DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T79233	RdRP-IN-6		98%
T79233	RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM. It has potential applications in antiviral a...
T79290	SRE-II		98%
T79290	SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence and photosens...
T79307	DNA polymerase-IN-2		98%
T79307	DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holds pot...
T79308	DNA polymerase-IN-3	381689-75-4	98%
T79308	DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in proliferativ...
T79334	Antiviral agent 36		98%
T79334	Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100 n...
T79488	RNase L-IN-1		98%
T79488	RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication, and pl...
T79682	Qsl-304		98%
T79682	QSL-304 is a DNA gyrase B inhibitor that serves as an antibacterial agent, exhibiting an IC50 of 31.23 mg/mL against Staphylococcus aureus SA-P2003 [1].
T79763	UNC9512		98%
T79763	UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editing,...
T79865	Votoplam	2407849-89-0	98%
T79865	Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].
T79921	Moloney murine leukemia virus RT		98%
T79921	Moloney murine leukemia virus reverse transcriptase (MMLV RT) is a monomeric replicative polymerase intrinsic to the retrovirus life cycle [1].
T79922	Taq DNA polymerase	2304873-37-6	98%
T79922	Taq DNA polymerase is a thermostable enzyme utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].
T79923	T7 RNA polymerase	9014-24-8	98%
T79923	T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (...
T79924	T4 RNA ligase		98%
T79924	T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA. It is utilized for the synthesis of enzymatic oligoribonucleotides and the 3′-te...
T79925	T4 UvsX Recombinase		98%
T79925	T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand. It significantly enhanc...
T79926	Poly(A) polymerase	9026-30-6	98%
T79926	Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP. This mod...
T80207	Tetrapeptide	31008-44-3	98%
T80207	Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNA p...
T80655	BVDU 5′-Triphosphate	77222-61-8	98%
T80655	BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase. It exhibits outstanding selectivity for v...
T82614	DAM-IN-1	935279-95-1	98%
T82614	DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM. It effectively inhibits Caulobacter growth, exhibiting a minimum inhibit...
T82803	Butylparaben sodium	36457-20-2	98%
T82803	Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1]...
TN4038	Eupatolide	6750-25-0	98%
TN4038	Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...