T16321 |
NI-42
|
1884640-99-6
|
99.17%
|
|
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
|
T69742 |
SRX3177
|
2241237-51-2
|
99.16%
|
|
SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
|
T6809 |
CPI-169 racemate
|
1450655-76-1
|
99.14%
|
|
CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
|
T6584 |
MG 149
|
1243583-85-8
|
99.1%
|
|
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
|
T3969 |
I-CBP112
|
1640282-31-0
|
99.1%
|
|
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
|
T13392 |
ZEN-3219
|
1952264-34-4
|
99.06%
|
|
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values o...
|
T36395 |
Trotabresib
|
1706738-98-8
|
99.03%
|
|
Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
|
T2120 |
I-BET151
|
1300031-49-5
|
99.03%
|
|
I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
|
T6668 |
SGC-CBP30
|
1613695-14-9
|
99.03%
|
|
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
|
T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
|
2369053-68-7
|
99.01%
|
|
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
|
T11136 |
E-7386
|
1799824-08-0
|
99%
|
|
E-7386 is an oral active CBP/ -catenin modulator.
|
T14776 |
BRD4 Inhibitor-10
|
1660117-38-3
|
98.98%
|
|
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
|
T31224 |
Piflufolastat
|
1423758-00-2
|
98.98%
|
|
Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA. It is a fluorinated prostate-specific membrane antigen (PSMA) preparation. Piflufolastat ...
|
T1516 |
Curcumin
|
458-37-7
|
98.98%
|
|
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
|
T5425 |
ML367
|
381168-77-0
|
98.97%
|
|
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitor...
|
T5362 |
Y06036
|
1832671-96-1
|
98.95%
|
|
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
|
T9399 |
Menin-MLL inhibitor 20
|
2448173-47-3
|
98.89%
|
|
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.
|
T2379 |
UNC1215
|
1415800-43-9
|
98.87%
|
|
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
|
T8495 |
Alobresib
|
1637771-14-2
|
98.87%
|
|
Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
|
T12338 |
OXFBD04
|
2231747-03-6
|
98.84%
|
|
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBB...
|