DUB

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.

Cat. No.	Product name	CAS No.	Purity
T11485	GSK2643943A	2449301-27-1	98.06%
T11485	GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
T60146	USP8-IN-1	2477650-96-5	98.01%
T60146	USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].
T3088	N-Ethylmaleimide	128-53-0	98%
T3088	N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T6107	IU1	314245-33-5	98%
T6107	IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
T1902	BAY 11-7082	19542-67-7	97.91%
T1902	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-s...
T1924	LDN-57444	668467-91-2	97.8%
T1924	LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
T14852	C527	192718-06-2	97.64%
T14852	C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
T6697	TCID	30675-13-9	97.16%
T6697	TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T13267	USP30 inhibitor 11	2067332-64-1	96.31%
T13267	USP30 inhibitor 11 (USP30-IN-11) is a selective USP30 inhibitor (IC50: 0.01 µΜ) that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction...
T1932	B-AP15	1009817-63-3	95.07%
T1932	B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating ac...
T15729	LDN-91946	439946-22-2	92.78%
T15729	LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
T28284	P22074	90680-28-7	100%
T28284	P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.
T15351	FT827	1959537-86-0	98%
T15351	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apoli...
T11112	DUB-IN-3	924296-17-3	98%
T11112	DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.
T1937	Spautin-1	1262888-28-7	98%
T1937	Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induc...
T11110	DUB-IN-1	924296-18-4	98%
T11110	DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T7678	SJB2-043	63388-44-3	98%
T7678	SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
T12024	MF-094	2241025-68-1	98%
T12024	MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).
T73560	I-138	2098211-50-6	98%
T73560	I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in ce...
T74794	USP28-IN-4	2931509-15-6	98%
T74794	USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x,...