitor of DNA methyltransferase (DNMT) .
T7194 CM-272 CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. 
T10840L CM-579 CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T15080 DC-05 DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50: 10.3 μM; Kd: 1.09 μM).
T15081 DC_517 DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T12790 Guadecitabine sodium Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T11469 GSK-3484862 GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 is a non-covalent inhibitor for Dnmt1. 
T13954 UNC6852 UNC6852 is a selective degrader of PRC2 based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand(EED, IC50 of 247 nM).
T10840 CM-579 trihydrochloride CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide...
T19383 Isomaltotriose Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
T16287 Neurodazine Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte different...
Procainamide hydrochloride
T0018CAS 614-39-1
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
Mylosar
T1339CAS 320-67-2
Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
Decitabine HOT
T1508CAS 2353-33-5
Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
SGI-1027
T1904CAS 1020149-73-8
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, resp...
RG108
T2038CAS 48208-26-0
RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
Zebularine
T2169CAS 3690-10-6
Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates....
Thioguanine
T3089CAS 154-42-7
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
EED226
T3458CAS 2083627-02-3
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
Bobcat339 hydrochloride
T5198CAS 2280037-51-4
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
2'-DEOXY-5-FLUOROCYTIDINE
T7718CAS 10356-76-0
2'-DEOXY-5-FLUOROCYTIDINE is an  inhibitor of DNA methyltransferase (DNMT) .
CM-272
T7194CAS 1846570-31-7
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. 
CM-579
T10840LCAS 1846570-40-8
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
DC-05
T15080CAS 890643-16-0
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50: 10.3 μM; Kd: 1.09 μM).
DC_517
T15081CAS 500017-70-9
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
Guadecitabine sodium
T12790CAS 929904-85-8
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
GSK-3484862
T11469CAS 2170136-65-7
GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 is a non-covalent inhibitor for Dnmt1. 
UNC6852
T13954CAS
UNC6852 is a selective degrader of PRC2 based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand(EED, IC50 of 247 nM).
CM-579 trihydrochloride
T10840CAS
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide...
Isomaltotriose
T19383CAS 3371-50-4
Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
Neurodazine
T16287CAS 937807-66-4
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte different...