| T0095 |
Bendamustine hydrochloride |
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage. |
| T0148 |
Calcium folinate |
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists. |
| T0164 |
Oxaliplatin |
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts. |
| T0189 |
Pemetrexed acid |
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS). |
| T0189L |
Pemetrexed disodium |
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
|
| T0251 |
GemcitabineHOT |
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy. |
| T0297 |
Clofarabine |
Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 6...
|
| T0353 |
Osalmid |
Osalmid is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2). |
| T0415 |
Guanidine hydrochloride |
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
|
| T0676 |
Hydroxyurea |
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. |
| T0681 |
Rifampicin |
Rifampicin is an antibacterial drug of the class of rifamycin. |
| T0684 |
Ribavirin |
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. |
| T0926 |
Azelaic acid |
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
|
| T0964 |
Floxuridine |
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
| T0984 |
FluorouracilHOT |
Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. |
| T0986 |
Fluorocytosine |
Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. |
| T1038 |
FludarabineHOT |
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor. |
| T1055 |
Ifosfamide |
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mu...
|
| T1058 |
Carboplatin |
Carboplatin is an organoplatinum compound that possesses antineoplastic activity. |
| T1086 |
Vitamin D2 |
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder...
|
| T1087 |
Valacyclovir hydrochloride |
Valacyclovir is an acyclovir prodrug that inhibits viral DNA replication after metabolization. |
| T1120 |
Dacarbazine |
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas. |
| T1153 |
Trimethoprim |
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
|
| T1154 |
Rifaximin |
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-s...
|
| T11600 |
IBR2 |
IBR2 is a specific RAD51 inhibitor. |
| T1178 |
TemozolomideHOT |
Temozolomide is a DNA alkylating agent interfering with DNA replication. |
| T12006 |
Metarrestin |
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts ...
|
| T1233 |
Oxolinic acid |
Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. |
| T12682 |
RAD51-IN-2 |
RAD51-IN-2 is a inhibitor of RAD51. |
| T1272 |
Cytarabine |
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterica...
|
| T1276 |
Danofloxacin mesylate |
Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase. |
| T1307 |
Carmofur |
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopa...
|
| T13479 |
2-Keto-D-galactose |
2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells. |
| T1349 |
5-Fluorouridine |
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to ...
|
| T13584 |
BMVC-8C3O |
BMVC-8C3O is a DNA G-quadruplexe (G4) ligand, can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. |
| T1378 |
Tegafur |
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the...
|
| T1408 |
Capecitabine |
Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively a...
|
| T1417 |
Mechlorethamine hydrochloride |
Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication. |
| T1428 |
Trifluridine |
Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, ...
|
| T1454 |
Aciclovir |
Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoste...
|
| T1465 |
Mupirocin |
Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci. |
| T1488 |
Procarbazine hydrochloride |
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cy...
|
| T1501 |
Rifabutin |
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
|
| T1506 |
Vidarabine |
Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA...
|
| T15094 |
Dehydroaltenusin |
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits...
|
| T1511 |
Daunorubicin hydrochloride |
Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis. |
| T15235 |
Enocitabine |
Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegaloviru...
|
| T1558 |
ResveratrolHOT |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. |
| T15611 |
JH-RE-06 |
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor...
|
| T1564 |
CisplatinHOT |
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells. |
| T1591 |
Cyclocytidine hydrochloride |
Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydr...
|
| T1600 |
Doxifluridine |
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, design...
|
| T1617 |
Enrofloxacin |
Enrofloxacin is a veterinary antibacterial agent, used in poultry. |
| T1629 |
Rifapentine |
Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections. |
| T1646 |
Famciclovir |
Famciclovir is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and D...
|
| T1663 |
Deoxythymidine triphosphate |
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. |
| T1665 |
Daptomycin |
Daptomycin is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA. |
| T16749 |
Rifalazil |
Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polyme...
|
| T1679 |
Thiostrepton |
Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastit...
|
| T1703 |
SN38 |
SN-38 is an active metabolite of CPT-11. |
| T17071 |
Thiarabine |
Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis. |
| T1721 |
2'-Deoxyuridine |
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagno...
|
| T1724 |
SCR7 pyrazine |
Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ). |
| T1767 |
BMH21 |
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. |
| T1840 |
Isoindigotin |
Isoindigotin is used in the therapy of Y. |
| T1982 |
Triapine |
Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR). |
| T19833 |
5-Fluoroorotic acid |
5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-exp...
|
| T20945 |
2,4-D |
2,4-Dichlorophenoxyacetic acid is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ...
|
| T2100 |
CX5461 |
CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA. |
| T2201 |
6-Mercaptopurine monohydrate |
6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually i...
|
| T2219 |
Puromycin dihydrochloride |
Puromycin hydrochloride is a cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and...
|
| T22429 |
SR18662 |
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cance...
|
| T22443 |
Triglycidyl Isocyanurate |
Triglycidyl Isocyanurate, a triazene triepoxide with antineoplastic activity, could inhibit growth of human non-small cell lung cancer cells by activating p53. ...
|
| T2275 |
YK-4-279 |
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1. |
| T2276 |
RI1 |
RI-1 is a RAD51 inhibitor (IC50: 5-30 μM). |
| T2410 |
Nedaplatin |
Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate...
|
| T2504 |
Pritelivir |
Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM). |
| T2627 |
Nolatrexed dihydrochloride |
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatre...
|
| T2628 |
RI2 |
RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in h...
|
| T2708 |
SL327 |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. |
| T2942 |
Psoralen |
Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. |
| T3157 |
COH29 |
COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activit...
|
| T3340 |
SCR7 |
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ). |
| T3343 |
5-methoxyflavone |
5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities. |
| T3400 |
Bakuchiol |
Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has ...
|
| T3524 |
Halofuginone hydrobromide |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression o...
|
| T3628 |
Madrasin |
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. |
| T3658 |
TAS102 |
TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1. |
| T3772 |
Maslinic acid |
Maslinic acid is a DNA polymerase B inhibitor. |
| T4010 |
Juglone |
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidy...
|
| T4060 |
Acelarin |
Acelarin (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine. |
| T4187 |
Gemcitabine monophosphate sodium salt hydrate |
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine. |
| T4226 |
Amenamevir |
Amenamevir is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL). |
| T4228 |
Nolatrexed |
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity. |
| T4311 |
HAMNO |
HAMNO is a protein interaction inhibitor of replication protein A (RPA). |
| T4336 |
IPTG |
IPTG is a non-metabolizable galactose analog that induces expression of the LAC OPERON. |
| T4356 |
Compound 3A |
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II. |
| T4382 |
Proguanil hydrochloride |
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted...
|
| T4457 |
Pyridostatin Trihydrochloride(free base 1085412-37-8 ) |
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
| T4470 |
Pyridostatin TFA |
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-k...
|
| T4517 |
L189 |
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM). |
| T4569 |
Lucanthone |
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
| T4641 |
LMI 070 |
LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
| T4656 |
B02 |
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. |
| T4687 |
Ro 5-3335 |
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/C...
|
| T5413 |
ML216 |
ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (...
|
| T5942 |
Docosanoic acid |
Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils. |
| T6069 |
Gemcitabine HClHOT |
Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively). |
| T6116 |
Bleomycin Sulfate |
Bleomycin Sulfate, a glycopeptide antibiotic, is an anticancer agent for squamous cell carcinomas (SCC). In UT-SCC-19A cells, the IC50 of Bleomycin Sulfate is 4...
|
| T6194 |
Fidaxomicin |
Fidaxomicin is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorpti...
|
| T6225 |
Adenine hydrochloride |
Adenine HCl is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry. |
| T6226 |
Pemetrexed Disodium Hydrate |
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is...
|
| T6244 |
Cidofovir |
Cidofovir inhibits virus replication by specific inhibition of viral DNA synthesis. |
| T6369 |
Adenine sulfate |
Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| T6446 |
Clevudine |
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolit...
|
| T6456 |
CRT0044876 |
CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
| T6501 |
Fludarabine Phosphate |
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic acti...
|
| T6603 |
Nelarabine |
Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
| T6632 |
Raltitrexed |
Raltitrexed（IC50 of 9 nM）, a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth. |
| T6752 |
Ademetionine disulfate tosylate |
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-infl...
|
| T6753 |
AI-10-49 |
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. |
| T6823 |
E3330 |
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
| T6856 |
Halofuginone |
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase（Ki=18.3 nM）, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in th...
|
| T6894 |
ML264 |
ML264 is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer. |
| T6908 |
NSC228155 |
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation. |
| T6974 |
Saccharin 1-methylimidazole (SMI) |
SMI is a general-purpose activator used for DNA and RNA synthesis. |
| T6S0139 |
Neobavaisoflavone |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases....
|
| T7004 |
Tubercidin |
Tubercidin, an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA ...
|
| T7174 |
Urolithin A |
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties. |
| T7429 |
Datelliptium chloride |
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities. |
| T7525 |
Didox |
Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients...
|
| T7655 |
Fialuridine |
Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro an...
|
| T7747 |
Datelliptium chloride hydrochloride |
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities. |
| T8647 |
BCH001 |
BCH001 is a specific small-molecule inhibitor of PAPD5. |
| T8785 |
HALOFUGINONE LACTATE |
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone...
|
| T8800 |
NSAH |
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively. |
| T8886 |
NITD-2 |
NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DE...
|
| TL0005 |
(-)-3,5-Dicaffeoyl quinic acid |
3,5-Dicaffeoylquinic acid is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and...
|
| TMA0291 |
Dehydroglyasperin D |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
|
| TMA0984 |
Cerevisterol |
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. |
| TN1016 |
Kukoamine A |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidativ...
|
| TN1244 |
3'-Demethylnobiletin |
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle ...
|
| TN1258 |
3-O-Acetyl-beta-boswellic acid |
3-O-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner wi...
|
| TN1374 |
alpha-Chaconine |
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
|
| TN1410 |
Asperulosidic acid |
Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors. |
| TN1581 |
Dihydroguaiaretic acid |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. |
| TN1660 |
Ganoderic acid C1 |
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic...
|
| TN1664 |
Ganoderic acid H |
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting ...
|
| TN1683 |
Gentisin |
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity. |
| TN1990 |
Norathyriol |
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. |
| TN2202 |
Sempervirine |
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA . |
| TN2298 |
Vincosamide |
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can...
|
| TN2507 |
1,6,7-Trihydroxyxanthone |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gr...
|
| TN2529 |
1-Decarboxy-3-oxo-ceanothic acid |
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in pa...
|
| TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
|
| TN3691 |
Communic acid |
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmeti...
|
| TN3802 |
Dehydrodiconiferyl alcohol |
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol ...
|
| TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
|
| TN3967 |
Epieriocalyxin A |
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future. |
| TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
|
| TN4227 |
Horminone |
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi...
|
| TN4394 |
Kobophenol A |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cel...
|
| TN4437 |
Licorisoflavan A |
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating...
|
| TN4913 |
Riddelline |
Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver. |
| TN4938 |
Samidin |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. |
| TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
|
| TN5153 |
Torilin |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...
|
| TP1430 |
DTP3 TFA (1809784-29-9 free base) |
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. |
| TQ0016 |
NKP-1339 |
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. |
