Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat No.	product name
T0808	Diflunisal	Diflunisal is a cyclooxygenase (COX) Inhibitor， used as an anti-inflammatory analgesic.
T1516	Curcumin	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
T1854	MS436	MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
T1906	Molibresib	GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
T1972	GSK 5959	GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
T1973	PFI-4	PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T1993	J147	J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T2072	BET bromodomain inhibitor	BET bromodomain inhibitor is a potent BET inhibitor.
T2091	CPI-0610	CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
T2110	(+)-JQ-1HOT	(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T2120	I-BET151	I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T2127	OF-1	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T2252	UNC669	UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
T2379	UNC1215	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
T2436	GSK2801	GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T2442	CPI-203	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T2452	C646	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T2480	Apabetalone	RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217	PF-CBP1 hydrochloride	PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
T3311	GSK6853	GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T3504	AZD5153 6-Hydroxy-2-naphthoic acid	AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
T3697	3,6'-Disinapoyl sucrose	3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T3712	Mivebresib	Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
T3969	I-CBP112	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3973	PF-CBP1	PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
T3986	SF2523	SF2523 is a highly selective and potent inhibitor.
T4012	UNC 926 hydrochloride	UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
T4247	I-CBP112 hydrochloride	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
T6021	GSK1324726A	GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
T6032	Birabresib	Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
T6222	PFI-1	PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
T6255	Bromosporine	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T6668	SGC-CBP30	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T6783	BI-7273	BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
T6786	BI-9564	BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
T6811	CPI-637	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T6859	I-BRD9	I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T6939	PFI-3	A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
T6389	Anacardic Acid	Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
T4365	FL-411	FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
T4345	CeMMEC1	CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
TL0007	Bisdemethoxycurcumin	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
T4697	ABBV-744	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T6026	CPI-203	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5130	dBET6	dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T4495	dBET1	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
T6173	BI 2536HOT	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T5318	666-15	666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
T5362	Y06036	Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T5417	INCB057643	INCB057643 is a potent, selective and orally bioavailable BET inhibitor.