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Endocrinology/Hormones Estrogen/progestogen Receptor

Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
Cat No. product name
T0035 Dienestrol Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and ...
T0040 Quinestrol Quinestrol  is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T0139 Toremifene Toremifene is a selective estrogen-receptor modulator (SERM).
T0168 Depofemin Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
T0301 Ethisterone Ethisterone is a progestogen hormone.
T0345 Estropipate Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
T0384 Estradiol benzoate Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristic...
T0478 Progesterone Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY ...
T0593 XCT790 XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T0709 Pimaricin Natamycin is a Polyene Antimicrobial.
T0835 Tamoxifen Z-isomer citrate Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T0870 Altrenogest Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
T0996 Ethynodiol diacetate Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
T1009 Aquacrine Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from...
T1048 Estradiol Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1193 Clomifene citrate Clomifene Citrate is a selective estrogen receptor modulator.
T1216 Diethylstilbestrol Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
T1261 Farlutin Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orall...
T1263 Levonorgestrel Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
T1284 Megestrol acetate Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
T1377 Methyldienedione Methyldienedione is an anabolic steroid and a precursor to dienolone.
T1424 Ethynyl estradiol Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is o...
T1429 Hydroxyprogesterone Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimeste...
T1438 Butoconazole nitrate Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes wit...
T1464 Toremifene citrate Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic ...
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
T1490 Gestodene Gestodene is a progestogen hormonal contraceptive.
T1514 Norethindrone Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It ha...
T1536 Promestriene Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1549 Raloxifene hydrochloride Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrog...
T1571 Estriol Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estroge...
T1579 Mestranol Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T1659 Melatonin Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T1688 5Beta-Pregnane-3Alpha,20alpha-Diol 5Beta-Pregnane-3Alpha,20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at ...
T2146 FulvestrantHOT Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
T2177 Kaempferol Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2231 17-Beta-Estradiol-3,17-Dipropionate Estradiol dipropionate is a synthetic ester, specifically the 3,17-dipropanoyl ester, of the natural estrogen, estradiol.
T2250 DY-131 DY131 is a novel selective agonist of ERRβ and ERRγ.
T2280 Endoxifen Z-isomer Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T2527 Ulipristal acetate Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Uliprista...
T2544 Bazedoxifene acetate Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
T2559 Allylestrenol Allylestrenol is a synthetic steroid with progestational activity.
T2567 Etonogestrel Etonogestrel is a steroidal progestin used as hormonal contraceptives.
T2569 Chlorotrianisene Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wi...
T2577 Dienogest Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antian...
T2597 Norgestrel Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing...
T2598 Thymopentin Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
T2973 Astragaloside IV Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
T3325 Liquiritigenin Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3378 17α-Estradiol Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
T3645 Endoxifen E-isomer hydrochloride Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
T3717 β-thujaplicin β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
T3806 kaempferide Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
T3846 Bavachin Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T3958 WAY 200070 WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T3975 AZD9496 AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
T6404 Bazedoxifene HCl Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respect...
T6491 Equol S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
T6533 Hexestrol Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T6620 Ospemifene Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
T6683 STF-62247 STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells,respectively.
T6713 Ulipristal Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T6819 Desogestrel Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T6827 Endoxifen HCl Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T6906 Tamoxifen Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
T4281 (E/Z)-Endoxifen Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T4388 PHTPP PHTPP is a selective Erβ antagonist.
T4420 (Z)-4-hydroxy Tamoxifen <p>Afimoxifene, a tamoxifen metabolite, is estrogen receptor antagonist (IC50: 3.3 nM). It also increases CRISPR/Cas9-mediated editing frequency.</p>
T4549 Tibolone Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
T5118 GDC-0810 GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
T5174 Nestoron Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
T5531 GSK-4716 GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand
T5633 H3B-5942 H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T5835 PROTAC ERRα ligand 2 PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T7223 Gestrinone Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
T7644 DPN DPN is an selective agonist of estrogen receptor β (ERβ) .
TQ0149 Prinaberel Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
TQ0163 Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T7839 Lasofoxifene Tartrate Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
TQ0274 25(R)-27-hydroxy Cholesterol 27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T3399 Psoralidin Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
T7974 Lynestrenol Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
TN1052 Lindleyin Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
TN1148 Isopsoralenoside Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
TN1679 Genistein 7,4'-di-O-beta-D-glucopyranoside Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
TN1768 Iriflophenone Standard reference
TN2200 Segetalin A Segetalin A has estrogen-like activity.
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1690 Glabrene Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
TN2045 Pelargonidin-3-O-glucoside chloride Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
TN2288 Uralenol Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
T8370 GSK5182 GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T12278 NXT629 NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
T12312 OP-1074 OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
T12329 Ospemifene D4 Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T14987 CMP8 CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and...
T15191 PROTAC ERRα ligand 1 PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
T13674 Elacestrant  Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
T13675 Elacestrant dihydrochloride Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
T11222 ERB-196 Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
T11230 ERRα antagonist-1 ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα...
T11231 ERRγ Inverse Agonist 1 ERRγ Inverse Agonist 1  is a potent, selective and orally bioavailable Estrogen-related Receptor grammar  inverse agonist, with an IC50 of 40 nM. 
T11399 Giredestrant Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ...
T13447 (R)-Zanubrutinib (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
T16351 NSC16168 NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T13768 (+)-Medicarpin (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...
Dienestrol
T0035CAS 84-17-3
Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and ...
Quinestrol
T0040CAS 152-43-2
Quinestrol  is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
Toremifene
T0139CAS 89778-26-7
Toremifene is a selective estrogen-receptor modulator (SERM).
Depofemin
T0168CAS 313-06-4
Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
Fluticasone propionate
T0188CAS 80474-14-2
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
Ethisterone
T0301CAS 434-03-7
Ethisterone is a progestogen hormone.
Estropipate
T0345CAS 7280-37-7
Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
Estradiol benzoate
T0384CAS 50-50-0
Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristic...
Progesterone
T0478CAS 57-83-0
Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY ...
XCT790
T0593CAS 725247-18-7
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
Pimaricin
T0709CAS 7681-93-8
Natamycin is a Polyene Antimicrobial.
Tamoxifen Z-isomer citrate
T0835CAS 54965-24-1
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
Altrenogest
T0870CAS 850-52-2
Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
Ethynodiol diacetate
T0996CAS 297-76-7
Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Aquacrine
T1009CAS 53-16-7
Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from...
Estradiol
T1048CAS 50-28-2
Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
Mifepristone
T1102CAS 84371-65-3
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Clomifene citrate
T1193CAS 50-41-9
Clomifene Citrate is a selective estrogen receptor modulator.
Diethylstilbestrol
T1216CAS 56-53-1
Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
Farlutin
T1261CAS 71-58-9
Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orall...
Levonorgestrel
T1263CAS 797-63-7
Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
Megestrol acetate
T1284CAS 595-33-5
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
Methyldienedione
T1377CAS 5173-46-6
Methyldienedione is an anabolic steroid and a precursor to dienolone.
Ethynyl estradiol
T1424CAS 57-63-6
Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is o...
Hydroxyprogesterone
T1429CAS 68-96-2
Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimeste...
Butoconazole nitrate
T1438CAS 64872-77-1
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes wit...
Toremifene citrate
T1464CAS 89778-27-8
Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic ...
Danazol
T1480CAS 17230-88-5
Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
Gestodene
T1490CAS 60282-87-3
Gestodene is a progestogen hormonal contraceptive.
Norethindrone
T1514CAS 68-22-4
Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It ha...
Promestriene
T1536CAS 39219-28-8
Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Raloxifene hydrochloride
T1549CAS 82640-04-8
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrog...
Estriol
T1571CAS 50-27-1
Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estroge...
Mestranol
T1579CAS 72-33-3
Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
Melatonin
T1659CAS 73-31-4
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
5Beta-Pregnane-3Alpha,20alpha-Diol
T1688CAS 80-92-2
5Beta-Pregnane-3Alpha,20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at ...
Fulvestrant HOT
T2146CAS 129453-61-8
Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
Kaempferol
T2177CAS 520-18-3
Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
Epiandrosterone
T2195CAS 481-29-8
Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
17-Beta-Estradiol-3,17-Dipropionate
T2231CAS 113-38-2
Estradiol dipropionate is a synthetic ester, specifically the 3,17-dipropanoyl ester, of the natural estrogen, estradiol.
DY-131
T2250CAS 95167-41-2
DY131 is a novel selective agonist of ERRβ and ERRγ.
Endoxifen Z-isomer
T2280CAS 112093-28-4
Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
Ulipristal acetate
T2527CAS 126784-99-4
Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Uliprista...
Bazedoxifene acetate
T2544CAS 198481-33-3
Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
Allylestrenol
T2559CAS 432-60-0
Allylestrenol is a synthetic steroid with progestational activity.
Etonogestrel
T2567CAS 54048-10-1
Etonogestrel is a steroidal progestin used as hormonal contraceptives.
Chlorotrianisene
T2569CAS 569-57-3
Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wi...
Dienogest
T2577CAS 65928-58-7
Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antian...
Norgestrel
T2597CAS 6533-00-2
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing...
Thymopentin
T2598CAS 69558-55-0
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
Astragaloside IV
T2973CAS 84687-43-4
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
Liquiritigenin
T3325CAS 578-86-9
Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
17α-Estradiol
T3378CAS 57-91-0
Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
Endoxifen E-isomer hydrochloride
T3645CAS 1197194-61-8
Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
β-thujaplicin
T3717CAS 499-44-5
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
kaempferide
T3806CAS 491-54-3
Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
Bavachin
T3846CAS 19879-32-4
Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
WAY 200070
T3958CAS 440122-66-7
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
AZD9496
T3975CAS 1639042-08-2
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
(±)-Equol
T4000CAS 94105-90-5
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
Bazedoxifene HCl
T6404CAS 198480-56-7
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respect...
Equol
T6491CAS 531-95-3
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
Hexestrol
T6533CAS 84-16-2
Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Ospemifene
T6620CAS 128607-22-7
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
STF-62247
T6683CAS 315702-99-9
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells,respectively.
Ulipristal
T6713CAS 159811-51-5
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
Desogestrel
T6819CAS 54024-22-5
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Endoxifen HCl
T6827CAS 1032008-74-4
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Tamoxifen
T6906CAS 10540-29-1
Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
(E/Z)-Endoxifen
T4281CAS 110025-28-0
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
PHTPP
T4388CAS 805239-56-9
PHTPP is a selective Erβ antagonist.
(Z)-4-hydroxy Tamoxifen
T4420CAS 68047-06-3
<p>Afimoxifene, a tamoxifen metabolite, is estrogen receptor antagonist (IC50: 3.3 nM). It also increases CRISPR/Cas9-mediated editing frequency.</p>
Tibolone
T4549CAS 5630-53-5
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
GDC-0810
T5118CAS 1365888-06-7
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
Nestoron
T5174CAS 7759-35-5
Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
GSK-4716
T5531CAS 101574-65-6
GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand
H3B-5942
T5633CAS 2052128-15-9
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
PROTAC ERRα ligand 2
T5835CAS 2306388-57-6
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
Gestrinone
T7223CAS 16320-04-0
Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
DPN
T7644CAS 1428-67-7
DPN is an selective agonist of estrogen receptor β (ERβ) .
Prinaberel
TQ0149CAS 524684-52-4
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
Sagittatoside A
TQ0163CAS 118525-35-2
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
Lasofoxifene Tartrate
T7839CAS 190791-29-8
Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
25(R)-27-hydroxy Cholesterol
TQ0274CAS 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Psoralidin
T3399CAS 18642-23-4
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
Lynestrenol
T7974CAS 52-76-6
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
Lindleyin
TN1052CAS 59282-56-3
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Isopsoralenoside
TN1148CAS 905954-18-9
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
Genistein 7,4'-di-O-beta-D-glucopyranoside
TN1679CAS 36190-98-4
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
Iriflophenone
TN1768CAS 52591-10-3
Standard reference
Segetalin A
TN2200CAS 161875-97-4
Segetalin A has estrogen-like activity.
Allura Red AC
TN1370CAS 25956-17-6
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
Glabrene
TN1690CAS 60008-03-9
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
Pelargonidin-3-O-glucoside chloride
TN2045CAS 18466-51-8
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
Uralenol
TN2288CAS 139163-15-8
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
GSK5182
T8370CAS 877387-37-6
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
NXT629
T12278CAS 1454925-59-7
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
OP-1074
T12312CAS 1443752-76-8
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Ospemifene D4
T12329CAS T12329
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
CMP8
T14987CAS 851107-28-3
CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and...
PROTAC ERRα ligand 1
T15191CAS 1264754-13-3
PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
Elacestrant
T13674CAS 722533-56-4
 Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
Elacestrant dihydrochloride
T13675CAS 1349723-93-8
Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
ERB-196
T11222CAS 550997-55-2
Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
ERRα antagonist-1
T11230CAS 1072145-33-5
ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα...
ERRγ Inverse Agonist 1
T11231CAS T11231
ERRγ Inverse Agonist 1  is a potent, selective and orally bioavailable Estrogen-related Receptor grammar  inverse agonist, with an IC50 of 40 nM. 
Giredestrant
T11399CAS 1953133-47-5
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ...
(R)-Zanubrutinib
T13447CAS 1691249-44-1
(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
NSC16168
T16351CAS 6837-93-0
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
(+)-Medicarpin
T13768CAS 33983-39-0
(+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...