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Chromatin/Epigenetic Epigenetic Reader Domain

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat No. product name
T0808 Diflunisal Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
T1516 Curcumin Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
T1854 MS436 MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
T1906 Molibresib GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
T1972 GSK 5959 GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
T1973 PFI-4 PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T1993 J147 J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T2072 BET bromodomain inhibitor BET bromodomain inhibitor is a potent BET inhibitor.
T2110 (+)-JQ-1HOT (+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T2120 I-BET151 I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T2127 OF-1 OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T2252 UNC669 UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
T2379 UNC1215 UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
T2436 GSK2801 GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T2442 CPI-203 CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T2452 C646 C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T2480 Apabetalone RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217 PF-CBP1 hydrochloride PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
T3311 GSK6853 GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T3504 AZD5153 6-Hydroxy-2-naphthoic acid AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
T3697 3,6'-Disinapoyl sucrose 3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T3712 Mivebresib Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
T3969 I-CBP112 I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3973 PF-CBP1 PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
T3986 SF2523 SF2523 is a highly selective and potent inhibitor.
T4012 UNC 926 hydrochloride UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
T4247 I-CBP112 hydrochloride I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
T6021 GSK1324726A GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
T6032 Birabresib Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
T6222 PFI-1 PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
T6255 Bromosporine Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T6668 SGC-CBP30 SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T6783 BI-7273 BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
T6786 BI-9564 BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
T6811 CPI-637 CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T6859 I-BRD9 I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T6939 PFI-3 A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
T6389 Anacardic Acid Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
T4365 FL-411 FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
T4345 CeMMEC1 CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
TL0007 Bisdemethoxycurcumin Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
T4697 ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T6026 CPI-203 CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5130 dBET6 dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T4495 dBET1 dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
T6173 BI 2536HOT BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T5318 666-15 666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
T5362 Y06036 Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T5417 INCB057643 INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
T5443 JQ-1 carboxylic acid JQ-1 carboxylic acid is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
T5434 ARV-825 ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prol...
T5440 Dbet57 dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive...
T5575 Cyclogalegenol Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus.Cycloas...
T6828 ZL0420 ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program.
T7297 KG-501 KG-501 is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
T7264 CBP/EP300-IN-1 CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
TQ0083 NI-57 NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1)...
TQ0253 PLX51107 PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T7856 nAS-E nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T7863 Hexamethylene bisacetamide Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
T5468 YF-2
T2237 ICG001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
T12112 MS402 MS402 is an inhibitor of BD1-selective BET BrD (BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2) with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 8...
T12113 MS645 MS645 is an inhibitor of bivalent BET bromodomains (BrD) (Ki of 18.4 nM for BRD4-BD1/BD2).
T13785 MZP-54 MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
T13786 MZP-55 MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T12338 OXFBD04 OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).
T12346 P300/CBP-IN-5 P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T12513 PNZ5 PNZ5 is a potent and isoxazole-based pan-BET inhibitor, with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4...
T13833 PROTAC BRD4 Degrader-1 PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T13834 PROTAC BRD4 Degrader-2 PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T13835 PROTAC BRD4 Degrader-3 PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T13848 SMARCA-BD ligand 1 for Protac SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
T13849 PROTAC BET Degrader-1 PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
T13850 PROTAC BET degrader-3 PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
T12560 PROTAC BRD9 Degrader-1 PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
T14073 A-485 A-485 is an inhibitor of p300/CBP. For p300 and CBP histone acetyltransferase (HAT), the IC50s values are 9.8 nM and 2.6 nM, respectively.
T8453 UNC1079 UNC1079 is an selective L3MBTL3 domain inhibitor
T12660L BAY1238097 BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different MM (multiple myeloma) and AML ...
T14512 BAZ2-ICR BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM a...
T14550 BETd-260 BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
T14685 BMS-986158 BMS-986158 is a potent BET inhibitor. With IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (...
T12660 (Rac)-BAY1238097 (Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
T14776 BRD4 Inhibitor-10 BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T15014 CTPB CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
T15216 EML 425 EML425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T15397 GNE-049 GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, res...
T15399 GNE-207 GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-...
T15400 GNE-272 GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
T15405 GNE-781 GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, r...
T15419 GS-626510 GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
T12798 (S)-GNE-987 (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T13890 SMARCA-BD ligand 1 for Protac dihydrochloride SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T13086 I-BET762 carboxylic acid I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T13915 PROTAC BRD9-binding moiety 1 PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T13105 TD-428 TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibit...
T11136 E-7386 E-7386 is an oral active CBP/ -catenin modulator.
T11291 FKBP12 PROTAC dTAG-13 FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) ...
T11292 FKBP12 PROTAC dTAG-7 FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ...
T10520 BET-IN-2 BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
T10521 BET-IN-4 BET-IN-4 is a potent BRD4 inhibitor (IC50 ≤ 1 μM).
T10522 BET-IN-6 BET-IN-6 is an effective and high-affinity inhibitor of BRD2/BRD4. It is the ligand for target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 ...
T10641 C-82 C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T10702 CBP/EP300-IN-2 CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
T10717 CBP-IN-1 CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
T11441 GNE-987 GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a po...
T13715 GSK9311 hydrochloride GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. GSK9311 hydrochloride, a less active analog...
T11597 IACS-9571 IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively....
T11597L IACS-9571 Hydrochloride IACS-9571 Hydrochloride is a selective and  potent inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and B...
T13190 TP-472 TP-472 is a selective inhibitor of BRD9(Kd of 33 nM).
T10773 CF53 CF53 is a highly potent, selective, and orally active inhibitor of BET protein (Ki: <1 nM, Kd: 2.2 nM, IC50: 2 nM for BRD4 BD1).
T13715L GSK9311 GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analogue of GSK6853. It can be used as negati...
T15443 GSK8814 GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s of 7.3 and 4.6, respectively). GSK8814 is a selective...
T15484 HJB97 HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1...
T11563 Histone Acetyltransferase Inhibitor II Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity ...
T19618 (R)-(-)-JQ1 Enantiomer (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T15441 GSK8573 GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
T17311 (+)-JQ1 PA (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T16154 MS417 MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP B...
T10879 CPI-0610 carboxylic acid CPI-0610 carboxylic acid is a ligand for target protein for PROTAC. It is a potent bromodomain and extra-terminal (BET) protein inhibitor with the potential in ...
T13366 YHO-13351 YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
T13396 Zinc Protoporphyrin Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (P...
T19608 Zinc sulfate heptahydrate Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk.
T13397 ZINC03129319 ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
T13412 ZM223 ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
T13977 (R)-UT-155 (R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
T15794 LUT014 LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
T16139 MRS2698 MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recept...
TP2149L NP213 NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-funga...
T11887 LT052 LT052 shows nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2. LT052 has inhibitory activities against BRPF1b (IC50=567.5 nM). LT052 has anti-in...
T17147 TPOP146 TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T17249 VZ185 VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T17294 ZL0454 ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
T17297 ZXH-3-26 ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T22345 INCB054329 INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, B...
T8658 NEO2734 NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T19935 XD14 XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), re...
Diflunisal
T0808CAS 22494-42-4
Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
Curcumin
T1516CAS 458-37-7
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
MS436
T1854CAS 1395084-25-9
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
Molibresib
T1906CAS 1260907-17-2
GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
GSK 5959
T1972CAS 901245-65-6
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
PFI-4
T1973CAS 900305-37-5
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
J147
T1993CAS 1146963-51-0
J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
BET bromodomain inhibitor
T2072CAS 1505453-59-7
BET bromodomain inhibitor is a potent BET inhibitor.
(+)-JQ-1 HOT
T2110CAS 1268524-70-4
(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
I-BET151
T2120CAS 1300031-49-5
I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
OF-1
T2127CAS 919973-83-4
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
UNC669
T2252CAS 1314241-44-5
UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
UNC1215
T2379CAS 1415800-43-9
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
GSK2801
T2436CAS 1619994-68-1
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
CPI-203
T2442CAS 202591-23-9
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
C646
T2452CAS 328968-36-1
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
Apabetalone
T2480CAS 1044870-39-4
RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
PF-CBP1 hydrochloride
T3217CAS 2070014-93-4
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
GSK6853
T3311CAS 1910124-24-1
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
AZD5153 6-Hydroxy-2-naphthoic acid
T3504CAS 1869912-40-2
AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
3,6'-Disinapoyl sucrose
T3697CAS 139891-98-8
3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
Mivebresib
T3712CAS 1445993-26-9
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
I-CBP112
T3969CAS 1640282-31-0
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
PF-CBP1
T3973CAS 1962928-21-7
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
SF2523
T3986CAS 1174428-47-7
SF2523 is a highly selective and potent inhibitor.
UNC 926 hydrochloride
T4012CAS 1184136-10-4
UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
I-CBP112 hydrochloride
T4247CAS 2147701-33-3
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
GSK1324726A
T6021CAS 1300031-52-0
GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
Birabresib
T6032CAS 202590-98-5
Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
PFI-1
T6222CAS 1403764-72-6
PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
Bromosporine
T6255CAS 1619994-69-2
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
SGC-CBP30
T6668CAS 1613695-14-9
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
BI-7273
T6783CAS 1883429-21-7
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
BI-9564
T6786CAS 1883429-22-8
BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
CPI-637
T6811CAS 1884712-47-3
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
I-BRD9
T6859CAS 1714146-59-4
I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
PFI-3
T6939CAS 1819363-80-8
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
Anacardic Acid
T6389CAS 16611-84-0
Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
FL-411
T4365CAS 2118944-88-8
FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
CeMMEC1
T4345CAS 440662-09-9
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
Bisdemethoxycurcumin
TL0007CAS 24939-16-0
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
ABBV-744
T4697CAS 2138861-99-9
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
CPI-203
T6026CAS 1446144-04-2
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
dBET6
T5130CAS 1950634-92-0
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
dBET1
T4495CAS 1799711-21-9
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
BI 2536 HOT
T6173CAS 755038-02-9
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
666-15
T5318CAS 1433286-70-4
666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
Y06036
T5362CAS 1832671-96-1
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
INCB057643
T5417CAS 1820889-23-3
INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
JQ-1 carboxylic acid
T5443CAS 202592-23-2
JQ-1 carboxylic acid is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
ARV-825
T5434CAS 1818885-28-7
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prol...
Dbet57
T5440CAS 1883863-52-2
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive...
Cyclogalegenol
T5575CAS 78574-94-4
Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus.Cycloas...
ZL0420
T6828CAS 2229039-45-4
ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program.
KG-501
T7297CAS 18228-17-6
KG-501 is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
CBP/EP300-IN-1
T7264CAS T7264
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
NI-57
TQ0083CAS 1883548-89-7
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1)...
PLX51107
TQ0253CAS 1627929-55-8
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
nAS-E
T7856CAS 92-78-4
nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
Hexamethylene bisacetamide
T7863CAS 3073-59-4
Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
YF-2
T5468CAS 1311423-89-8
ICG001
T2237CAS 847591-62-2
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
MS402
T12112CAS 1672684-68-2
MS402 is an inhibitor of BD1-selective BET BrD (BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2) with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 8...
MS645
T12113CAS 2250091-96-2
MS645 is an inhibitor of bivalent BET bromodomains (BrD) (Ki of 18.4 nM for BRD4-BD1/BD2).
MZP-54
T13785CAS 2010159-47-2
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
MZP-55
T13786CAS 2010159-48-3
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
OXFBD04
T12338CAS 2231747-03-6
OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).
P300/CBP-IN-5
T12346CAS 1889284-33-6
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
PNZ5
T12513CAS 1629277-36-6
PNZ5 is a potent and isoxazole-based pan-BET inhibitor, with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4...
PROTAC BRD4 Degrader-1
T13833CAS 2133360-00-4
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
PROTAC BRD4 Degrader-2
T13834CAS 2185795-53-1
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
PROTAC BRD4 Degrader-3
T13835CAS 2313234-00-1
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
SMARCA-BD ligand 1 for Protac
T13848CAS 1997319-92-2
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
PROTAC BET Degrader-1
T13849CAS 2093386-22-0
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
PROTAC BET degrader-3
T13850CAS T13850
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
PROTAC BRD9 Degrader-1
T12560CAS 2097971-01-0
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
A-485
T14073CAS 1889279-16-6
A-485 is an inhibitor of p300/CBP. For p300 and CBP histone acetyltransferase (HAT), the IC50s values are 9.8 nM and 2.6 nM, respectively.
UNC1079
T8453CAS 1418741-86-2
UNC1079 is an selective L3MBTL3 domain inhibitor
BAY1238097
T12660LCAS 1564268-08-1
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different MM (multiple myeloma) and AML ...
BAZ2-ICR
T14512CAS 1665195-94-7
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM a...
BETd-260
T14550CAS 2093388-62-4
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
BMS-986158
T14685CAS 1800340-40-2
BMS-986158 is a potent BET inhibitor. With IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (...
(Rac)-BAY1238097
T12660CAS 1564268-19-4
(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
BRD4 Inhibitor-10
T14776CAS 1660117-38-3
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
CTPB
T15014CAS 586976-24-1
CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
EML 425
T15216CAS 1675821-32-5
EML425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
GNE-049
T15397CAS 1936421-41-8
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, res...
GNE-207
T15399CAS 2158266-58-9
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-...
GNE-272
T15400CAS 1936428-93-1
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
GNE-781
T15405CAS 1936422-33-1
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, r...
GS-626510
T15419CAS 1637770-13-8
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
(S)-GNE-987
T12798CAS T12798
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
SMARCA-BD ligand 1 for Protac dihydrochloride
T13890CAS 2369053-68-7
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
I-BET762 carboxylic acid
T13086CAS 1300019-38-8
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
PROTAC BRD9-binding moiety 1
T13915CAS 2097512-23-5
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
TD-428
T13105CAS T13105
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibit...
E-7386
T11136CAS 1799824-08-0
E-7386 is an oral active CBP/ -catenin modulator.
FKBP12 PROTAC dTAG-13
T11291CAS 2064175-41-1
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) ...
FKBP12 PROTAC dTAG-7
T11292CAS 2064175-32-0
FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ...
BET-IN-2
T10520CAS 2104688-91-5
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
BET-IN-4
T10521CAS 1801503-93-4
BET-IN-4 is a potent BRD4 inhibitor (IC50 ≤ 1 μM).
BET-IN-6
T10522CAS T10522
BET-IN-6 is an effective and high-affinity inhibitor of BRD2/BRD4. It is the ligand for target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 ...
C-82
T10641CAS 1422253-37-9
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
CBP/EP300-IN-2
T10702CAS 2158265-96-2
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
CBP-IN-1
T10717CAS 2222941-37-7
CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
GNE-987
T11441CAS T11441
GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a po...
GSK9311 hydrochloride
T13715CAS 2253733-09-2
GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. GSK9311 hydrochloride, a less active analog...
IACS-9571
T11597CAS 1800477-30-8
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively....
IACS-9571 Hydrochloride
T11597LCAS T11597L
IACS-9571 Hydrochloride is a selective and  potent inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and B...
TP-472
T13190CAS 2079895-62-6
TP-472 is a selective inhibitor of BRD9(Kd of 33 nM).
CF53
T10773CAS 1808160-52-2
CF53 is a highly potent, selective, and orally active inhibitor of BET protein (Ki: <1 nM, Kd: 2.2 nM, IC50: 2 nM for BRD4 BD1).
GSK9311
T13715LCAS 1923851-49-3
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analogue of GSK6853. It can be used as negati...
GSK8814
T15443CAS 1997369-78-4
GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s of 7.3 and 4.6, respectively). GSK8814 is a selective...
HJB97
T15484CAS 2093391-24-1
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1...
Histone Acetyltransferase Inhibitor II
T11563CAS 932749-62-7
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity ...
(R)-(-)-JQ1 Enantiomer
T19618CAS 1268524-71-5
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
GSK8573
T15441CAS 1693766-04-9
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
(+)-JQ1 PA
T17311CAS 2115701-93-2
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
MS417
T16154CAS 916489-36-6
MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP B...
CPI-0610 carboxylic acid
T10879CAS 1380089-81-5
CPI-0610 carboxylic acid is a ligand for target protein for PROTAC. It is a potent bromodomain and extra-terminal (BET) protein inhibitor with the potential in ...
YHO-13351
T13366CAS 1346753-00-1
YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
Zinc Protoporphyrin
T13396CAS 15442-64-5
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (P...
Zinc sulfate heptahydrate
T19608CAS 7446-20-0
Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk.
ZINC03129319
T13397CAS 1777807-64-3
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
ZM223
T13412CAS 2031177-48-5
ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
(R)-UT-155
T13977CAS 2031161-54-1
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
LUT014
T15794CAS 2274819-46-2
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
MRS2698
T16139CAS 934014-05-8
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recept...
NP213
TP2149LCAS 942577-31-3
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-funga...
LT052
T11887CAS T11887
LT052 shows nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2. LT052 has inhibitory activities against BRPF1b (IC50=567.5 nM). LT052 has anti-in...
TPOP146
T17147CAS 2018300-62-2
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
VZ185
T17249CAS 2306193-61-1
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
ZL0454
T17294CAS 2229042-77-5
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
ZXH-3-26
T17297CAS 2243076-67-5
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
INCB054329
T22345CAS 1628607-64-6
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, B...
NEO2734
T8658CAS 2081072-29-7
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
XD14
T19935CAS 1370888-71-3
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), re...