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Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T12346 CBP/p300-IN-5 1889284-33-6 98%
CBP/p300-IN-5
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T13366 YHO-13351 1346753-00-1 98%
YHO-13351
YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
T36573 NHWD-870 2115742-03-3 98%
NHWD-870
NHWD-870 is an effective and selective inhibitor of BET family bromodomain only binding to BRD2, BRD3, BRD4 (IC50 = 2.7 nM), and BRDT. NHWD-870 exhibits potent a...
T15400 GNE-272 1936428-93-1 98%
GNE-272
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
T5439 BRD4 degrader AT1 2098836-45-2 98%
BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
T11597L IACS-9571 Hydrochloride (1800477-30-8 free base) T11597L 98%
IACS-9571 Hydrochloride (1800477-30-8 free base)
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
T11441 GNE-987 2417371-71-0 98%
GNE-987
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
TQ0069 MI-503 1857417-13-0 99.99%
MI-503
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
T5575 Cycloastragenol 78574-94-4 99.98%
Cycloastragenol
Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus m...
T60072 ZL0590 2230496-99-6 99.95%
ZL0590
ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.
T6032 Birabresib 202590-98-5 99.93%
Birabresib
Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 wi...
T10638L AW68 2247236-61-7 99.92%
AW68
AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.
T15405 GNE-781 1936422-33-1 99.92%
GNE-781
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, re...
T3973 PF-CBP1 1962928-21-7 99.91%
PF-CBP1
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 36...
T6811 CPI-637 1884712-47-3 99.91%
CPI-637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T9552 BAZ1A-IN-1 941521-45-5 99.91%
BAZ1A-IN-1
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell l...
T60158 PBRM1-BD2-IN-3 2819989-58-5 99.91%
PBRM1-BD2-IN-3
PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.
T12111L MS31 trihydrochloride (2366264-12-0 free base) T12111L 99.88%
MS31 trihydrochloride (2366264-12-0 free base)
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor....
T16154 MS417 916489-36-6 99.88%
MS417
MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivit...
T60032 BRM/BRG1 ATP Inhibitor-2 2368900-77-8 99.88%
BRM/BRG1 ATP Inhibitor-2
BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.
CBP/p300-IN-5
T12346
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
YHO-13351
T13366
YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
NHWD-870
T36573
NHWD-870 is an effective and selective inhibitor of BET family bromodomain only binding to BRD2, BRD3, BRD4 (IC50 = 2.7 nM), and BRDT. NHWD-870 exhibits potent a...
GNE-272
T15400
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
BRD4 degrader AT1
T5439
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
IACS-9571 Hydrochloride (1800477-30-8 free base)
T11597L
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
GNE-987
T11441
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
MI-503
TQ0069
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
Cycloastragenol
T5575
Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus m...
ZL0590
T60072
ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.
Birabresib
T6032
Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 wi...
AW68
T10638L
AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.
GNE-781
T15405
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, re...
PF-CBP1
T3973
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 36...
CPI-637
T6811
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
BAZ1A-IN-1
T9552
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell l...
PBRM1-BD2-IN-3
T60158
PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.
MS31 trihydrochloride (2366264-12-0 free base)
T12111L
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor....
MS417
T16154
MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivit...
BRM/BRG1 ATP Inhibitor-2
T60032
BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.
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TargetMol