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Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79034 GXF-111 98%
GXF-111
GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high bindi...
T79065 WWL0245 2869057-11-2 98%
WWL0245
WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1 ...
T79084 BET bromodomain inhibitor 3 854137-39-6 98%
BET bromodomain inhibitor 3
BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraceptio...
T79093 Bromodomain inhibitor-12 2010124-06-6 98%
Bromodomain inhibitor-12
Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].
T79094 Bromodomain inhibitor-12 (edisylate) 2010124-27-1 98%
Bromodomain inhibitor-12 (edisylate)
Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].
T79117 Menin-MLL inhibitor 27 98%
Menin-MLL inhibitor 27
Menin-MLL inhibitor 27 effectively inhibits the interaction between Menin and MLL, serving as a potential tool in cancer research, particularly for acute myeloid...
T79167 BET-IN-15 2408994-22-7 98%
BET-IN-15
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exh...
T79168 CBP-IN-1 1936431-44-5 98%
CBP-IN-1
CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM an...
T79395 CBP/p300-IN-21 1065581-69-2 98%
CBP/p300-IN-21
CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits th...
T79527 BET BD2-IN-1 98%
BET BD2-IN-1
BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM. It suppresses Th17 cell differentiation through the r...
T79610 BET-IN-17 98%
BET-IN-17
BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].
T79642 IV-275 98%
IV-275
IV-275 is a dual inhibitor targeting the bromodomains of both BRG1 and BRM. This compound not only augments DNA damage when combined with Temozolomide and Bleomy...
T79737 Menin-MLL inhibitor 29 98%
Menin-MLL inhibitor 29
Menin-MLL Inhibitor 29 (Compound C1) is a Menin-MLL protein-protein interaction (PPI) inhibitor that demonstrates high affinity to Menin with a dissociation cons...
T79768 HDAC/JAK/BRD4-IN-1 2755325-84-7 98%
HDAC/JAK/BRD4-IN-1
HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induce...
T79801 TCIP 1 98%
TCIP 1
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL...
T79818 PROTAC BRD4 Degrader-21 2503036-46-0 98%
PROTAC BRD4 Degrader-21
PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its pote...
T79820 SMD-3040 98%
SMD-3040
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellen...
T79889 DBr-1 98%
DBr-1
DBr-1 is a potent degrader of BRD9 [1].
T80423 Phoenixin-20 1415039-77-8 98%
Phoenixin-20
Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian...
T80424 Phoenixin-20 TFA 98%
Phoenixin-20 TFA
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones and ...
GXF-111
T79034
GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high bindi...
WWL0245
T79065
WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1 ...
BET bromodomain inhibitor 3
T79084
BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraceptio...
Bromodomain inhibitor-12
T79093
Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].
Bromodomain inhibitor-12 (edisylate)
T79094
Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].
Menin-MLL inhibitor 27
T79117
Menin-MLL inhibitor 27 effectively inhibits the interaction between Menin and MLL, serving as a potential tool in cancer research, particularly for acute myeloid...
BET-IN-15
T79167
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exh...
CBP-IN-1
T79168
CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM an...
CBP/p300-IN-21
T79395
CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits th...
BET BD2-IN-1
T79527
BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM. It suppresses Th17 cell differentiation through the r...
BET-IN-17
T79610
BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].
IV-275
T79642
IV-275 is a dual inhibitor targeting the bromodomains of both BRG1 and BRM. This compound not only augments DNA damage when combined with Temozolomide and Bleomy...
Menin-MLL inhibitor 29
T79737
Menin-MLL Inhibitor 29 (Compound C1) is a Menin-MLL protein-protein interaction (PPI) inhibitor that demonstrates high affinity to Menin with a dissociation cons...
HDAC/JAK/BRD4-IN-1
T79768
HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induce...
TCIP 1
T79801
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL...
PROTAC BRD4 Degrader-21
T79818
PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its pote...
SMD-3040
T79820
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellen...
DBr-1
T79889
DBr-1 is a potent degrader of BRD9 [1].
Phoenixin-20
T80423
Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian...
Phoenixin-20 TFA
T80424
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones and ...
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