DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.

Cat. No.	Product name	CAS No.	Purity
T2377	Pilaralisib analogue	956958-53-5	99.46%
T2377	Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T4339	YU238259	1943733-16-1	99.43%
T4339	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T3351	Onatasertib	1228013-30-6	99.41%
T3351	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
T6045	Torin 1	1222998-36-8	99.38%
T6045	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T7014	Voxtalisib	934493-76-2	99.36%
T7014	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
T9760	IC 86621	404009-40-1	99.33%
T9760	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitu...
T9498	BAY-8400	T9498	99.32%
T9498	BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combinat...
T6143	PI-103	371935-74-9	99.3%
T6143	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
T6557	KU-0060648	881375-00-4	99.21%
T6557	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of...
T25399	ETP-45658	1198357-79-7	99.13%
T25399	ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DN...
T3986	SF2523	1174428-47-7	98.06%
T3986	SF2523 is a highly selective and potent inhibitor.
T2287	PIK-75 hydrochloride	372196-77-5	98%
T2287	PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also pote...
T2461	PIK-90	677338-12-4	98%
T2461	PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
T2083	PI-3065	955977-50-1	98%
T2083	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T6319	OSI-027	936890-98-1	98%
T6319	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
T7122	AZD-7648	2230820-11-6	98%
T7122	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
T11067	VX-984	1476074-39-1	97.65%
T11067	VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ an...
T13017	STL127705	1326852-06-5	97.41%
T13017	STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activa...
T1826	PI3K-IN-1	1349796-36-6	97.07%
T1826	PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T3541	CC-115	1228013-15-7	86.79%
T3541	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).