Home Tools
Log in
Cart

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16321 NI-42 1884640-99-6 99.17%
NI-42
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
T69742 SRX3177 2241237-51-2 99.16%
SRX3177
SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
T6809 CPI-169 racemate 1450655-76-1 99.14%
CPI-169 racemate
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T6584 MG 149 1243583-85-8 99.1%
MG 149
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969 I-CBP112 1640282-31-0 99.1%
I-CBP112
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T13392 ZEN-3219 1952264-34-4 99.06%
ZEN-3219
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values o...
T36395 Trotabresib 1706738-98-8 99.03%
Trotabresib
Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
T2120 I-BET151 1300031-49-5 99.03%
I-BET151
I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T6668 SGC-CBP30 1613695-14-9 99.03%
SGC-CBP30
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T13890 SMARCA-BD ligand 1 for Protac dihydrochloride 2369053-68-7 99.01%
SMARCA-BD ligand 1 for Protac dihydrochloride
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T11136 E-7386 1799824-08-0 99%
E-7386
E-7386 is an oral active CBP/ -catenin modulator.
T14776 BRD4 Inhibitor-10 1660117-38-3 98.98%
BRD4 Inhibitor-10
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T31224 Piflufolastat 1423758-00-2 98.98%
Piflufolastat
Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA. It is a fluorinated prostate-specific membrane antigen (PSMA) preparation. Piflufolastat ...
T1516 Curcumin 458-37-7 98.98%
Curcumin
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
T5425 ML367 381168-77-0 98.97%
ML367
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitor...
T5362 Y06036 1832671-96-1 98.95%
Y06036
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T9399 Menin-MLL inhibitor 20 2448173-47-3 98.89%
Menin-MLL inhibitor 20
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.
T2379 UNC1215 1415800-43-9 98.87%
UNC1215
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
T8495 Alobresib 1637771-14-2 98.87%
Alobresib
Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
T12338 OXFBD04 2231747-03-6 98.84%
OXFBD04
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBB...
NI-42
T16321
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
SRX3177
T69742
SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
CPI-169 racemate
T6809
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
MG 149
T6584
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
I-CBP112
T3969
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
ZEN-3219
T13392
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values o...
Trotabresib
T36395
Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
I-BET151
T2120
I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
SGC-CBP30
T6668
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
SMARCA-BD ligand 1 for Protac dihydrochloride
T13890
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
E-7386
T11136
E-7386 is an oral active CBP/ -catenin modulator.
BRD4 Inhibitor-10
T14776
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
Piflufolastat
T31224
Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA. It is a fluorinated prostate-specific membrane antigen (PSMA) preparation. Piflufolastat ...
Curcumin
T1516
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
ML367
T5425
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitor...
Y06036
T5362
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
Menin-MLL inhibitor 20
T9399
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.
UNC1215
T2379
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
Alobresib
T8495
Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
OXFBD04
T12338
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBB...
1 2 3 4 5 6 7 8 9 10 11 12 13 14
TargetMol