deubiquitinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11111	DUB-IN-2		DUB
	Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.		DUB
T11110	DUB-IN-1		DUB
	DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).		DUB
T4067	VLX1570		DUB
	VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.		DUB
T14852	C527		DUB
	C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).		DUB
T11112	DUB-IN-3		DUB
	DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.		DUB
T9122	XL177A		DUB
	XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.		DUB
T3555	ML364		DUB
	ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.		DUB
T15604	IU1-47		DUB
	IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).		DUB
T15464	HBX 19818		DUB
	HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).		DUB
T12024	MF-094		DUB
	MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).		DUB
T36682	USP30 inhibitor 18		DUB
	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...		DUB
T11209	EOAI3402143		DUB
	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.		DUB
T9375	IU1-248		DUB
	IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].		DUB
T5461	GNE-6640		DUB
	GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23...		DUB
T15729	LDN-91946		DUB
	LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).		DUB
T1924	LDN-57444	LDN57444	Apoptosis , DUB
	LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .		Apoptosis , DUB
T13268	USP7-IN-1		DUB
	USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).		DUB
T2424	P 22077	P22077	DUB
	P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.		DUB
T1757	ML-323	ML323	DUB
	ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I...		DUB
T6107	IU1		DUB , Autophagy
	IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.		DUB , Autophagy
T9884	EN523		Others
	EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.		Others
T11464	GRL0617		SARS-CoV , DUB
	GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).		SARS-CoV , DUB
T8553	BC-1471		Others
	BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1].		Others
T6300	Degrasyn	WP1130	Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
	Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri...		Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
T4634	GNE-6776	GEN6776	DUB
	GNE-6776 is a selective USP7 inhibitor.		DUB
T9217	USP7-IN-8	GNE-6776	DUB
	Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 (GNE-6776) has anticancer effects.		DUB
T8464	RA-9		Apoptosis , DUB
	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.		Apoptosis , DUB
T7678	SJB2-043		DUB
	SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).		DUB
T4338	USP7/USP47 inhibitor	USP7/47 inhibitor-1	DUB
	USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.		DUB
T6925	P005091	P5091	DUB
	P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.		DUB
T1932	B-AP15	NSC 687852	Apoptosis , DUB
	B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome.		Apoptosis , DUB
T6697	TCID	UCH-L3 Inhibitor	DUB
	TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.		DUB
T7685	USP25/28 inhibitor AZ1	AZ1	DUB
	USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28		DUB
T21527	HBX 41108	HBX-41108	DUB , p53
	HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.		DUB , p53
T3951	NSC632839	F6,Ubiquitin Isopeptidase Inhibitor II	DUB
	NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).		DUB
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T1902	BAY 11-7082	BAY 11-7821	Apoptosis , Others , IκB/IKK , DUB , Autophagy
	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).		Apoptosis , Others , IκB/IKK , DUB , Autophagy
T3088	N-Ethylmaleimide	1-Ethyl-1H-pyrrole-2,5-dione,Ethylmaleimide,NEM	Cysteine Protease , DUB
	N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.		Cysteine Protease , DUB
T3089	6-Thioguanine	6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine	Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy
	6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T8706	STAMBP-IN-1		Others
	STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.		Others
T60130	USP5-IN-1		DUB
	USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibi...		DUB
T70082	Pyrithione cadmium
	Pyrithione cadmium suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase
T75182	GK13S
	G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells [1] .
T36970	STD1T		DUB
	STD1T is a selective and potent inhibitor of the deubiquitinase USP2a with potential anticancer activity that reduces cell cycle protein D1 protein levels in HCT116 colon and MCF-7 breast cancer cells.		DUB
T74277	NJH-2-056
	NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research [1] .
T74276	LEB-03-153
	LEB-03-153 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker [1] .
T74274	LEB-03-145
	LEB-03-145 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker [1] .
T74371	LEB-03-146
	LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B ...
T71837	HBX
	HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also ...
T74275	LEB-03-144
	LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cance...

Compounds

DUB-IN-2

T11111

Target: Apoptosis, DUB

Target: DUB, Autophagy

Target: SARS-CoV, DUB

Target: Apoptosis, JAK, Bcr-Abl, DUB, Autophagy

Target: Apoptosis, DUB

Synonym: USP7/47 inhibitor-1

Target: Apoptosis, DUB

TCID

T6697

Synonym: UCH-L3 Inhibitor

Target: DUB

USP25/28 inhibitor AZ1

Synonym: F6,Ubiquitin Isopeptidase Inhibitor II

Target: DUB

PR-619

T1862

Synonym: PR 619,2,6-Diamino-3,5-dithiocyanopyridine

Target: Apoptosis, DUB, Autophagy

BAY 11-7082

T1902

Synonym: BAY 11-7821

Target: Apoptosis, Others, IκB/IKK, DUB, Autophagy

N-Ethylmaleimide

T3088

Synonym: 1-Ethyl-1H-pyrrole-2,5-dione,Ethylmaleimide,NEM

Target: Cysteine Protease, DUB

6-Thioguanine

T3089

Synonym: 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine

Target: Apoptosis, DNA Methyltransferase, SARS-CoV, Endogenous Metabolite, DUB, Autophagy

Cat No.	Product Name	Species	Expression System
TMPY-02214	OTUB1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...
TMPY-02522	OTUB2 Protein, Human, Recombinant (His)	Human	E. coli
	Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPH-02285	USP6 Protein, Human, Recombinant (His & KSI)	Human	E. coli
	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activit...
TMPH-02640	ZC3H12A Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...

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