T79034 |
GXF-111
|
|
98%
|
|
GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high bindi...
|
T79065 |
WWL0245
|
2869057-11-2
|
98%
|
|
WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1 ...
|
T79084 |
BET bromodomain inhibitor 3
|
854137-39-6
|
98%
|
|
BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraceptio...
|
T79093 |
Bromodomain inhibitor-12
|
2010124-06-6
|
98%
|
|
Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].
|
T79094 |
Bromodomain inhibitor-12 (edisylate)
|
2010124-27-1
|
98%
|
|
Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].
|
T79117 |
Menin-MLL inhibitor 27
|
|
98%
|
|
Menin-MLL inhibitor 27 effectively inhibits the interaction between Menin and MLL, serving as a potential tool in cancer research, particularly for acute myeloid...
|
T79167 |
BET-IN-15
|
2408994-22-7
|
98%
|
|
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exh...
|
T79168 |
CBP-IN-1
|
1936431-44-5
|
98%
|
|
CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM an...
|
T79395 |
CBP/p300-IN-21
|
1065581-69-2
|
98%
|
|
CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits th...
|
T79527 |
BET BD2-IN-1
|
|
98%
|
|
BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM. It suppresses Th17 cell differentiation through the r...
|
T79610 |
BET-IN-17
|
|
98%
|
|
BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].
|
T79642 |
IV-275
|
|
98%
|
|
IV-275 is a dual inhibitor targeting the bromodomains of both BRG1 and BRM. This compound not only augments DNA damage when combined with Temozolomide and Bleomy...
|
T79737 |
Menin-MLL inhibitor 29
|
|
98%
|
|
Menin-MLL Inhibitor 29 (Compound C1) is a Menin-MLL protein-protein interaction (PPI) inhibitor that demonstrates high affinity to Menin with a dissociation cons...
|
T79768 |
HDAC/JAK/BRD4-IN-1
|
2755325-84-7
|
98%
|
|
HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induce...
|
T79801 |
TCIP 1
|
|
98%
|
|
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL...
|
T79818 |
PROTAC BRD4 Degrader-21
|
2503036-46-0
|
98%
|
|
PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its pote...
|
T79820 |
SMD-3040
|
|
98%
|
|
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellen...
|
T79889 |
DBr-1
|
|
98%
|
|
DBr-1 is a potent degrader of BRD9 [1].
|
T80423 |
Phoenixin-20
|
1415039-77-8
|
98%
|
|
Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian...
|
T80424 |
Phoenixin-20 TFA
|
|
98%
|
|
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones and ...
|