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Signaling pathway Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones Enzyme GPCR/G Protein Immunology / Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology&virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling
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DNA Damage/DNA Repair DNA gyrase

DNA gyrase

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.
Cat No. product name
T0116 Balofloxacin Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
T0250 Ciprofloxacin hydrochloride Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T0717 Enoxacin Sesquihydrate Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T0974 Albamycinsodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
T1095 Sparfloxacin Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T1294 Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T1306 Norfloxacin Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T1451 Levofloxacin Hemihydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
T1492 Gemifloxacin mesylate Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin M...
T2353 BRD7716 BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity.
TQ0063 Zoliflodacin Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-posi...
T7786 Tryptanthrin Tryptanthrin is a natural DNA gyrase inhibitor。
T13231 Trovafloxacin Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Balofloxacin
T0116CAS 127294-70-6
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
Ciprofloxacin hydrochloride
T0250CAS 93107-08-5
Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Enoxacin Sesquihydrate
T0717CAS 84294-96-2
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
Albamycinsodium
T0974CAS 1476-53-5
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
Sparfloxacin
T1095CAS 110871-86-8
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
Fleroxacin
T1294CAS 79660-72-3
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
Norfloxacin
T1306CAS 70458-96-7
Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Levofloxacin Hemihydrate
T1451CAS 138199-71-0
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
Gemifloxacin mesylate
T1492CAS 210353-53-0
Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin M...
BRD7716
T2353CAS 329059-55-4
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity.
Zoliflodacin
TQ0063CAS 1620458-09-4
Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-posi...
Tryptanthrin
T7786CAS 13220-57-0
Tryptanthrin is a natural DNA gyrase inhibitor。
Trovafloxacin
T13231CAS 147059-72-1
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
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