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Search Results for " e2-conjugating "

Targets

44

Compounds

5

Natural Products

43

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T24136 Heclin E1/E2/E3 Enzyme
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
T12261 NSC232003 E1/E2/E3 Enzyme
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
T16901 SMIP004 Apoptosis , Others , E1/E2/E3 Enzyme
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
T7415 DKM 2-93 E1/E2/E3 Enzyme
DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
T16102 ML-792 E1/E2/E3 Enzyme
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...
T16699 PYZD-4409 Others , E1/E2/E3 Enzyme
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
T5199 COH000 E1/E2/E3 Enzyme
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
T2158 Nutlin-3 Nutlin3 E1/E2/E3 Enzyme
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
T3517 RO8994 Mdm2 , E1/E2/E3 Enzyme , p53
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
T5374 NAcM-OPT E1/E2/E3 Enzyme , NEDD8
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
T16888 SJ-172550 Mdm2 , E1/E2/E3 Enzyme
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T8428 Subasumstat TAK-981 E1/E2/E3 Enzyme
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
T3653 MX69 Mdm2 , E1/E2/E3 Enzyme , IAP
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6149 YH239-EE Apoptosis , E1/E2/E3 Enzyme
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T13244 Ubiquitination-IN-1 Others
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).
T6629 PYR-41 PYR41,PYR 41 Apoptosis , E1/E2/E3 Enzyme
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
T7379 2-D08 E1/E2/E3 Enzyme , TAM Receptor
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T9236 WSB1 Degrader 1 Others , E1/E2/E3 Enzyme
WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.
T13349 WS-383 E1/E2/E3 Enzyme
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T10703 Mezigdomide CC-92480 Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
T3317 SZL P1-41 Apoptosis , Others , E1/E2/E3 Enzyme
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...
T11980 MD-224 Mdm2 , E1/E2/E3 Enzyme , PROTACs
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
T7889 C25-140 Others , TNF , E1/E2/E3 Enzyme , NF-κB
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T4253 Skp2 Inhibitor C1 SKPin C1 Others , E1/E2/E3 Enzyme
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
T23371 SMER3 SMER 3 Others , Ligand for E3 Ligase
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...
T8564 BC-1382 Others , E1/E2/E3 Enzyme
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
T3549 Avadomide CC 122 Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T3110 PRT4165 NSC600157,PRT 4165 BMI-1 , Others , E1/E2/E3 Enzyme
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T6254 Idasanutlin RG7388,Ro 5503781 Mdm2 , E1/E2/E3 Enzyme
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T5555 Siremadlin NVP-HDM 201 E1/E2/E3 Enzyme
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
T6965 RG7112 RG-7112,RG 7112,RO5045337 Mdm2 , E1/E2/E3 Enzyme
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
T16974 TAK-243 MLN7243 Apoptosis , E1/E2/E3 Enzyme , NF-κB
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...
TQ0231 NVP-CGM097 CGM097 Mdm2 , E1/E2/E3 Enzyme
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
TQ0127 Navtemadlin AMG232,CS-1300 Mdm2 , E1/E2/E3 Enzyme
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T1493 BH3I-1 BHI1 BCL , E1/E2/E3 Enzyme
BH3I-1 (BHI1) is a Bcl-2 antagonist.
T2243 Serdemetan JNJ-26854165 Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T6611 NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran E1/E2/E3 Enzyme
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...
T6023 Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 Apoptosis , E1/E2/E3 Enzyme , Autophagy
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T6585 SAR405838 MI773,MI 773,MI-77301,MI-773 Mdm2 , E1/E2/E3 Enzyme
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T8929 BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophag...
T6614 Nutlin-3b (+)-Nutlin-3 Mdm2 , E1/E2/E3 Enzyme
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
T9140 NAcM-OPT HCl(2089293-61-6 free base) NEDD8
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
T13242 UbcH5c-IN-1 Others
UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85).

Compounds

Heclin
T24136
Synonym:
Target: E1/E2/E3 Enzyme
NSC232003
T12261
Synonym:
Target: E1/E2/E3 Enzyme
SMIP004
T16901
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
DKM 2-93
T7415
Synonym:
Target: E1/E2/E3 Enzyme
ML-792
T16102
Synonym:
Target: E1/E2/E3 Enzyme
PYZD-4409
T16699
Synonym:
Target: Others, E1/E2/E3 Enzyme
COH000
T5199
Synonym:
Target: E1/E2/E3 Enzyme
Nutlin-3
T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
RO8994
T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
NAcM-OPT
T5374
Synonym:
Target: E1/E2/E3 Enzyme, NEDD8
SJ-172550
T16888
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme
Subasumstat
T8428
Synonym: TAK-981
Target: E1/E2/E3 Enzyme
MX69
T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
YH239-EE
T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
Ubiquitination-IN-1
T13244
Synonym:
Target: Others
PYR-41
T6629
Synonym: PYR41,PYR 41
Target: Apoptosis, E1/E2/E3 Enzyme
2-D08
T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
WSB1 Degrader 1
T9236
Synonym:
Target: Others, E1/E2/E3 Enzyme
WS-383
T13349
Synonym:
Target: E1/E2/E3 Enzyme
Mezigdomide
T10703
Synonym: CC-92480
Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues
SZL P1-41
T3317
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
MD-224
T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
C25-140
T7889
Synonym:
Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB
Skp2 Inhibitor C1
T4253
Synonym: SKPin C1
Target: Others, E1/E2/E3 Enzyme
SMER3
T23371
Synonym: SMER 3
Target: Others, Ligand for E3 Ligase
BC-1382
T8564
Synonym:
Target: Others, E1/E2/E3 Enzyme
Avadomide
T3549
Synonym: CC 122
Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase
PRT4165
T3110
Synonym: NSC600157,PRT 4165
Target: BMI-1, Others, E1/E2/E3 Enzyme
Idasanutlin
T6254
Synonym: RG7388,Ro 5503781
Target: Mdm2, E1/E2/E3 Enzyme
Siremadlin
T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
RG7112
T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
TAK-243
T16974
Synonym: MLN7243
Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB
NVP-CGM097
TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
Navtemadlin
TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
BH3I-1
T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
Serdemetan
T2243
Synonym: JNJ-26854165
Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53
NSC697923
T6611
Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Target: E1/E2/E3 Enzyme
Nutlin-3a
T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
SAR405838
T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
GS143
T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
BC1618
T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Nutlin-3b
T6614
Synonym: (+)-Nutlin-3
Target: Mdm2, E1/E2/E3 Enzyme
NAcM-OPT HCl(2089293-61-6 free base)
T9140
Synonym:
Target: NEDD8
UbcH5c-IN-1
T13242
Synonym:
Target: Others
Cat No. Product Name Synonyms Targets
T4S0181 Hinokiflavone MMP , BCL , E1/E2/E3 Enzyme
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...
T9352 Hydrocotarnine Others
hydrocotarnine is an inhibitor of Cbl.
T4036 Solasodine Solancarpidine,Purapuridine,Solasodin Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...
T2947 Indole-3-carbinol I3C,3-Indolemethanol,Indole-3-Methanol E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T6S2123 Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1 Others , E1/E2/E3 Enzyme
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01138 UBE2S Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat...
TMPJ-01039 UBE2K Protein, Human, Recombinant (His & SUMO) Human E. coli
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPJ-01038 UBE2K Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPJ-00571 UBE2D3 Protein, Human, Recombinant Human E. coli
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPJ-01047 UBE2H Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei...
TMPJ-01198 UBE2R2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-01334 UBE2Z Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPY-00611 UBE2B Protein, Mouse, Recombinant Mouse E. coli
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPJ-00999 UBE2D1 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPJ-01221 UBE2J2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen...
TMPJ-00033 UBE2B Protein, Human, Recombinant (His) Human Human Cells
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPY-02426 UBE2D1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1), a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, which is short for stimulator of iron (Fe) transport. In other words, UbcH5A is significantly up...
TMPJ-01035 UBE2G2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPY-02607 Ube2H Protein, Human, Recombinant Human E. coli
UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPJ-01403 UBE2D4 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPJ-00985 UBE2A Protein, Human, Recombinant (GST, His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-01053 UBE2I Protein, Human, Recombinant (GST) Human E. coli
SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPJ-01100 UBE2V1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPJ-01131 UBE2V2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N....
TMPH-02764 ACSL4 Protein, Mouse, Recombinant (His) Mouse E. coli
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.
TMPH-03181 LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO) Pseudomonas azotoformans E. coli
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate comp...
TMPH-03526 Cap8A Protein, S. aureus, Recombinant (His) Staphylococcus aureus in vitro E. coli expression system
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate comp...
TMPY-02496 Rad6/UBE2A Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-02642 UBE2W Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His) Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPY-04263 UBE2T Protein, Human, Recombinant (His) Human E. coli
Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locate...
TMPJ-01327 ATG10 Protein, Human, Recombinant (His, T7) Human E. coli
Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophage...
TMPH-01492 HLA-DRA Protein, Human, Recombinant (His) Human E. coli
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubi...
TMPY-02604 UBE2D4 Protein, Human, Recombinant (His) Human E. coli
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPJ-01354 ATG3 Protein, Human, Recombinant Human E. coli
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ...
TMPY-02605 UBE2F Protein, Human, Recombinant (His) Human E. coli
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02606 UBE2G1 Protein, Human, Recombinant Human E. coli
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPY-02609 UBE2M Protein, Human, Recombinant Human E. coli
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02608 UBC9/UBE2I Protein, Human, Recombinant Human E. coli
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPH-01602 LAMA5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohe...
TMPH-01146 Human coronavirus HKU1 (isolate N5) Nucleoprotein/NP Protein (His & Myc) HCoV-HKU1 HEK293
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig...
TMPY-02391 SUMO1 Protein, Human, Recombinant (His) Human E. coli
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific pro...
TMPH-01152 Human coronavirus OC43 Non-structural protein 2a (His) HCoV-OC43 Baculovirus
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPY-02950 WWP2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPH-03033 P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) Mycoplasma pneumoniae E. coli
Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquit...
TMPY-01654 ITCH Protein, Human, Recombinant (aa 526-903) Human E. coli
E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub...
TMPH-01151 Human coronavirus NL63 Membrane protein (His) HCoV-NL63 in vitro E. coli expression system
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester...
TMPH-01150 Human coronavirus HKU1 (isolate N2) Spike glycoprotein (His) HCoV-HKU1 E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
UBE2S Protein, Human, Recombinant (GST)
TMPJ-01138
Species: Human
Expression System: E. coli
UBE2K Protein, Human, Recombinant (His & SUMO)
TMPJ-01039
Species: Human
Expression System: E. coli
UBE2K Protein, Human, Recombinant (GST)
TMPJ-01038
Species: Human
Expression System: E. coli
UBE2D3 Protein, Human, Recombinant
TMPJ-00571
Species: Human
Expression System: E. coli
UBE2H Protein, Human, Recombinant (GST)
TMPJ-01047
Species: Human
Expression System: E. coli
UBE2R2 Protein, Human, Recombinant (His)
TMPJ-01198
Species: Human
Expression System: E. coli
UBE2Z Protein, Human, Recombinant (His)
TMPJ-01334
Species: Human
Expression System: E. coli
UBE2B Protein, Mouse, Recombinant
TMPY-00611
Species: Mouse
Expression System: E. coli
UBE2D1 Protein, Human, Recombinant (GST)
TMPJ-00999
Species: Human
Expression System: E. coli
UBE2J2 Protein, Human, Recombinant (GST)
TMPJ-01221
Species: Human
Expression System: E. coli
UBE2B Protein, Human, Recombinant (His)
TMPJ-00033
Species: Human
Expression System: Human Cells
UBE2D1 Protein, Human, Recombinant (His)
TMPY-02426
Species: Human
Expression System: E. coli
UBE2G2 Protein, Human, Recombinant (GST)
TMPJ-01035
Species: Human
Expression System: E. coli
Ube2H Protein, Human, Recombinant
TMPY-02607
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (GST)
TMPJ-01403
Species: Human
Expression System: E. coli
UBE2A Protein, Human, Recombinant (GST, His)
TMPJ-00985
Species: Human
Expression System: E. coli
UBE2I Protein, Human, Recombinant (GST)
TMPJ-01053
Species: Human
Expression System: E. coli
UBE2V1 Protein, Human, Recombinant (His)
TMPJ-01100
Species: Human
Expression System: E. coli
UBE2V2 Protein, Human, Recombinant (His)
TMPJ-01131
Species: Human
Expression System: E. coli
ACSL4 Protein, Mouse, Recombinant (His)
TMPH-02764
Species: Mouse
Expression System: E. coli
LaaA Protein, Pseudomonas azotoformans, Recombinant (His & Myc & SUMO)
TMPH-03181
Species: Pseudomonas azotoformans
Expression System: E. coli
Cap8A Protein, S. aureus, Recombinant (His)
TMPH-03526
Species: Staphylococcus aureus
Expression System: in vitro E. coli expression system
Rad6/UBE2A Protein, Human, Recombinant (His)
TMPY-02496
Species: Human
Expression System: E. coli
UBE2W Protein, Human, Recombinant (His)
TMPY-02642
Species: Human
Expression System: E. coli
UBE2L6 Protein, Human, Recombinant (His)
TMPY-02842
Species: Human
Expression System: E. coli
UBE2T Protein, Human, Recombinant (His)
TMPY-04263
Species: Human
Expression System: E. coli
ATG10 Protein, Human, Recombinant (His, T7)
TMPJ-01327
Species: Human
Expression System: E. coli
HLA-DRA Protein, Human, Recombinant (His)
TMPH-01492
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (His)
TMPY-02604
Species: Human
Expression System: E. coli
ATG3 Protein, Human, Recombinant
TMPJ-01354
Species: Human
Expression System: E. coli
UBE2F Protein, Human, Recombinant (His)
TMPY-02605
Species: Human
Expression System: E. coli
UBE2G1 Protein, Human, Recombinant
TMPY-02606
Species: Human
Expression System: E. coli
UBE2M Protein, Human, Recombinant
TMPY-02609
Species: Human
Expression System: E. coli
UBC9/UBE2I Protein, Human, Recombinant
TMPY-02608
Species: Human
Expression System: E. coli
LAMA5 Protein, Human, Recombinant (His & SUMO)
TMPH-01602
Species: Human
Expression System: E. coli
Human coronavirus HKU1 (isolate N5) Nucleoprotein/NP Protein (His & Myc)
TMPH-01146
Species: HCoV-HKU1
Expression System: HEK293
SUMO1 Protein, Human, Recombinant (His)
TMPY-02391
Species: Human
Expression System: E. coli
Human coronavirus OC43 Non-structural protein 2a (His)
TMPH-01152
Species: HCoV-OC43
Expression System: Baculovirus
WWP2 Protein, Human, Recombinant (His & GST)
TMPY-02950
Species: Human
Expression System: Baculovirus-Insect Cells
P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
TMPH-03033
Species: Mycoplasma pneumoniae
Expression System: E. coli
ITCH Protein, Human, Recombinant (aa 526-903)
TMPY-01654
Species: Human
Expression System: E. coli
Human coronavirus NL63 Membrane protein (His)
TMPH-01151
Species: HCoV-NL63
Expression System: in vitro E. coli expression system
Human coronavirus HKU1 (isolate N2) Spike glycoprotein (His)
TMPH-01150
Species: HCoV-HKU1
Expression System: E. coli
Cat No. Product Name
L8600 Ubiquitination Compound Library

214 compounds
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening;
TargetMol