Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No.	Product name	CAS No.	Purity
T67905	GS-829845	1257705-09-1	99.78%
T67905	GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life t...
T20723	LGE-899	1221722-10-6	99.77%
T20723	LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than...
T0150	Hydroxyhexamide	3168-01-2	99.75%
T0150	Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.
TN1742	Homovanillyl alcohol	2380-78-1	99.74%
TN1742	Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
T0249	N-Acetylprocainamide	32795-44-1	99.74%
T0249	N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic dr...
T1327	Nortriptyline hydrochloride	894-71-3	99.71%
T1327	Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major...
T13621	CNDAC hydrochloride	134665-72-8	99.69%
T13621	CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
Fr13756	Isonicotinic acid	55-22-1	99.68%
Fr13756	Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinoly...
T36061	N-Desmethyl Sildenafil	139755-82-1	99.68%
T36061	N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).
T0061	Clofibric acid	882-09-7	99.68%
T0061	Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T4281	Endoxifen	110025-28-0	99.66%
T4281	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It ...
T7174	Urolithin A	1143-70-0	99.66%
T7174	Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T67291	2′,2′-Difluorodeoxyuridine	114248-23-6	99.66%
T67291	2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine.2′,2′-Difluorodeoxyuridine has anticancer and antitumor activity, and shows radiosensiti...
T4494	CLOZAPINE N-OXIDE	34233-69-7	99.66%
T4494	Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD ...
T16339	Norverapamil hydrochloride	67812-42-4	99.63%
T16339	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel...
T8547	DCBA	72236-23-8	99.61%
T8547	DCBA, an endogenous metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), is utilized to evaluate DEET exposure through its concentration levels ...
T10147	4-Hydroxymephenytoin	61837-65-8	99.58%
T10147	4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.
T5420	Cycloguanil hydrochloride	152-53-4	99.46%
T5420	Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reduc...
T8945L	AST5902 mesylate(2412155-74-7 free base)	2412155-75-8	99.46%
T8945L	AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.
T13808	P-Coumaric Acid Ethyl Ester	7362-39-2	99.37%
T13808	p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a poten...