Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product name	CAS No.	Purity
T2442	CPI203	202591-23-9	99.71%
T2442	CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5435	ARV-771	1949837-12-0	99.69%
T5435	ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
T10616	BRM/BRG1 ATP Inhibitor-1	2270879-17-7	99.68%
T10616	BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2...
T6026	CPI-203	1446144-04-2	99.66%
T6026	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T10641	C-82	1422253-37-9	99.66%
T10641	C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T6255	Bromosporine	1619994-69-2	99.65%
T6255	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T8890	653-47 hydrochloride	1224567-46-7	99.65%
T8890	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a ver...
T1993	J-147	1146963-51-0	99.61%
T1993	J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T11925	M‑89	2363165-42-6	99.58%
T11925	M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin bindi...
T5417	INCB-057643	1820889-23-3	99.58%
T5417	INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
T60159	PBRM1-BD2-IN-5	2819989-61-0	99.55%
T60159	PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, ...
T6113	ICG-001	780757-88-2	99.55%
T6113	ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
T5440	Dbet57	1883863-52-2	99.52%
T5440	dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive ...
T2436	GSK2801	1619994-68-1	99.5%
T2436	GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T60157	PBRM1-BD2-IN-8	2819989-75-6	99.48%
T60157	PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti...
T12551	PROTAC BRD4 ligand-1	2313230-51-0	99.48%
T12551	PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T64117	BRD4-BD1-IN-2	2761321-26-8	99.47%
T64117	BRD4-BD1-IN-2 is a selective and potent BRD4-BD1 inhibitor with an IC50 value of 2.51 µM, which is 20-fold greater than the inhibitory activity against BRD4-BD2....
T0808	Diflunisal	22494-42-4	99.42%
T0808	Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
T10638	BY27	2247236-59-3	99.40%
T10638	BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growt...
T5443	JQ-1 (carboxylic acid)	202592-23-2	99.39%
T5443	JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)