Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat No.	product name
T0808	Diflunisal	Diflunisal is a cyclooxygenase (COX) Inhibitor， used as an anti-inflammatory analgesic.
T1516	Curcumin	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
T1854	MS436	MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
T1906	Molibresib	GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
T1972	GSK 5959	GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
T1973	PFI-4	PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T1993	J147	J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T2072	BET bromodomain inhibitor	BET bromodomain inhibitor is a potent BET inhibitor.
T2110	(+)-JQ-1HOT	(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T2120	I-BET151	I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T2127	OF-1	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T2252	UNC669	UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
T2379	UNC1215	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
T2436	GSK2801	GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T2442	CPI-203	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T2452	C646	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T2480	Apabetalone	RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217	PF-CBP1 hydrochloride	PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
T3311	GSK6853	GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T3504	AZD5153 6-Hydroxy-2-naphthoic acid	AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
T3697	3,6'-Disinapoyl sucrose	3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T3712	Mivebresib	Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
T3969	I-CBP112	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3973	PF-CBP1	PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
T3986	SF2523	SF2523 is a highly selective and potent inhibitor.
T4012	UNC 926 hydrochloride	UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
T4247	I-CBP112 hydrochloride	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
T6021	GSK1324726A	GSK1324726A is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
T6032	Birabresib	Birabresib is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potent...
T6222	PFI-1	PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
T6255	Bromosporine	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T6668	SGC-CBP30	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T6783	BI-7273	BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
T6786	BI-9564	BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
T6811	CPI-637	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T6859	I-BRD9	I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T6939	PFI-3	A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
T6389	Anacardic Acid	Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial act...
T4365	FL-411	FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
T4345	CeMMEC1	CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
TL0007	Bisdemethoxycurcumin	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
T4697	ABBV-744	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T6026	CPI-203	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5130	dBET6	dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T4495	dBET1	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
T6173	BI 2536HOT	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T5318	666-15	666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
T5362	Y06036	Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T5417	INCB057643	INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
T5443	JQ-1 carboxylic acid	JQ-1 carboxylic acid is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
T5434	ARV-825	ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prol...
T5440	Dbet57	dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive...
T5575	Cyclogalegenol	Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus.Cycloas...
T6828	ZL0420	ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program.
T7297	KG-501	KG-501 is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
T7264	CBP/EP300-IN-1	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
TQ0083	NI-57	NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1)...
TQ0253	PLX51107	PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T7856	nAS-E	nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T7863	Hexamethylene bisacetamide	Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
T5468	YF-2
T2237	ICG001	ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
T12112	MS402	MS402 is an inhibitor of BD1-selective BET BrD (BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2) with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 8...
T12113	MS645	MS645 is an inhibitor of bivalent BET bromodomains (BrD) (Ki of 18.4 nM for BRD4-BD1/BD2).
T13785	MZP-54	MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
T13786	MZP-55	MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T12338	OXFBD04	OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).
T12346	P300/CBP-IN-5	P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T12513	PNZ5	PNZ5 is a potent and isoxazole-based pan-BET inhibitor, with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4...
T13833	PROTAC BRD4 Degrader-1	PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T13834	PROTAC BRD4 Degrader-2	PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T13835	PROTAC BRD4 Degrader-3	PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T13848	SMARCA-BD ligand 1 for Protac	SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
T13849	PROTAC BET Degrader-1	PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
T13850	PROTAC BET degrader-3	PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
T12560	PROTAC BRD9 Degrader-1	PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
T14073	A-485	A-485 is an inhibitor of p300/CBP. For p300 and CBP histone acetyltransferase (HAT), the IC50s values are 9.8 nM and 2.6 nM, respectively.
T8453	UNC1079	UNC1079 is an selective L3MBTL3 domain inhibitor
T12660L	BAY1238097	BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different MM (multiple myeloma) and AML ...
T14512	BAZ2-ICR	BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM a...
T14550	BETd-260	BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
T14685	BMS-986158	BMS-986158 is a potent BET inhibitor. With IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (...
T12660	(Rac)-BAY1238097	(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
T14776	BRD4 Inhibitor-10	BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T15014	CTPB	CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
T15216	EML 425	EML425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T15397	GNE-049	GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, res...
T15399	GNE-207	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-...
T15400	GNE-272	GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
T15405	GNE-781	GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, r...
T15419	GS-626510	GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
T12798	(S)-GNE-987	(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T13890	SMARCA-BD ligand 1 for Protac dihydrochloride	SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T13086	I-BET762 carboxylic acid	I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T13915	PROTAC BRD9-binding moiety 1	PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T13105	TD-428	TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibit...
T11136	E-7386	E-7386 is an oral active CBP/ -catenin modulator.
T11291	FKBP12 PROTAC dTAG-13	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) ...
T11292	FKBP12 PROTAC dTAG-7	FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ...
T10520	BET-IN-2	BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
T10521	BET-IN-4	BET-IN-4 is a potent BRD4 inhibitor (IC50 ≤ 1 μM).
T10522	BET-IN-6	BET-IN-6 is an effective and high-affinity inhibitor of BRD2/BRD4. It is the ligand for target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 ...
T10641	C-82	C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T10702	CBP/EP300-IN-2	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
T10717	CBP-IN-1	CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
T11441	GNE-987	GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a po...
T13715	GSK9311 hydrochloride	GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. GSK9311 hydrochloride, a less active analog...
T11597	IACS-9571	IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively....
T11597L	IACS-9571 Hydrochloride	IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and B...
T13190	TP-472	TP-472 is a selective inhibitor of BRD9(Kd of 33 nM).
T10773	CF53	CF53 is a highly potent, selective, and orally active inhibitor of BET protein (Ki: <1 nM, Kd: 2.2 nM, IC50: 2 nM for BRD4 BD1).
T13715L	GSK9311	GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analogue of GSK6853. It can be used as negati...
T15443	GSK8814	GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s of 7.3 and 4.6, respectively). GSK8814 is a selective...
T15484	HJB97	HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1...
T11563	Histone Acetyltransferase Inhibitor II	Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity ...
T19618	(R)-(-)-JQ1 Enantiomer	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T15441	GSK8573	GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
T17311	(+)-JQ1 PA	(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T16154	MS417	MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP B...
T10879	CPI-0610 carboxylic acid	CPI-0610 carboxylic acid is a ligand for target protein for PROTAC. It is a potent bromodomain and extra-terminal (BET) protein inhibitor with the potential in ...
T13366	YHO-13351	YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
T13396	Zinc Protoporphyrin	Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (P...
T19608	Zinc sulfate heptahydrate	Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk.
T13397	ZINC03129319	ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
T13412	ZM223	ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
T13977	(R)-UT-155	(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
T15794	LUT014	LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
T16139	MRS2698	MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recept...
TP2149L	NP213	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-funga...
T11887	LT052	LT052 shows nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2. LT052 has inhibitory activities against BRPF1b (IC50=567.5 nM). LT052 has anti-in...
T17147	TPOP146	TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T17249	VZ185	VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T17294	ZL0454	ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
T17297	ZXH-3-26	ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T22345	INCB054329	INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, B...
T8658	NEO2734	NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T19935	XD14	XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), re...