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DNA Damage/DNA Repair DNA/RNA Synthesis

DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat No. product name
T0095 Bendamustine hydrochloride Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T0148 Calcium folinate Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T0164 Oxaliplatin Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
T0189 Pemetrexed acid Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T0189L Pemetrexed disodium Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
T0251 GemcitabineHOT Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0297 Clofarabine Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = ...
T0353 Osalmid Osalmid is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
T0415 Guanidine hydrochloride Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0676 Hydroxyurea Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T0681 Rifampicin Rifampicin is an antibacterial drug of the class of rifamycin.
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0926 Azelaic acid Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
T0964 Floxuridine Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T0984 FluorouracilHOT Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
T0986 Fluorocytosine Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
T1055 Ifosfamide Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mu...
T1058 Carboplatin Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
T1086 Vitamin D2 Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder...
T1087 Valacyclovir hydrochloride Valacyclovir is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
T1120 Dacarbazine Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T1153 Trimethoprim Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
T1154 Rifaximin Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-s...
T1178 TemozolomideHOT Temozolomide is a DNA alkylating agent interfering with DNA replication.
T1233 Oxolinic acid Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
T1272 Cytarabine Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterica...
T1276 Danofloxacin mesylate Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
T1307 Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopa...
T1349 5-Fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to ...
T1378 Tegafur Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the...
T1408 Capecitabine Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively a...
T1428 Trifluridine Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, ...
T1454 Aciclovir Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoste...
T1465 Mupirocin Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
T1488 Procarbazine hydrochloride Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cy...
T1501 Rifabutin Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
T1506 Vidarabine Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA...
T1511 Daunorubicin hydrochloride Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T1591 Cyclocytidine hydrochloride Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydr...
T1600 Doxifluridine Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, design...
T1617 Enrofloxacin Enrofloxacin is a veterinary antibacterial agent, used in poultry.
T1629 Rifapentine Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
T1646 Famciclovir Famciclovir is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and D...
T1663 Deoxythymidine triphosphate Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
T1665 Daptomycin Daptomycin is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
T1679 Thiostrepton Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastit...
T1721 2'-Deoxyuridine 2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagno...
T1724 SCR7 pyrazine SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
T1767 BMH-21 BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.
Bendamustine hydrochloride
T0095CAS 3543-75-7
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
Calcium folinate
T0148CAS 1492-18-8
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
Oxaliplatin
T0164CAS 61825-94-3
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
Pemetrexed acid
T0189CAS 137281-23-3
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
Pemetrexed disodium
T0189LCAS 150399-23-8
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
Gemcitabine HOT
T0251CAS 95058-81-4
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Clofarabine
T0297CAS 123318-82-1
Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = ...
Osalmid
T0353CAS 526-18-1
Osalmid is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
Guanidine hydrochloride
T0415CAS 50-01-1
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
Hydroxyurea
T0676CAS 127-07-1
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Rifampicin
T0681CAS 13292-46-1
Rifampicin is an antibacterial drug of the class of rifamycin.
Ribavirin
T0684CAS 36791-04-5
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Azelaic acid
T0926CAS 123-99-9
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
Floxuridine
T0964CAS 50-91-9
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Fluorouracil HOT
T0984CAS 51-21-8
Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
Fluorocytosine
T0986CAS 2022-85-7
Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
Ifosfamide
T1055CAS 3778-73-2
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mu...
Carboplatin
T1058CAS 41575-94-4
Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
Vitamin D2
T1086CAS 50-14-6
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder...
Valacyclovir hydrochloride
T1087CAS 124832-27-5
Valacyclovir is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
Dacarbazine
T1120CAS 4342-03-4
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
Trimethoprim
T1153CAS 738-70-5
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
Rifaximin
T1154CAS 80621-81-4
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-s...
Temozolomide HOT
T1178CAS 85622-93-1
Temozolomide is a DNA alkylating agent interfering with DNA replication.
Oxolinic acid
T1233CAS 14698-29-4
Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
Cytarabine
T1272CAS 147-94-4
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterica...
Danofloxacin mesylate
T1276CAS 119478-55-6
Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
Carmofur
T1307CAS 61422-45-5
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopa...
5-Fluorouridine
T1349CAS 316-46-1
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to ...
Tegafur
T1378CAS 17902-23-7
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the...
Capecitabine
T1408CAS 154361-50-9
Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively a...
Trifluridine
T1428CAS 70-00-8
Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, ...
Aciclovir
T1454CAS 59277-89-3
Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoste...
Mupirocin
T1465CAS 12650-69-0
Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
Procarbazine hydrochloride
T1488CAS 366-70-1
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cy...
Rifabutin
T1501CAS 72559-06-9
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
Vidarabine
T1506CAS 5536-17-4
Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA...
Daunorubicin hydrochloride
T1511CAS 23541-50-6
Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Cyclocytidine hydrochloride
T1591CAS 10212-25-6
Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydr...
Doxifluridine
T1600CAS 3094-09-5
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, design...
Enrofloxacin
T1617CAS 93106-60-6
Enrofloxacin is a veterinary antibacterial agent, used in poultry.
Rifapentine
T1629CAS 61379-65-5
Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
Famciclovir
T1646CAS 104227-87-4
Famciclovir is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and D...
Deoxythymidine triphosphate
T1663CAS 18423-43-3
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
Daptomycin
T1665CAS 103060-53-3
Daptomycin is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
Thiostrepton
T1679CAS 1393-48-2
Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastit...
2'-Deoxyuridine
T1721CAS 951-78-0
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagno...
SCR7 pyrazine
T1724CAS 14892-97-8
SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
BMH-21
T1767CAS 896705-16-1
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.