Cart
GPCR/G Protein Endothelin Receptor

Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Cat No. product name
T1655 Ambrisentan Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate o...
T2561 Macitentan Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T3194 Ro 46-2005 Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA rece...
T3474 RO 46-8443 RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in term...
T6258 Zibotentan Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T6264 Bosentan Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than en...
T6265 Bosentan Hydrate Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
T6672 Sitaxentan sodium Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
T6792 BQ-123 BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T5458 Darusentan Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T7817 Aprocitentan Aprocitentan is ETA and ETB antagonist .
TQ0259 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
TQ0270 Atrasentan hydrochloride Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
TQ0282 Avosentan Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
TN4606 Myriceric acid C Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
T5355 Sparsentan Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
Ambrisentan
T1655CAS 177036-94-1
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate o...
Macitentan
T2561CAS 441798-33-0
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
Ro 46-2005
T3194CAS 150725-87-4
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA rece...
RO 46-8443
T3474CAS 175556-12-4
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in term...
Zibotentan
T6258CAS 186497-07-4
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
Bosentan
T6264CAS 147536-97-8
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than en...
Bosentan Hydrate
T6265CAS 157212-55-0
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Sitaxentan sodium
T6672CAS 210421-74-2
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
BQ-123
T6792CAS 136553-81-6
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Darusentan
T5458CAS 171714-84-4
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
Aprocitentan
T7817CAS 1103522-45-7
Aprocitentan is ETA and ETB antagonist .
Atrasentan
TQ0259CAS 173937-91-2
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Atrasentan hydrochloride
TQ0270CAS 195733-43-8
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Avosentan
TQ0282CAS 290815-26-8
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
Myriceric acid C
TN4606CAS 162059-94-1
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
Sparsentan
T5355CAS 254740-64-2
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)