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Chromatin/Epigenetic Epigenetic Reader Domain

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat No. product name
T0808 Diflunisal Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
T1516 Curcumin Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
T1854 MS436 MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
T1906 Molibresib GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
T1972 GSK 5959 GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
T1973 PFI-4 PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T1993 J147 J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T2072 BET bromodomain inhibitor BET bromodomain inhibitor is a potent BET inhibitor.
T2091 CPI-0610 CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
T2110 (+)-JQ-1HOT (+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T2120 I-BET151 I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T2127 OF-1 OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T2252 UNC669 UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
T2379 UNC1215 UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
T2436 GSK2801 GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T2442 CPI-203 CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T2452 C646 C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T2480 Apabetalone RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217 PF-CBP1 hydrochloride PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
T3311 GSK6853 GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T3504 AZD5153 6-Hydroxy-2-naphthoic acid AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
T3697 3,6'-Disinapoyl sucrose 3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T3712 Mivebresib Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
T3969 I-CBP112 I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3973 PF-CBP1 PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
T3986 SF2523 SF2523 is a highly selective and potent inhibitor.
T4012 UNC 926 hydrochloride UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
T4247 I-CBP112 hydrochloride I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
T6021 GSK1324726A GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
T6032 Birabresib Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
T6222 PFI-1 PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
T6255 Bromosporine Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T6668 SGC-CBP30 SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T6783 BI-7273 BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
T6786 BI-9564 BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
T6811 CPI-637 CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T6859 I-BRD9 I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T6939 PFI-3 A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
T6389 Anacardic Acid Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
T4365 FL-411 FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
T4345 CeMMEC1 CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
TL0007 Bisdemethoxycurcumin Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
T4697 ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T6026 CPI-203 CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5130 dBET6 dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T4495 dBET1 dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
T6173 BI 2536HOT BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T5318 666-15 666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
T5362 Y06036 Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T5417 INCB057643 INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
Diflunisal
T0808CAS 22494-42-4
Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
Curcumin
T1516CAS 458-37-7
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
MS436
T1854CAS 1395084-25-9
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
Molibresib
T1906CAS 1260907-17-2
GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
GSK 5959
T1972CAS 901245-65-6
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
PFI-4
T1973CAS 900305-37-5
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
J147
T1993CAS 1146963-51-0
J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
BET bromodomain inhibitor
T2072CAS 1505453-59-7
BET bromodomain inhibitor is a potent BET inhibitor.
CPI-0610
T2091CAS 1380087-89-7
CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
(+)-JQ-1 HOT
T2110CAS 1268524-70-4
(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
I-BET151
T2120CAS 1300031-49-5
I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
OF-1
T2127CAS 919973-83-4
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
UNC669
T2252CAS 1314241-44-5
UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
UNC1215
T2379CAS 1415800-43-9
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
GSK2801
T2436CAS 1619994-68-1
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
CPI-203
T2442CAS 202591-23-9
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
C646
T2452CAS 328968-36-1
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
Apabetalone
T2480CAS 1044870-39-4
RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
PF-CBP1 hydrochloride
T3217CAS 2070014-93-4
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
GSK6853
T3311CAS 1910124-24-1
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
AZD5153 6-Hydroxy-2-naphthoic acid
T3504CAS 1869912-40-2
AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
3,6'-Disinapoyl sucrose
T3697CAS 139891-98-8
3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
Mivebresib
T3712CAS 1445993-26-9
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
I-CBP112
T3969CAS 1640282-31-0
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
PF-CBP1
T3973CAS 1962928-21-7
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
SF2523
T3986CAS 1174428-47-7
SF2523 is a highly selective and potent inhibitor.
UNC 926 hydrochloride
T4012CAS 1184136-10-4
UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
I-CBP112 hydrochloride
T4247CAS 2147701-33-3
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
GSK1324726A
T6021CAS 1300031-52-0
GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
Birabresib
T6032CAS 202590-98-5
Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
PFI-1
T6222CAS 1403764-72-6
PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
Bromosporine
T6255CAS 1619994-69-2
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
SGC-CBP30
T6668CAS 1613695-14-9
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
BI-7273
T6783CAS 1883429-21-7
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
BI-9564
T6786CAS 1883429-22-8
BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
CPI-637
T6811CAS 1884712-47-3
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
I-BRD9
T6859CAS 1714146-59-4
I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
PFI-3
T6939CAS 1819363-80-8
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
Anacardic Acid
T6389CAS 16611-84-0
Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
FL-411
T4365CAS 2118944-88-8
FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
CeMMEC1
T4345CAS 440662-09-9
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
Bisdemethoxycurcumin
TL0007CAS 24939-16-0
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
ABBV-744
T4697CAS 2138861-99-9
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
CPI-203
T6026CAS 1446144-04-2
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
dBET6
T5130CAS 1950634-92-0
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
dBET1
T4495CAS 1799711-21-9
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
BI 2536 HOT
T6173CAS 755038-02-9
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
666-15
T5318CAS 1433286-70-4
666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
Y06036
T5362CAS 1832671-96-1
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
INCB057643
T5417CAS 1820889-23-3
INCB057643 is a potent, selective and orally bioavailable BET inhibitor.