T0035 |
Dienestrol |
Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and ...
|
T0040 |
Quinestrol |
Quinestrol is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment. |
T0139 |
Toremifene |
Toremifene is a selective estrogen-receptor modulator (SERM). |
T0168 |
Depofemin |
Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor. |
T0171 |
Norethynodrel |
Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uter...
|
T0188 |
Fluticasone propionate |
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
|
T0301 |
Ethisterone |
Ethisterone is a progestogen hormone. |
T0345 |
Estropipate |
Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine. |
T0384 |
Estradiol benzoate |
Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristic...
|
T0478 |
Progesterone |
Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY ...
|
T0593 |
XCT790 |
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα). |
T0709 |
Pimaricin |
Natamycin is a Polyene Antimicrobial. |
T0835 |
Tamoxifen Z-isomer citrate |
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). |
T0870 |
Altrenogest |
Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone. |
T0996 |
Ethynodiol diacetate |
Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. |
T1009 |
Aquacrine |
Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from...
|
T1048 |
Estradiol |
Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist. |
T1102 |
Mifepristone |
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist. |
T1193 |
Clomifene citrate |
Clomifene Citrate is a selective estrogen receptor modulator. |
T1216 |
Diethylstilbestrol |
Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders. |
T1261 |
Medroxyprogesterone Acetate |
Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orall...
|
T1263 |
Levonorgestrel |
Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. |
T1284 |
Megestrol acetate |
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
|
T1377 |
Methyldienedione |
Methyldienedione is an anabolic steroid and a precursor to dienolone. |
T1424 |
Ethynyl estradiol |
Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is o...
|
T1429 |
Hydroxyprogesterone |
Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimeste...
|
T1438 |
Butoconazole nitrate |
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes wit...
|
T1464 |
Toremifene citrate |
Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic o...
|
T1480 |
Danazol |
Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
|
T1490 |
Gestodene |
Gestodene is a progestogen hormonal contraceptive. |
T1514 |
Norethindrone |
Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It ha...
|
T1536 |
Promestriene |
Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic. |
T1541 |
Drospirenone |
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. |
T1549 |
Raloxifene hydrochloride |
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrog...
|
T1571 |
Estriol |
Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estroge...
|
T1579 |
Mestranol |
Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active. |
T1659 |
Melatonine |
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
|
T1688 |
5Beta-Pregnane-3Alpha,20alpha-Diol |
5Beta-Pregnane-3Alpha, 20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at...
|
T2146 |
FulvestrantHOT |
Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM). |
T2177 |
Kaempferol |
Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. |
T2195 |
Epiandrosterone |
Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. |
T2231 |
17-Beta-Estradiol-3,17-Dipropionate |
Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol. |
T2250 |
DY131 |
DY131 is a novel selective agonist of ERRβ and ERRγ. |
T2280 |
Endoxifen Z-isomer |
Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. |
T2527 |
Ulipristal acetate |
Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Uliprista...
|
T2544 |
Bazedoxifene acetate |
Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM). |
T2559 |
Allylestrenol |
Allylestrenol is a synthetic steroid with progestational activity. |
T2567 |
Etonogestrel |
Etonogestrel is a steroidal progestin used as hormonal contraceptives. |
T2569 |
Chlorotrianisene |
Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wi...
|
T2577 |
Dienogest |
Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antian...
|
T2597 |
Norgestrel |
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing...
|
T2598 |
Thymopentin |
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
|
T2973 |
Astragaloside IV |
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
|
T3325 |
Liquiritigenin |
Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. |
T3378 |
17α-Estradiol |
Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively). |
T3645 |
Endoxifen E-isomer hydrochloride |
Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM). |
T3717 |
β-thujaplicin |
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
|
T3806 |
kaempferide |
Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
|
T3846 |
Bavachin |
Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ. |
T3958 |
WAY 200070 |
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM). |
T3975 |
AZD9496 |
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity. |
T4000 |
(±)-Equol |
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
|
T6306 |
Erteberel |
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. |
T6404 |
Bazedoxifene HCl |
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respecti...
|
T6491 |
Equol |
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
|
T6533 |
Hexestrol |
Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
T6620 |
Ospemifene |
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
|
T6683 |
STF62247 |
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. |
T6713 |
Ulipristal |
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. |
T6819 |
Desogestrel |
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. |
T6827 |
Endoxifen HCl |
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist. |
T6906 |
Tamoxifen |
Tamoxifen is an antagonist of the estrogen receptor in breast tissue. |
T4281 |
(E/Z)-Endoxifen |
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-...
|
T4388 |
PHTPP |
PHTPP is a selective ERβ antagonist. |
T4420 |
(Z)-4-hydroxy Tamoxifen |
4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). |
T4549 |
Tibolone |
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
|
T5118 |
GDC0810 |
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM). |
T5174 |
Nestoron |
Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM). |
T5531 |
GSK-4716 |
GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand |
T5633 |
H3B-5942 |
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). |
T5835 |
PROTAC ERRα ligand 2 |
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM) |
T7223 |
Gestrinone |
Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
|
T7644 |
DPN |
DPN is an selective agonist of estrogen receptor β (ERβ) . |
TQ0149 |
Prinaberel |
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ. |
TQ0163 |
Sagittatoside A |
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα. |
T7839 |
Lasofoxifene Tartrate |
Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator. |
TQ0274 |
25(R)-27-hydroxy Cholesterol |
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
T3399 |
Psoralidin |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
|
T7974 |
Lynestrenol |
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist |
TN1052 |
Lindleyin |
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens. |
TN1148 |
Isopsoralenoside |
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects. |
TN1679 |
Genistein 7,4'-di-O-beta-D-glucopyranoside |
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. |
TN1768 |
Iriflophenone |
Standard reference |
TN2200 |
Segetalin A |
Segetalin A has estrogen-like activity. |
TN1370 |
Allura Red AC |
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries. |
TN1690 |
Glabrene |
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
|
TN2045 |
Pelargonidin-3-O-glucoside chloride |
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
|
TN2288 |
Uralenol |
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
|
T8370 |
GSK5182 |
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM) |
T12278 |
NXT629 |
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM). |
T12312 |
OP-1074 |
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ. |
T12329 |
Ospemifene D4 |
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor. |
T14987 |
CMP8 |
CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and...
|
T15191 |
PROTAC ERRα ligand 1 |
PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ). |
T13674 |
Elacestrant |
Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . |
T13675 |
Elacestrant dihydrochloride |
Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively. |
T11222 |
ERB-196 |
Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity. |
T11230 |
ERRα antagonist-1 |
ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα...
|
T11231 |
ERRγ Inverse Agonist 1 |
ERRγ Inverse Agonist 1 is a potent, selective and orally bioavailable Estrogen-related Receptor grammar inverse agonist, with an IC50 of 40 nM. |
T11399 |
Giredestrant |
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ...
|
T13447 |
(R)-Zanubrutinib |
(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK). |
T16351 |
NSC16168 |
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM). |
T13768 |
(+)-Medicarpin |
(+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...
|
T12832 |
SAR439859 |
SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM f...
|
T4505 |
Ferrous Bisglycinate |
Ferrous Bisglycinate is used in the fortification of infant formulations and foods. |
T2810 |
(20S)-Protopanaxatriol |
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. |
T7904 |
SR 19881 |
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay). |
T7709 |
(E/Z)-GSK5182 |
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ)...
|
T6743 |
4-Hydroxytamoxifen |
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreven...
|
T5040 |
Medroxyprogesterone |
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. |