T17224 |
VER-246608
|
1684386-71-7
|
98.88%
|
|
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
|
T2057 |
BVT 2733
|
376640-41-4
|
98.84%
|
|
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
|
T2121 |
SW033291
|
459147-39-8
|
98.78%
|
|
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
|
T2650 |
MK-8245
|
1030612-90-8
|
98.77%
|
|
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
|
T64347 |
ALDH1A3-IN-3
|
18962-05-5
|
98.74%
|
|
ALDH1A3-IN-3 (compound 16), a powerful ALDH1A3 inhibitor with an IC50 of 0.26 μM, serves as an effective ALDH3A1 substrate. It is utilized in prostate cancer res...
|
T11029 |
HDHODH-IN-5
|
2029049-77-0
|
98.70%
|
|
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
|
T2447 |
AZD7545
|
252017-04-2
|
98.69%
|
|
AZD7545 is a potent PDHK inhibitor.
|
T8640 |
G6PDi-1
|
2457232-14-1
|
98.69%
|
|
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
|
T9394 |
CHIKV-IN-2
|
2361289-44-1
|
98.67%
|
|
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis af...
|
T11027 |
DHODH-IN-4
|
1148125-93-2
|
98.65%
|
|
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, resp...
|
T9594 |
BI-187004
|
1303515-32-3
|
98.63%
|
|
BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
|
T16510 |
PF-915275
|
857290-04-1
|
98.62%
|
|
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF...
|
T77579 |
JC2-11
|
937820-89-8
|
98.6%
|
|
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
|
T0245 |
RS 61443
|
115007-34-6
|
98.58%
|
|
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
|
T13100 |
TC HSD 21
|
330203-01-5
|
98.5%
|
|
TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).
|
T11765 |
KPLH1130
|
906669-07-6
|
98.43%
|
|
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macropha...
|
T23533 |
WIN 18446
|
1477-57-2
|
98.41%
|
|
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
|
T5S0620 |
3-Dehydrotrametenolic acid
|
29220-16-4
|
98.39%
|
|
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new...
|
T3175 |
LDHA-IN-4
|
1370290-34-8
|
98.17%
|
|
LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells b...
|
T3604 |
Sodium dichloroacetate
|
2156-56-1
|
98.17%
|
|
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has ...
|