Search Result

Search Results for " dna-pk "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2433	NU 7026	NU7026,DNA-PK Inhibitor II,LY293646	Apoptosis , ATM/ATR , DNA-PK , PI3K
	NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.		Apoptosis , ATM/ATR , DNA-PK , PI3K
T15789	LTURM34		DNA-PK , PI3K , PI4K
	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .		DNA-PK , PI3K , PI4K
T4339	YU238259		DNA-PK , Others
	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.		DNA-PK , Others
T2461	PIK-90		DNA-PK , PI3K
	PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .		DNA-PK , PI3K
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
T3986	SF2523		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
	SF2523 is a highly selective and potent inhibitor.		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
T3541	CC-115	CC 115	DNA-PK , PI3K , mTOR
	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).		DNA-PK , PI3K , mTOR
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T79165	DNA-PK-IN-10		DNA-PK
	DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].		DNA-PK
T61751	DNA-PK-IN-3
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tum...
T9760	IC 86621		DNA-PK
	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell...		DNA-PK
T62034	DNA-PK-IN-7
	DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).
T62191	DNA-PK-IN-5
	DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits the activity of DNA-PKcs, significantly reduces tumour DNA repair and induces apoptosis. DNA-PK-IN-5 improves the sensitivity of tumour tissue to radiothe...
T61857	DNA-PK-IN-4
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly imp...
T62648	DNA-PK-IN-1
	DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.
T61633	DNA-PK-IN-2
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications i...
T61533	DNA-PK-IN-9
	DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
T61370	DNA-PK-IN-6
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli...
T61828	DNA-PK-IN-8
	DNA-PK-IN-8 is a potent, selective, and orally active inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.8 nM. It displays synergistic antiproliferative effects across various cancer cel...
T6557	KU-0060648	KU0060648	DNA-PK , PI3K , mTOR
	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.		DNA-PK , PI3K , mTOR
T6276	KU-57788	NU7441	DNA-PK , CRISPR/Cas9
	NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).		DNA-PK , CRISPR/Cas9
T2667	PIK-75		Apoptosis , DNA-PK , PI3K
	PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).		Apoptosis , DNA-PK , PI3K
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T25399	ETP-45658	ETP45658,ETP 45658	DNA-PK , PI3K , mTOR
	ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively...		DNA-PK , PI3K , mTOR
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T3586	Compound 401	2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	DNA-PK
	Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.		DNA-PK
T6883	Samotolisib	GTPL8918,LY3023414	DNA-PK , PI3K , mTOR , Autophagy
	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ...		DNA-PK , PI3K , mTOR , Autophagy
T25069	AMA-37	DNA-PK Inhibitor V,ArylMorpholine Analog 37,AMA 37
	AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.
T13017	STL127705	Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK , Others
	STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM.		DNA-PK , Others
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T2287	PIK-75 hydrochloride	PIK-75 HCl,PIK-75	Apoptosis , DNA-PK , PI3K
	PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.		Apoptosis , DNA-PK , PI3K
TQ0031	Nedisertib	M3814	DNA-PK
	Nedisertib (M3814) (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).		DNA-PK
T9498	BAY-8400		DNA-PK
	BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combination with targeted alpha therapies. BAY-8400 can be used for...		DNA-PK
T1826	PI3K-IN-1	Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK , PI3K
	PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.		DNA-PK , PI3K
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T7014	Voxtalisib	XL765,SAR245409	DNA-PK , PI3K , mTOR
	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.		DNA-PK , PI3K , mTOR
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T8637	DMNB	6-Nitroveratraldehyde	DNA-PK
	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...		DNA-PK
T8651	CAL-101	(S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib	PI3K
	CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than...		PI3K
T11067	VX-984	M9831	DNA-PK
	VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo...		DNA-PK
T2415	PP121		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
	PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM).		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
T6319	OSI-027	ASP4786,OSI027	DNA-PK , PI3K , mTOR , Autophagy
	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.		DNA-PK , PI3K , mTOR , Autophagy
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T12672	(Rac)-Nedisertib	(Rac)-M3814	DNA-PK
	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).		DNA-PK
T13444	(R)-Nedisertib	(R)-M3814	Others
	(R)-Nedisertib is a less active R-enantiomer of Nedisertib(IC50 in the range of 7-30 nM for DNA-PK).		Others
T6283	Wortmannin	SL-2052,KY-12420	ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy
	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
T68192	OK-1035
	OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of conse...
T24559	NU-7163	NU 7163,NU7163
	NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.
T69286	IC87361
	IC87361 is a potent and specific inhibitor of DNA-PK.

Compounds

NU 7026

T2433

Synonym: NU7026,DNA-PK Inhibitor II,LY293646

Target: Apoptosis, ATM/ATR, DNA-PK, PI3K

LTURM34

T15789

Synonym:

Target: DNA-PK, PI3K, PI4K

YU238259

T4339

Synonym:

Target: DNA-PK, Others

PIK-90

T2461

Synonym:

Target: DNA-PK, PI3K

Torin 2

T6100

Synonym:

Target: Apoptosis, ATM/ATR, DNA-PK, mTOR, Autophagy

SF2523

T3986

Synonym:

Target: DNA-PK, Epigenetic Reader Domain, PI3K, mTOR

CC-115

T3541

Synonym: CC 115

Target: DNA-PK, PI3K, mTOR

PK11000

T4459

Synonym:

Target: DNA Alkylator/Crosslinker

Target: DNA-PK, PI3K, mTOR

KU-57788

T6276

Synonym: NU7441

Target: DNA-PK, CRISPR/Cas9

PIK-75

T2667

Synonym:

Target: Apoptosis, DNA-PK, PI3K

PI-103

T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

ETP-45658

T25399

Synonym: ETP45658,ETP 45658

Target: DNA-PK, PI3K, mTOR

Synonym: 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

Target: DNA-PK

Samotolisib

T6883

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

AMA-37

T25069

Synonym: DNA-PK Inhibitor V,ArylMorpholine Analog 37,AMA 37

Target:

STL127705

T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

LY294002

T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

PIK-75 hydrochloride

T2287

Synonym: PIK-75 HCl,PIK-75

Target: Apoptosis, DNA-PK, PI3K

Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409

Target: DNA-PK, PI3K

NU6027

T6612

Synonym:

Target: ATM/ATR, DNA-PK, CDK

Voxtalisib

T7014

Synonym: XL765,SAR245409

Target: DNA-PK, PI3K, mTOR

Camonsertib

T62083

Synonym: ATR inhibitor 4,RP-3500

Target: ATM/ATR

DMNB

T8637

Synonym: 6-Nitroveratraldehyde

Target: DNA-PK

CAL-101

T8651

Synonym: (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib

Target: Apoptosis, VEGFR, Bcr-Abl, PDGFR, Src, mTOR, Hck

OSI-027

T6319

Synonym: ASP4786,OSI027

Target: DNA-PK, PI3K, mTOR, Autophagy

KU-55933

T2685

Synonym: ATM Kinase Inhibitor

Target: ATM/ATR, DNA-PK, PI3K, mTOR, Autophagy

Synonym: SL-2052,KY-12420

Target: ATM/ATR, DNA-PK, Serine/threonin kinase, PLK, PI3K, Antibiotic, Autophagy

Synonym: NU 7163,NU7163

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00476	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc)	Dictyostelium discoideum	E. coli
	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli.
TMPY-02287	Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPY-01188	PARP Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPY-02465	PARP Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...