T12346 |
CBP/p300-IN-5
|
1889284-33-6
|
98%
|
|
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
|
T13366 |
YHO-13351
|
1346753-00-1
|
98%
|
|
YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
|
T36573 |
NHWD-870
|
2115742-03-3
|
98%
|
|
NHWD-870 is an effective and selective inhibitor of BET family bromodomain only binding to BRD2, BRD3, BRD4 (IC50 = 2.7 nM), and BRDT. NHWD-870 exhibits potent a...
|
T15400 |
GNE-272
|
1936428-93-1
|
98%
|
|
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
|
T5439 |
BRD4 degrader AT1
|
2098836-45-2
|
98%
|
|
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
|
T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
|
T11597L
|
98%
|
|
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
|
T11441 |
GNE-987
|
2417371-71-0
|
98%
|
|
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
|
TQ0069 |
MI-503
|
1857417-13-0
|
99.99%
|
|
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
|
T5575 |
Cycloastragenol
|
78574-94-4
|
99.98%
|
|
Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus m...
|
T60072 |
ZL0590
|
2230496-99-6
|
99.95%
|
|
ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.
|
T6032 |
Birabresib
|
202590-98-5
|
99.93%
|
|
Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 wi...
|
T10638L |
AW68
|
2247236-61-7
|
99.92%
|
|
AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.
|
T15405 |
GNE-781
|
1936422-33-1
|
99.92%
|
|
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, re...
|
T3973 |
PF-CBP1
|
1962928-21-7
|
99.91%
|
|
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 36...
|
T6811 |
CPI-637
|
1884712-47-3
|
99.91%
|
|
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
|
T9552 |
BAZ1A-IN-1
|
941521-45-5
|
99.91%
|
|
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell l...
|
T60158 |
PBRM1-BD2-IN-3
|
2819989-58-5
|
99.91%
|
|
PBRM1-BD2-IN-3 (compound 12) is a potent inhibitor of PBRM1-BD2, exhibiting an IC50 value of 1.1 μM, and is utilized in anticancer research.
|
T12111L |
MS31 trihydrochloride (2366264-12-0 free base)
|
T12111L
|
99.88%
|
|
MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor....
|
T16154 |
MS417
|
916489-36-6
|
99.88%
|
|
MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivit...
|
T60032 |
BRM/BRG1 ATP Inhibitor-2
|
2368900-77-8
|
99.88%
|
|
BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.
|