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Cat No. | Product Name | Synonyms | Targets |
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T24136 | Heclin | E1/E2/E3 Enzyme | |
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively. | |||
T12261 | NSC232003 | E1/E2/E3 Enzyme | |
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1. | |||
T16901 | SMIP004 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells. | |||
T7415 | DKM 2-93 | E1/E2/E3 Enzyme | |
DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM). | |||
T2158 | Nutlin-3 | Nutlin3 | E1/E2/E3 Enzyme |
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells. | |||
T3517 | RO8994 | Mdm2 , E1/E2/E3 Enzyme , p53 | |
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays). | |||
T5374 | NAcM-OPT | E1/E2/E3 Enzyme , NEDD8 | |
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM). | |||
T16102 | ML-792 | E1/E2/E3 Enzyme | |
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi... | |||
T16699 | PYZD-4409 | Others , E1/E2/E3 Enzyme | |
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells. | |||
T5199 | COH000 | E1/E2/E3 Enzyme | |
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro). | |||
T16888 | SJ-172550 | Mdm2 , E1/E2/E3 Enzyme | |
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM). | |||
T8428 | Subasumstat | TAK-981 | E1/E2/E3 Enzyme |
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities. | |||
T3653 | MX69 | Mdm2 , E1/E2/E3 Enzyme , IAP | |
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. | |||
T6149 | YH239-EE | Apoptosis , E1/E2/E3 Enzyme | |
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. | |||
T13244 | Ubiquitination-IN-1 | Others | |
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM). | |||
T6629 | PYR-41 | PYR41,PYR 41 | Apoptosis , E1/E2/E3 Enzyme |
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. | |||
T7379 | 2-D08 | E1/E2/E3 Enzyme , TAM Receptor | |
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect. | |||
T13349 | WS-383 | E1/E2/E3 Enzyme | |
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM). | |||
T10703 | Mezigdomide | CC-92480 | Apoptosis , E1/E2/E3 Enzyme , Molecular Glues |
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity. | |||
T9236 | WSB1 Degrader 1 | Others , E1/E2/E3 Enzyme | |
WSB1 Degrader 1 is a poten and orally active WD repeat and SOCS box-containing 1 degrader. WSB1 Degrader 1 has anticancer metastatic effects | |||
T3317 | SZL P1-41 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate... | |||
T11980 | MD-224 | Mdm2 , E1/E2/E3 Enzyme , PROTACs | |
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. | |||
T7889 | C25-140 | Others , TNF , E1/E2/E3 Enzyme , NF-κB | |
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13. | |||
T4253 | Skp2 Inhibitor C1 | SKPin C1 | Others , E1/E2/E3 Enzyme |
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. | |||
T23371 | SMER3 | SMER 3 | Others , Ligand for E3 Ligase |
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon... | |||
T8564 | BC-1382 | Others , E1/E2/E3 Enzyme | |
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM). | |||
T3549 | Avadomide | CC 122 | Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase |
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity. | |||
T6254 | Idasanutlin | RG7388,Ro 5503781 | Mdm2 , E1/E2/E3 Enzyme |
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM). | |||
T3110 | PRT4165 | NSC600157,PRT 4165 | BMI-1 , Others , E1/E2/E3 Enzyme |
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor. | |||
T6965 | RG7112 | RG-7112,RG 7112,RO5045337 | Mdm2 , E1/E2/E3 Enzyme |
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor. | |||
T5555 | Siremadlin | NVP-HDM 201 | E1/E2/E3 Enzyme |
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. | |||
T16974 | TAK-243 | MLN7243 | Apoptosis , E1/E2/E3 Enzyme , NF-κB |
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh... | |||
TQ0231 | NVP-CGM097 | CGM097 | Mdm2 , E1/E2/E3 Enzyme |
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2). | |||
TQ0127 | Navtemadlin | AMG232,CS-1300 | Mdm2 , E1/E2/E3 Enzyme |
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. | |||
T1493 | BH3I-1 | BHI1 | BCL , E1/E2/E3 Enzyme |
BH3I-1 (BHI1) is a Bcl-2 antagonist. | |||
T2243 | Serdemetan | JNJ-26854165 | Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53 |
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. | |||
T6611 | NSC697923 | 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran | E1/E2/E3 Enzyme |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me... | |||
T6023 | Nutlin-3a | (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 | Apoptosis , E1/E2/E3 Enzyme , Autophagy |
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein. | |||
T6585 | SAR405838 | MI773,MI 773,MI-77301,MI-773 | Mdm2 , E1/E2/E3 Enzyme |
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. | |||
T25465 | GS143 | GS-143,GS 143 | IκB/IKK , E1/E2/E3 Enzyme , NF-κB |
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... | |||
T8929 | BC1618 | 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- | Mitophagy , Others , E1/E2/E3 Enzyme , AMPK |
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophag... | |||
T6614 | Nutlin-3b | (+)-Nutlin-3 | Mdm2 , E1/E2/E3 Enzyme |
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4S0181 | Hinokiflavone | MMP , BCL , E1/E2/E3 Enzyme | |
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO... | |||
T9352 | Hydrocotarnine | Others | |
hydrocotarnine is an inhibitor of Cbl. | |||
T4036 | Solasodine | Solancarpidine,Purapuridine,Solasodin | Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal |
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma... | |||
T2947 | Indole-3-carbinol | I3C,3-Indolemethanol,Indole-3-Methanol | E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53 |
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation. | |||
T6S2123 | Ginkgolic Acid | Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1 | Others , E1/E2/E3 Enzyme |
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC. |
Cat No. | Product Name | Species | Expression System |
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TMPJ-00999 | UBE2D1 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes... | |||
TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli |
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain.... | |||
TMPJ-00486 | SUMO2 Protein, Human, Recombinant (His) | Human | E. coli |
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p... | |||
TMPY-02609 | UBE2M Protein, Human, Recombinant | Human | E. coli |
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02607 | Ube2H Protein, Human, Recombinant | Human | E. coli |
UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02608 | UBC9/UBE2I Protein, Human, Recombinant | Human | E. coli |
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02605 | UBE2F Protein, Human, Recombinant (His) | Human | E. coli |
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02604 | UBE2D4 Protein, Human, Recombinant (His) | Human | E. coli |
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed... | |||
TMPY-02606 | UBE2G1 Protein, Human, Recombinant | Human | E. coli |
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed... |
Cat No. | Product Name | ||
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L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |