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DNA Damage/DNA Repair DNA/RNA Synthesis

DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat No. product name
T0095 Bendamustine hydrochloride Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T0148 Calcium folinate Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T0164 Oxaliplatin Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
T0189 Pemetrexed acid Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T0189L Pemetrexed disodium Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
T0251 GemcitabineHOT Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0297 Clofarabine Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 6...
T0353 Osalmid Osalmid is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
T0415 Guanidine hydrochloride Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0676 Hydroxyurea Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T0681 Rifampicin Rifampicin is an antibacterial drug of the class of rifamycin.
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0926 Azelaic acid Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
T0964 Floxuridine Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T0984 FluorouracilHOT Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
T0986 Fluorocytosine Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
T1038 FludarabineHOT Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T1055 Ifosfamide Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mu...
T1058 Carboplatin Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
T1086 Vitamin D2 Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder...
T1087 Valacyclovir hydrochloride Valacyclovir is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
T1120 Dacarbazine Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T1153 Trimethoprim Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
T1154 Rifaximin Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-s...
T11600 IBR2 IBR2 is a specific RAD51 inhibitor.
T1178 TemozolomideHOT Temozolomide is a DNA alkylating agent interfering with DNA replication.
T12006 Metarrestin Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts ...
T1233 Oxolinic acid Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
T12682 RAD51-IN-2 RAD51-IN-2 is a inhibitor of RAD51.
T1272 Cytarabine Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterica...
T1276 Danofloxacin mesylate Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
T1307 Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopa...
T13479 2-Keto-D-galactose 2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.
T1349 5-Fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to ...
T13584 BMVC-8C3O BMVC-8C3O is a DNA G-quadruplexe (G4) ligand, can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
T1378 Tegafur Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the...
T1408 Capecitabine Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively a...
T1417 Mechlorethamine hydrochloride Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
T1428 Trifluridine Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, ...
T1454 Aciclovir Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoste...
T1465 Mupirocin Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
T1488 Procarbazine hydrochloride Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cy...
T1501 Rifabutin Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
T1506 Vidarabine Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA...
T15094 Dehydroaltenusin Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits...
T1511 Daunorubicin hydrochloride Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T15235 Enocitabine Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegaloviru...
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T15611 JH-RE-06 JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor...
T1564 CisplatinHOT Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
T1591 Cyclocytidine hydrochloride Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydr...
T1600 Doxifluridine Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, design...
T1617 Enrofloxacin Enrofloxacin is a veterinary antibacterial agent, used in poultry.
T1629 Rifapentine Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
T1646 Famciclovir Famciclovir is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and D...
T1663 Deoxythymidine triphosphate Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
T1665 Daptomycin Daptomycin is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
T16749 Rifalazil Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polyme...
T1679 Thiostrepton Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastit...
T1703 SN38 SN-38 is an active metabolite of CPT-11.
T17071 Thiarabine Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
T1721 2'-Deoxyuridine 2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagno...
T1724 SCR7 pyrazine Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
T1767 BMH21 BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.
T1840 Isoindigotin Isoindigotin is used in the therapy of Y.
T1982 Triapine Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).
T19833 5-Fluoroorotic acid 5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-exp...
T20945 2,4-D 2,4-Dichlorophenoxyacetic acid is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ...
T2100 CX5461 CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA.
T2201 6-Mercaptopurine monohydrate 6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually i...
T2219 Puromycin dihydrochloride Puromycin hydrochloride is a cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and...
T22429 SR18662 SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cance...
T22443 Triglycidyl Isocyanurate Triglycidyl Isocyanurate, a triazene triepoxide with antineoplastic activity, could inhibit growth of human non-small cell lung cancer cells by activating p53. ...
T2275 YK-4-279 YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
T2276 RI1 RI-1 is a RAD51 inhibitor (IC50: 5-30 μM).
T2410 Nedaplatin Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate...
T2504 Pritelivir Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
T2627 Nolatrexed dihydrochloride Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatre...
T2628 RI2 RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in h...
T2708 SL327 SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
T2942 Psoralen Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
T3157 COH29 COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activit...
T3340 SCR7 SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T3343 5-methoxyflavone 5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.
T3400 Bakuchiol Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has ...
T3524 Halofuginone hydrobromide Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression o...
T3628 Madrasin Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.
T3658 TAS102 TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
T3772 Maslinic acid Maslinic acid is a DNA polymerase B inhibitor.
T4010 Juglone Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidy...
T4060 Acelarin Acelarin (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4226 Amenamevir Amenamevir is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL).
T4228 Nolatrexed Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
T4311 HAMNO HAMNO is a protein interaction inhibitor of replication protein A (RPA).
T4336 IPTG IPTG is a non-metabolizable galactose analog that induces expression of the LAC OPERON.
T4356 Compound 3A Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
T4382 Proguanil hydrochloride Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted...
T4457 Pyridostatin Trihydrochloride(free base 1085412-37-8 ) Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.
T4470 Pyridostatin TFA Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-k...
T4517 L189 L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
T4569 Lucanthone Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
T4641 LMI 070 LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
T4656 B02 RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
T4687 Ro 5-3335 Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/C...
T5413 ML216 ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (...
T5942 Docosanoic acid Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.
T6069 Gemcitabine HClHOT Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
T6116 Bleomycin Sulfate Bleomycin Sulfate, a glycopeptide antibiotic, is an anticancer agent for squamous cell carcinomas (SCC). In UT-SCC-19A cells, the IC50 of Bleomycin Sulfate is 4...
T6194 Fidaxomicin Fidaxomicin is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorpti...
T6225 Adenine hydrochloride Adenine HCl is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.
T6226 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is...
T6244 Cidofovir Cidofovir inhibits virus replication by specific inhibition of viral DNA synthesis.
T6369 Adenine sulfate Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
T6446 Clevudine Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolit...
T6456 CRT0044876 CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T6501 Fludarabine Phosphate Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic acti...
T6603 Nelarabine Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T6632 Raltitrexed Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
T6752 Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-infl...
T6753 AI-10-49 AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
T6823 E3330 E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T6856 Halofuginone Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in th...
T6894 ML264 ML264 is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.
T6908 NSC228155 NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T6974 Saccharin 1-methylimidazole (SMI) SMI is a general-purpose activator used for DNA and RNA synthesis.
T6S0139 Neobavaisoflavone 1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases....
T7004 Tubercidin Tubercidin, an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA ...
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T7429 Datelliptium chloride Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
T7525 Didox Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients...
T7655 Fialuridine Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro an...
T7747 Datelliptium chloride hydrochloride Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
T8647 BCH001 BCH001 is a specific small-molecule inhibitor of PAPD5.
T8785 HALOFUGINONE LACTATE HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone...
T8800 NSAH NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
T8886 NITD-2 NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DE...
TL0005 (-)-3,5-Dicaffeoyl quinic acid 3,5-Dicaffeoylquinic acid is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and...
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
TMA0984 Cerevisterol Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
TN1016 Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidativ...
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle ...
TN1258 3-O-Acetyl-beta-boswellic acid 3-O-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner wi...
TN1374 alpha-Chaconine Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
TN1410 Asperulosidic acid Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors.
TN1581 Dihydroguaiaretic acid Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
TN1660 Ganoderic acid C1 Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic...
TN1664 Ganoderic acid H Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting ...
TN1683 Gentisin Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
TN1990 Norathyriol Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
TN2202 Sempervirine Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
TN2298 Vincosamide Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can...
TN2507 1,6,7-Trihydroxyxanthone 1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gr...
TN2529 1-Decarboxy-3-oxo-ceanothic acid 1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in pa...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TN3691 Communic acid Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmeti...
TN3802 Dehydrodiconiferyl alcohol Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol ...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN3967 Epieriocalyxin A Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4227 Horminone Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi...
TN4394 Kobophenol A Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cel...
TN4437 Licorisoflavan A Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating...
TN4913 Riddelline Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
TN4938 Samidin Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...
TP1430 DTP3 TFA (1809784-29-9 free base) DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
TQ0016 NKP-1339 NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
Bendamustine hydrochloride
T0095CAS 3543-75-7
Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
Calcium folinate
T0148CAS 1492-18-8
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
Oxaliplatin
T0164CAS 61825-94-3
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
Pemetrexed acid
T0189CAS 137281-23-3
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
Pemetrexed disodium
T0189LCAS 150399-23-8
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
Gemcitabine HOT
T0251CAS 95058-81-4
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Clofarabine
T0297CAS 123318-82-1
Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 6...
Osalmid
T0353CAS 526-18-1
Osalmid is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
Guanidine hydrochloride
T0415CAS 50-01-1
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
Hydroxyurea
T0676CAS 127-07-1
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Rifampicin
T0681CAS 13292-46-1
Rifampicin is an antibacterial drug of the class of rifamycin.
Ribavirin
T0684CAS 36791-04-5
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Azelaic acid
T0926CAS 123-99-9
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
Floxuridine
T0964CAS 50-91-9
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Fluorouracil HOT
T0984CAS 51-21-8
Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
Fluorocytosine
T0986CAS 2022-85-7
Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
Fludarabine HOT
T1038CAS 21679-14-1
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Ifosfamide
T1055CAS 3778-73-2
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mu...
Carboplatin
T1058CAS 41575-94-4
Carboplatin is an organoplatinum compound that possesses antineoplastic activity.
Vitamin D2
T1086CAS 50-14-6
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder...
Valacyclovir hydrochloride
T1087CAS 124832-27-5
Valacyclovir is an acyclovir prodrug that inhibits viral DNA replication after metabolization.
Dacarbazine
T1120CAS 4342-03-4
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
Trimethoprim
T1153CAS 738-70-5
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
Rifaximin
T1154CAS 80621-81-4
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-s...
IBR2
T11600CAS 313526-24-8
IBR2 is a specific RAD51 inhibitor.
Temozolomide HOT
T1178CAS 85622-93-1
Temozolomide is a DNA alkylating agent interfering with DNA replication.
Metarrestin
T12006CAS 1443414-10-5
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts ...
Oxolinic acid
T1233CAS 14698-29-4
Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
RAD51-IN-2
T12682CAS 2301085-04-9
RAD51-IN-2 is a inhibitor of RAD51.
Cytarabine
T1272CAS 147-94-4
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterica...
Danofloxacin mesylate
T1276CAS 119478-55-6
Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
Carmofur
T1307CAS 61422-45-5
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopa...
2-Keto-D-galactose
T13479CAS 54142-77-7
2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.
5-Fluorouridine
T1349CAS 316-46-1
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to ...
BMVC-8C3O
T13584CAS 1301708-12-2
BMVC-8C3O is a DNA G-quadruplexe (G4) ligand, can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
Tegafur
T1378CAS 17902-23-7
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the...
Capecitabine
T1408CAS 154361-50-9
Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively a...
Mechlorethamine hydrochloride
T1417CAS 55-86-7
Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
Trifluridine
T1428CAS 70-00-8
Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, ...
Aciclovir
T1454CAS 59277-89-3
Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoste...
Mupirocin
T1465CAS 12650-69-0
Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
Procarbazine hydrochloride
T1488CAS 366-70-1
Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cy...
Rifabutin
T1501CAS 72559-06-9
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tr...
Vidarabine
T1506CAS 5536-17-4
Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA...
Dehydroaltenusin
T15094CAS 31186-13-7
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits...
Daunorubicin hydrochloride
T1511CAS 23541-50-6
Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
Enocitabine
T15235CAS 55726-47-1
Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegaloviru...
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
JH-RE-06
T15611CAS 1361227-90-8
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor...
Cisplatin HOT
T1564CAS 15663-27-1
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
Cyclocytidine hydrochloride
T1591CAS 10212-25-6
Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydr...
Doxifluridine
T1600CAS 3094-09-5
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, design...
Enrofloxacin
T1617CAS 93106-60-6
Enrofloxacin is a veterinary antibacterial agent, used in poultry.
Rifapentine
T1629CAS 61379-65-5
Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
Famciclovir
T1646CAS 104227-87-4
Famciclovir is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and D...
Deoxythymidine triphosphate
T1663CAS 18423-43-3
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
Daptomycin
T1665CAS 103060-53-3
Daptomycin is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
Rifalazil
T16749CAS 129791-92-0
Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polyme...
Thiostrepton
T1679CAS 1393-48-2
Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastit...
SN38
T1703CAS 86639-52-3
SN-38 is an active metabolite of CPT-11.
Thiarabine
T17071CAS 26599-17-7
Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
2'-Deoxyuridine
T1721CAS 951-78-0
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagno...
SCR7 pyrazine
T1724CAS 14892-97-8
Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
BMH21
T1767CAS 896705-16-1
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.
Isoindigotin
T1840CAS 476-34-6
Isoindigotin is used in the therapy of Y.
Triapine
T1982CAS 143621-35-6
Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).
5-Fluoroorotic acid
T19833CAS 703-95-7
5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-exp...
2,4-D
T20945CAS 94-75-7
2,4-Dichlorophenoxyacetic acid is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ...
CX5461
T2100CAS 1138549-36-6
CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA.
6-Mercaptopurine monohydrate
T2201CAS 6112-76-1
6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually i...
Puromycin dihydrochloride
T2219CAS 58-58-2
Puromycin hydrochloride is a cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and...
SR18662
T22429CAS T22429
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cance...
Triglycidyl Isocyanurate
T22443CAS 2451-62-9
Triglycidyl Isocyanurate, a triazene triepoxide with antineoplastic activity, could inhibit growth of human non-small cell lung cancer cells by activating p53. ...
YK-4-279
T2275CAS 1037184-44-3
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
RI1
T2276CAS 415713-60-9
RI-1 is a RAD51 inhibitor (IC50: 5-30 μM).
Nedaplatin
T2410CAS 95734-82-0
Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate...
Pritelivir
T2504CAS 348086-71-5
Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
Nolatrexed dihydrochloride
T2627CAS 152946-68-4
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatre...
RI2
T2628CAS 1417162-36-7
RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in h...
SL327
T2708CAS 305350-87-2
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
Psoralen
T2942CAS 66-97-7
Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.
COH29
T3157CAS 1190932-38-7
COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activit...
SCR7
T3340CAS 1533426-72-0
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
5-methoxyflavone
T3343CAS 42079-78-7
5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.
Bakuchiol
T3400CAS 10309-37-2
Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has ...
Halofuginone hydrobromide
T3524CAS 64924-67-0
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression o...
Madrasin
T3628CAS 374913-63-0
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.
TAS102
T3658CAS 733030-01-8
TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
Maslinic acid
T3772CAS 4373-41-5
Maslinic acid is a DNA polymerase B inhibitor.
Juglone
T4010CAS 481-39-0
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidy...
Acelarin
T4060CAS 840506-29-8
Acelarin (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
Gemcitabine monophosphate sodium salt hydrate
T4187CAS 1638288-31-9
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Amenamevir
T4226CAS 841301-32-4
Amenamevir is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL).
Nolatrexed
T4228CAS 147149-76-6
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
HAMNO
T4311CAS 138736-73-9
HAMNO is a protein interaction inhibitor of replication protein A (RPA).
IPTG
T4336CAS 367-93-1
IPTG is a non-metabolizable galactose analog that induces expression of the LAC OPERON.
Compound 3A
T4356CAS 1822358-25-7
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
Proguanil hydrochloride
T4382CAS 637-32-1
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted...
Pyridostatin Trihydrochloride(free base 1085412-37-8 )
T4457CAS T4457
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.
Pyridostatin TFA
T4470CAS 1472611-44-1
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-k...
L189
T4517CAS 64232-83-3
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
Lucanthone
T4569CAS 479-50-5
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
LMI 070
T4641CAS 1562338-42-4
LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
B02
T4656CAS 1290541-46-6
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
Ro 5-3335
T4687CAS 30195-30-3
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/C...
ML216
T5413CAS 1430213-30-1
ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (...
Docosanoic acid
T5942CAS 112-85-6
Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.
Gemcitabine HCl HOT
T6069CAS 122111-03-9
Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
Bleomycin Sulfate
T6116CAS 9041-93-4
Bleomycin Sulfate, a glycopeptide antibiotic, is an anticancer agent for squamous cell carcinomas (SCC). In UT-SCC-19A cells, the IC50 of Bleomycin Sulfate is 4...
Fidaxomicin
T6194CAS 873857-62-6
Fidaxomicin is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorpti...
Adenine hydrochloride
T6225CAS 2922-28-3
Adenine HCl is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.
Pemetrexed Disodium Hydrate
T6226CAS 357166-30-4
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is...
Cidofovir
T6244CAS 113852-37-2
Cidofovir inhibits virus replication by specific inhibition of viral DNA synthesis.
Adenine sulfate
T6369CAS 321-30-2
Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
Clevudine
T6446CAS 163252-36-6
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolit...
CRT0044876
T6456CAS 6960-45-8
CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
Fludarabine Phosphate
T6501CAS 75607-67-9
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic acti...
Nelarabine
T6603CAS 121032-29-9
Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
Raltitrexed
T6632CAS 112887-68-0
Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
Ademetionine disulfate tosylate
T6752CAS 97540-22-2
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-infl...
AI-10-49
T6753CAS 1256094-72-0
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
E3330
T6823CAS 136164-66-4
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
Halofuginone
T6856CAS 55837-20-2
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in th...
ML264
T6894CAS 1550008-55-3
ML264 is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.
NSC228155
T6908CAS 113104-25-9
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
Saccharin 1-methylimidazole (SMI)
T6974CAS 482333-74-4
SMI is a general-purpose activator used for DNA and RNA synthesis.
Neobavaisoflavone
T6S0139CAS 41060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases....
Tubercidin
T7004CAS 69-33-0
Tubercidin, an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA ...
Urolithin A
T7174CAS 1143-70-0
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Datelliptium chloride
T7429CAS 105118-14-7
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
Didox
T7525CAS 69839-83-4
Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients...
Fialuridine
T7655CAS 69123-98-4
Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro an...
Datelliptium chloride hydrochloride
T7747CAS 157000-76-5
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.
BCH001
T8647CAS 384859-58-9
BCH001 is a specific small-molecule inhibitor of PAPD5.
HALOFUGINONE LACTATE
T8785CAS 82186-71-8
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone...
NSAH
T8800CAS 1099592-35-4
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
NITD-2
T8886CAS 1197896-79-9
NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DE...
(-)-3,5-Dicaffeoyl quinic acid
TL0005CAS 89919-62-0
3,5-Dicaffeoylquinic acid is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and...
Dehydroglyasperin D
TMA0291CAS 517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
Cerevisterol
TMA0984CAS 516-37-0
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
Kukoamine A
TN1016CAS 75288-96-9
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidativ...
3'-Demethylnobiletin
TN1244CAS 112448-39-2
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle ...
3-O-Acetyl-beta-boswellic acid
TN1258CAS 5968-70-7
3-O-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner wi...
alpha-Chaconine
TN1374CAS 20562-03-2
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
Asperulosidic acid
TN1410CAS 25368-11-0
Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors.
Dihydroguaiaretic acid
TN1581CAS 66322-34-7
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
Ganoderic acid C1
TN1660CAS 95311-97-0
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic...
Ganoderic acid H
TN1664CAS 98665-19-1
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting ...
Gentisin
TN1683CAS 437-50-3
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
Norathyriol
TN1990CAS 3542-72-1
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Sempervirine
TN2202CAS 6882-99-1
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
Vincosamide
TN2298CAS 23141-27-7
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can...
1,6,7-Trihydroxyxanthone
TN2507CAS 25577-04-2
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gr...
1-Decarboxy-3-oxo-ceanothic acid
TN2529CAS 214150-74-0
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in pa...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
Communic acid
TN3691CAS 2761-77-5
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmeti...
Dehydrodiconiferyl alcohol
TN3802CAS 4263-87-0
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol ...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
Epieriocalyxin A
TN3967CAS 191545-24-1
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
Horminone
TN4227CAS 21887-01-4
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi...
Kobophenol A
TN4394CAS 124027-58-3
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cel...
Licorisoflavan A
TN4437CAS 129314-37-0
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating...
Riddelline
TN4913CAS 23246-96-0
Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
Samidin
TN4938CAS 477-33-8
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...
DTP3 TFA (1809784-29-9 free base)
TP1430CAS TP1430
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
NKP-1339
TQ0016CAS 197723-00-5
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.