Home Tools
Log in
Cart

Search Result

Search Results for " dna-methyltransferase "

Targets

35

Compounds

7

Natural Products

17

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1904 SGI-1027 DNA Methyltransferase Inhibitor II,SGI1027 Apoptosis , DNA Methyltransferase
SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.
T15080 DC-05 DNA Methyltransferase , Histone Methyltransferase
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
T7194 CM-272 Apoptosis , DNA Methyltransferase , Histone Methyltransferase
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T11469 GSK-3484862 DNA Methyltransferase
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
T2495 Lomeguatrib PaTrin-2 DNA Methyltransferase , DNA Alkylation
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T7718 5-Fluoro-2'-deoxycytidine FdCyd,2'-DEOXY-5-FLUOROCYTIDINE DNA Methyltransferase
5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .
T5198 Bobcat339 Bobcat339 hydrochloride DNA Methyltransferase
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
T8967 SW155246 DNA Methyltransferase
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
T9573 GSK3685032 DNA Methyltransferase
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...
T2169 Zebularine NSC309132,4-Deoxyuridine DNA Methyltransferase , Autophagy
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2...
T2038 RG108 N-Phthalyl-L-tryptophan DNA Methyltransferase
RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).
T7840 2',3',5'-triacetyl-5-Azacytidine Nsc291930 DNA Methyltransferase , Others
2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
T0192 Levetiracetam UCB L059,SIB-S1 DNA Methyltransferase , Others , Calcium Channel
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...
T3089 6-Thioguanine 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T16269 Nanaomycin A DNA Methyltransferase , Dehydrogenase , Parasite
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
TNU0425 2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride DNA Methyltransferase
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabolic and antitumor activity.
T28663 Sarmustine NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432
Sarmustine (SarCNU) is an alkylating agent with anticancer activity that inhibits the growth of prostate cancer cells via p53-dependent and p53-independent pathways.Sarmustine mediates the selection of P140K methylguanin...
T60322 Procainamide Biocoryl,Novocainamide DNA Methyltransferase
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmia...
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T10840L CM-579 DNA Methyltransferase , Histone Methyltransferase
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T25594 Laccaic acid A
Laccaic acid A is a direct, DNA-competitive DNA methyltransferase 1 inhibitor.
T23968 DC_501 DC 501,DC501
DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.
T26496 AA-CW236 AA-CW 236,AACW-236,AACW236,AACW 236,AA-CW-236
AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).
T15081 DC_517 DNA Methyltransferase
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T60476 2′-Deoxy-5-nitrocytidine
2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].
T62643 DY-46-2
DY-46-2 is a highly selective, potent, novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 1.3 μM).
T40560 Benzyl selenocyanate
Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methylt...
T27395 Furamidine dihydrochloride DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site ...
T82614 DAM-IN-1 DNA/RNA Synthesis
DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM. It effectively inhibits Caulobacter growth, exhibiting a minimum inhibitory concentration (MIC) of 35 μM [1].
T11338 Furamidine DB75,NSC 305831 Others
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...
T36100 K-TMZ
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lin...
T73274 CamA-IN-1
CamA-IN-1 is a Clostridioides difficile -specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC 50 and K d values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for ...
T35413 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in...
T79035 PRMT5-IN-28 Histone Methyltransferase
PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes including gene transcription, mRNA splicing, DNA repair, prot...
T10840 CM-579 trihydrochloride (1846570-40-8 free base) CM-579 trihydrochloride DNA Methyltransferase
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.

Compounds

SGI-1027
T1904
Synonym: DNA Methyltransferase Inhibitor II,SGI1027
Target: Apoptosis, DNA Methyltransferase
DC-05
T15080
Synonym:
Target: DNA Methyltransferase, Histone Methyltransferase
CM-272
T7194
Synonym:
Target: Apoptosis, DNA Methyltransferase, Histone Methyltransferase
GSK-3484862
T11469
Synonym:
Target: DNA Methyltransferase
Lomeguatrib
T2495
Synonym: PaTrin-2
Target: DNA Methyltransferase, DNA Alkylation
5-Fluoro-2'-deoxycytidine
T7718
Synonym: FdCyd,2'-DEOXY-5-FLUOROCYTIDINE
Target: DNA Methyltransferase
Bobcat339
T5198
Synonym: Bobcat339 hydrochloride
Target: DNA Methyltransferase
SW155246
T8967
Synonym:
Target: DNA Methyltransferase
GSK3685032
T9573
Synonym:
Target: DNA Methyltransferase
Zebularine
T2169
Synonym: NSC309132,4-Deoxyuridine
Target: DNA Methyltransferase, Autophagy
RG108
T2038
Synonym: N-Phthalyl-L-tryptophan
Target: DNA Methyltransferase
2',3',5'-triacetyl-5-Azacytidine
T7840
Synonym: Nsc291930
Target: DNA Methyltransferase, Others
Levetiracetam
T0192
Synonym: UCB L059,SIB-S1
Target: DNA Methyltransferase, Others, Calcium Channel
6-Thioguanine
T3089
Synonym: 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine
Target: Apoptosis, DNA Methyltransferase, SARS-CoV, Endogenous Metabolite, DUB, Autophagy
Nanaomycin A
T16269
Synonym:
Target: DNA Methyltransferase, Dehydrogenase, Parasite
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride
TNU0425
Synonym:
Target: DNA Methyltransferase
Sarmustine
T28663
Synonym: NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432
Target:
Procainamide
T60322
Synonym: Biocoryl,Novocainamide
Target: DNA Methyltransferase
Hydralazine hydrochloride
T1613
Synonym: Hydralazine HCl,Apresoline
Target: MAO, HIF/HIF Prolyl-Hydroxylase
CM-579
T10840L
Synonym:
Target: DNA Methyltransferase, Histone Methyltransferase
Laccaic acid A
T25594
Synonym:
Target:
DC_501
T23968
Synonym: DC 501,DC501
Target:
AA-CW236
T26496
Synonym: AA-CW 236,AACW-236,AACW236,AACW 236,AA-CW-236
Target:
DC_517
T15081
Synonym:
Target: DNA Methyltransferase
2′-Deoxy-5-nitrocytidine
T60476
Synonym:
Target:
DY-46-2
T62643
Synonym:
Target:
Benzyl selenocyanate
T40560
Synonym:
Target:
Furamidine dihydrochloride
T27395
Synonym: DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
Target:
DAM-IN-1
T82614
Synonym:
Target: DNA/RNA Synthesis
Furamidine
T11338
Synonym: DB75,NSC 305831
Target: Others
K-TMZ
T36100
Synonym:
Target:
CamA-IN-1
T73274
Synonym:
Target:
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
T35413
Synonym:
Target:
PRMT5-IN-28
T79035
Synonym:
Target: Histone Methyltransferase
CM-579 trihydrochloride (1846570-40-8 free base)
T10840
Synonym: CM-579 trihydrochloride
Target: DNA Methyltransferase
Cat No. Product Name Synonyms Targets
T3606 γ-Oryzanol Gamma-Oryzanol,Oliver,Gammariza DNA Methyltransferase
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b...
T3717 Hinokitiol 4-Isopropyltropolone,β-thujaplicin DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2
Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent...
T7457 5-Methyl-2'-deoxycytidine 5-Methyldeoxycytidine,5MedCyd DNA Methyltransferase , Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
T1508 Decitabine Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine Apoptosis , Nucleoside Antimetabolite/Analog , DNA Methyltransferase
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis...
T1339 5-Azacytidine Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-AzaC Nucleoside Antimetabolite/Analog , DNA Methyltransferase , Antibacterial , Antibiotic , Autophagy
5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autopha...
T2988 (-)-Epigallocatechin Gallate Epigallocatechol Gallate,EGCG Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
T4909 N-Acetyl-DL-methionine Others , Endogenous Metabolite
N-acetyl-L-methionine is nutritionally and metabolically equivalent to L-methionine. Methionine is a dietary indispensable amino acid required for normal growth and development of humans, other mammals, and avian species...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00872 MGMT Protein, Human, Recombinant (His) Human E. coli
MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs al...
TMPY-02420 HEMK2 Protein, Human, Recombinant (His) Human E. coli
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to t...
TMPY-01306 DNMT2 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
DNMT2, also known as tRNA (cytosine-5-)-methyltransferase, DNA methyltransferase homolog HsaIIP, and TRDMT1, is a member of the DNA methyltransferase family of enzymes. DNMT2 enzymes have been widely conserved during evo...
TMPY-01284 METTL11A Protein, Human, Recombinant (GST) Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPY-01285 METTL11A Protein, Human, Recombinant Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPH-01681 METTL4 Protein, Human, Recombinant (His & Myc) Human E. coli
N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U...
TMPY-01708 DOT1L Protein, Human, Recombinant Human E. coli
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil...
TMPY-03046 APCDD1 Protein, Human, Recombinant (hFc) Human HEK293
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res...
TMPY-01383 PRMT6 Protein, Human, Recombinant (His & Flag) Human HEK293
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex...
TMPY-05693 SARS-CoV-2 Methyltransferase/ME Protein (His) SARS-CoV-2 E. coli
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate...
TMPJ-01118 GNMT Protein, Human, Recombinant (His) Human E. coli
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation b...
TMPJ-01040 MAX Protein, Human, Recombinant (His) Human E. coli
Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lun...
TMPY-01265 RIZ1 Protein, Human, Recombinant (GST) Human E. coli
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ...
TMPY-01272 RIZ1 Protein, Human, Recombinant Human E. coli
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ...
TMPY-02888 MAX Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to the MAX family. It is highly expressed in the brain, heart, and lung while lower levels are seen in the liver, kidney, and skeletal m...
TMPH-01734 METTL3 Protein, Human, Recombinant (His) Human E. coli
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of emb...
TMPH-00385 Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) CHIKV E. coli
Inactive precursor of the viral replicase, which is activated by cleavages carried out by the viral protease nsP2.; The early replication complex formed by the polyprotein P123 and nsP4 synthesizes minus-strand RNAs. As ...
MGMT Protein, Human, Recombinant (His)
TMPJ-00872
Species: Human
Expression System: E. coli
HEMK2 Protein, Human, Recombinant (His)
TMPY-02420
Species: Human
Expression System: E. coli
DNMT2 Protein, Human, Recombinant (GST)
TMPY-01306
Species: Human
Expression System: Baculovirus-Insect Cells
METTL11A Protein, Human, Recombinant (GST)
TMPY-01284
Species: Human
Expression System: E. coli
METTL11A Protein, Human, Recombinant
TMPY-01285
Species: Human
Expression System: E. coli
METTL4 Protein, Human, Recombinant (His & Myc)
TMPH-01681
Species: Human
Expression System: E. coli
DOT1L Protein, Human, Recombinant
TMPY-01708
Species: Human
Expression System: E. coli
APCDD1 Protein, Human, Recombinant (hFc)
TMPY-03046
Species: Human
Expression System: HEK293
PRMT6 Protein, Human, Recombinant (His & Flag)
TMPY-01383
Species: Human
Expression System: HEK293
SARS-CoV-2 Methyltransferase/ME Protein (His)
TMPY-05693
Species: SARS-CoV-2
Expression System: E. coli
GNMT Protein, Human, Recombinant (His)
TMPJ-01118
Species: Human
Expression System: E. coli
MAX Protein, Human, Recombinant (His)
TMPJ-01040
Species: Human
Expression System: E. coli
RIZ1 Protein, Human, Recombinant (GST)
TMPY-01265
Species: Human
Expression System: E. coli
RIZ1 Protein, Human, Recombinant
TMPY-01272
Species: Human
Expression System: E. coli
MAX Protein, Human, Recombinant (His & GST)
TMPY-02888
Species: Human
Expression System: Baculovirus-Insect Cells
METTL3 Protein, Human, Recombinant (His)
TMPH-01734
Species: Human
Expression System: E. coli
Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His)
TMPH-00385
Species: CHIKV
Expression System: E. coli
TargetMol