Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promot...
Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplast...
JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (...
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and ...
ALW-II-41-27, an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy. |
Ehp-inhibitor-1 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. |
Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. |
Tesevatinib (XL-647) is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4)...
NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4. |