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Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1843 XMD8-92 1234480-50-2 98.19%
XMD8-92
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
T6859 I-BRD9 1714146-59-4 98.16%
I-BRD9
I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
T17350 ACBI1 2375564-55-7 98.15%
ACBI1
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
T2480 Apabetalone 1044870-39-4 98.08%
Apabetalone
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
T72058L CDD-1102 HCl 98.05%
CDD-1102  HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.
T19618 (R)-(-)-JQ1 Enantiomer 1268524-71-5 98.03%
(R)-(-)-JQ1 Enantiomer
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T22345 INCB054329 1628607-64-6 98.03%
INCB054329
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BR...
T7264 CBP/EP300-IN-1 2443789-32-8 98%
CBP/EP300-IN-1
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
T14510 BAY-850 2099142-76-2 98%
BAY-850
BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasi...
T7297 KG-501 18228-17-6 98%
KG-501
KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
T1973 PFI-4 900305-37-5 98%
PFI-4
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T2127 OF-1 919973-83-4 98%
OF-1
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T7863 Hexamethylene bisacetamide 3073-59-4 98%
Hexamethylene bisacetamide
Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
T5442 A1874 2064292-12-0 98%
A1874
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
T3986 SF2523 1174428-47-7 97.78%
SF2523
SF2523 is a highly selective and potent inhibitor.
T6828 ZL0420 2229039-45-4 97.77%
ZL0420
ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has...
T5434 ARV-825 1818885-28-7 97.54%
ARV-825
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
T14502 BAY-299 2080306-23-4 97.5%
BAY-299
BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with I...
T2649 Menin-MLL inhibitor MI-2 1271738-62-5 97.46%
Menin-MLL inhibitor MI-2
Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
T13393 ZEN-3411 1952264-36-6 97.42%
ZEN-3411
ZEN-3411 is an orally available and potent BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproduc...
XMD8-92
T1843
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
I-BRD9
T6859
I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
ACBI1
T17350
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
Apabetalone
T2480
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
CDD-1102 HCl
T72058L
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.
(R)-(-)-JQ1 Enantiomer
T19618
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
INCB054329
T22345
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BR...
CBP/EP300-IN-1
T7264
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
BAY-850
T14510
BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasi...
KG-501
T7297
KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
PFI-4
T1973
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
OF-1
T2127
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
Hexamethylene bisacetamide
T7863
Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
A1874
T5442
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
SF2523
T3986
SF2523 is a highly selective and potent inhibitor.
ZL0420
T6828
ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has...
ARV-825
T5434
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
BAY-299
T14502
BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with I...
Menin-MLL inhibitor MI-2
T2649
Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
ZEN-3411
T13393
ZEN-3411 is an orally available and potent BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproduc...
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TargetMol