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Ubiquitination E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

Cat No. product name
T6332 Pevonedistat MLN4924 is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
T6629 PYR-41 PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
T1902 BAY 11-7082 BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T5199 COH000 COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
T13090 TAS4464 hydrochloride TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
T16130 Mps1-IN-3 Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
T13090L TAS4464 TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
T8428 TAK-981 TAK-981 is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
T10703 CC-92480 CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.
Pevonedistat
T6332CAS 905579-51-3
MLN4924 is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
PYR-41
T6629CAS 418805-02-4
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
BAY 11-7082
T1902CAS 19542-67-7
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
COH000
T5199CAS 1534358-79-6
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
TAS4464 hydrochloride
T13090CAS 1848959-11-4
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
Mps1-IN-3
T16130CAS 1609584-72-6
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
TAS4464
T13090LCAS 1848959-10-3
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
TAK-981
T8428CAS 1858276-04-6
TAK-981 is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
CC-92480
T10703CAS 2259648-80-9
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.