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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11021 DHODH-IN-12 1263303-93-0 100%
DHODH-IN-12
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
T10140 4-Diethylaminobenzaldehyde 120-21-8
4-Diethylaminobenzaldehyde
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μ...
T19831 Sodium Oxamate 565-73-1 98%
Sodium Oxamate
Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor. Sodium oxamate induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and ...
T4173 R162 64302-87-0 98%
R162
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
T2901 Daidzin 552-66-9 98%
Daidzin
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T73143 PHGDH-IN-3 2893778-31-7 98%
PHGDH-IN-3
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about can...
T73446 BI‑3231 2894848-07-6 98%
BI‑3231
BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study...
T9494 Imidazole-5-propionic acid 1074-59-5 98%
Imidazole-5-propionic acid
Imidazole-5-propionic acid (Imidazolylpropionic acid) is a product of histidine metabolism and may involve oxidation or transamination. Imidazole-5-propionic aci...
T0494 Tetramisole hydrochloride 5086-74-8 98%
Tetramisole hydrochloride
Tetramisole hydrochloride (Tetramisole HCl) inhibits alkaline phosphatase and is a high-purity antiparasitic agent.
T2650 MK-8245 1030612-90-8 98%
MK-8245
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T77576 17β-HSD10-IN-1 2316765-78-1 98%
17β-HSD10-IN-1
17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of A...
T12196 NCT-505 2231079-74-4 98%
NCT-505
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC...
T10146 4-Hydroxyderricin 55912-03-3 98%
4-Hydroxyderricin
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
T12438 PfDHODH-IN-1 183945-55-3 98%
PfDHODH-IN-1
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.
T0897 Nitrofurazone 59-87-0 98%
Nitrofurazone
Nitrofurazone (Furacilin) is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJ...
T0647 Tryptamine 61-54-1 98%
Tryptamine
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
T1809 AGI-6780 1432660-47-3 98%
AGI-6780
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T6157 Devimistat 95809-78-2 98%
Devimistat
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, ...
T40686 Tiazofurin 60084-10-8 98%
Tiazofurin
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenin...
T37190 L-Allylglycine 16338-48-0 98%
L-Allylglycine
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
DHODH-IN-12
T11021
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
4-Diethylaminobenzaldehyde
T10140
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μ...
Sodium Oxamate
T19831
Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor. Sodium oxamate induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and ...
R162
T4173
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
Daidzin
T2901
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
PHGDH-IN-3
T73143
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about can...
BI‑3231
T73446
BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study...
Imidazole-5-propionic acid
T9494
Imidazole-5-propionic acid (Imidazolylpropionic acid) is a product of histidine metabolism and may involve oxidation or transamination. Imidazole-5-propionic aci...
Tetramisole hydrochloride
T0494
Tetramisole hydrochloride (Tetramisole HCl) inhibits alkaline phosphatase and is a high-purity antiparasitic agent.
MK-8245
T2650
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
17β-HSD10-IN-1
T77576
17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of A...
NCT-505
T12196
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC...
4-Hydroxyderricin
T10146
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
PfDHODH-IN-1
T12438
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.
Nitrofurazone
T0897
Nitrofurazone (Furacilin) is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJ...
Tryptamine
T0647
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
AGI-6780
T1809
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
Devimistat
T6157
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, ...
Tiazofurin
T40686
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenin...
L-Allylglycine
T37190
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
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TargetMol