T1843 |
XMD8-92
|
1234480-50-2
|
98.19%
|
|
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
|
T6859 |
I-BRD9
|
1714146-59-4
|
98.16%
|
|
I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
|
T17350 |
ACBI1
|
2375564-55-7
|
98.15%
|
|
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
|
T2480 |
Apabetalone
|
1044870-39-4
|
98.08%
|
|
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
|
T72058L |
CDD-1102 HCl
|
|
98.05%
|
|
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.
|
T19618 |
(R)-(-)-JQ1 Enantiomer
|
1268524-71-5
|
98.03%
|
|
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
|
T22345 |
INCB054329
|
1628607-64-6
|
98.03%
|
|
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BR...
|
T7264 |
CBP/EP300-IN-1
|
2443789-32-8
|
98%
|
|
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
|
T14510 |
BAY-850
|
2099142-76-2
|
98%
|
|
BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasi...
|
T7297 |
KG-501
|
18228-17-6
|
98%
|
|
KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).
|
T1973 |
PFI-4
|
900305-37-5
|
98%
|
|
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
|
T2127 |
OF-1
|
919973-83-4
|
98%
|
|
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
|
T7863 |
Hexamethylene bisacetamide
|
3073-59-4
|
98%
|
|
Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.
|
T5442 |
A1874
|
2064292-12-0
|
98%
|
|
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
|
T3986 |
SF2523
|
1174428-47-7
|
97.78%
|
|
SF2523 is a highly selective and potent inhibitor.
|
T6828 |
ZL0420
|
2229039-45-4
|
97.77%
|
|
ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has...
|
T5434 |
ARV-825
|
1818885-28-7
|
97.54%
|
|
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolo...
|
T14502 |
BAY-299
|
2080306-23-4
|
97.5%
|
|
BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with I...
|
T2649 |
Menin-MLL inhibitor MI-2
|
1271738-62-5
|
97.46%
|
|
Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
|
T13393 |
ZEN-3411
|
1952264-36-6
|
97.42%
|
|
ZEN-3411 is an orally available and potent BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproduc...
|