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Endocrinology/Hormones Estrogen/progestogen Receptor

Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
Cat No. Product Name
T2598 Thymopentin Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
T2973 Astragaloside IV Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
T3325 Liquiritigenin Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3378 17α-Estradiol Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
T3645 Endoxifen E-isomer hydrochloride Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
T3717 β-thujaplicin β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
T3806 kaempferide Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
T3846 Bavachin Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T3958 WAY 200070 WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T3975 AZD9496 AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
T6404 Bazedoxifene HCl Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respect...
T6491 Equol S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
T6533 Hexestrol Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T6620 Ospemifene Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
T6683 STF-62247 STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells,respectively.
T6713 Ulipristal Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T6819 Desogestrel Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T6827 Endoxifen HCl Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T6906 Tamoxifen Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
T4281 (E/Z)-Endoxifen Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T4388 PHTPP PHTPP is a selective Erβ antagonist.
T4420 (Z)-4-hydroxy Tamoxifen <p>Afimoxifene, a tamoxifen metabolite, is estrogen receptor antagonist (IC50: 3.3 nM). It also increases CRISPR/Cas9-mediated editing frequency.</p>
T4549 Tibolone Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
T5118 GDC-0810 GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
T5174 Nestoron Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
T5531 GSK-4716 GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand
T5633 H3B-5942 H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T5835 PROTAC ERRα ligand 2 PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T7223 Gestrinone Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
T7644 DPN DPN is an selective agonist of estrogen receptor β (ERβ) .
TQ0149 Prinaberel Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
TQ0163 Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T7839 Lasofoxifene Tartrate Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
TQ0274 25(R)-27-hydroxy Cholesterol 27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T3399 Psoralidin Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
T7974 Lynestrenol Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
TN1052 Lindleyin Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
TN1148 Isopsoralenoside Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
TN1679 Genistein 7,4'-di-O-beta-D-glucopyranoside Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
TN1768 Iriflophenone Standard reference
TN2200 Segetalin A Segetalin A has estrogen-like activity.
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1690 Glabrene Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
TN2045 Pelargonidin-3-O-glucoside chloride Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
TN2288 Uralenol Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
T8370 GSK5182 GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T12278 NXT629 NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
T12312 OP-1074 OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
T12329 Ospemifene D4 Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
Thymopentin
T2598CAS 69558-55-0
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
Astragaloside IV
T2973CAS 84687-43-4
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
Liquiritigenin
T3325CAS 578-86-9
Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
17α-Estradiol
T3378CAS 57-91-0
Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
Endoxifen E-isomer hydrochloride
T3645CAS 1197194-61-8
Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
β-thujaplicin
T3717CAS 499-44-5
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
kaempferide
T3806CAS 491-54-3
Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
Bavachin
T3846CAS 19879-32-4
Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
WAY 200070
T3958CAS 440122-66-7
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
AZD9496
T3975CAS 1639042-08-2
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
(±)-Equol
T4000CAS 94105-90-5
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
Bazedoxifene HCl
T6404CAS 198480-56-7
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respect...
Equol
T6491CAS 531-95-3
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
Hexestrol
T6533CAS 84-16-2
Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Ospemifene
T6620CAS 128607-22-7
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
STF-62247
T6683CAS 315702-99-9
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells,respectively.
Ulipristal
T6713CAS 159811-51-5
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
Desogestrel
T6819CAS 54024-22-5
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Endoxifen HCl
T6827CAS 1032008-74-4
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Tamoxifen
T6906CAS 10540-29-1
Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
(E/Z)-Endoxifen
T4281CAS 110025-28-0
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
PHTPP
T4388CAS 805239-56-9
PHTPP is a selective Erβ antagonist.
(Z)-4-hydroxy Tamoxifen
T4420CAS 68047-06-3
<p>Afimoxifene, a tamoxifen metabolite, is estrogen receptor antagonist (IC50: 3.3 nM). It also increases CRISPR/Cas9-mediated editing frequency.</p>
Tibolone
T4549CAS 5630-53-5
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
GDC-0810
T5118CAS 1365888-06-7
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
Nestoron
T5174CAS 7759-35-5
Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
GSK-4716
T5531CAS 101574-65-6
GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand
H3B-5942
T5633CAS 2052128-15-9
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
PROTAC ERRα ligand 2
T5835CAS 2306388-57-6
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
Gestrinone
T7223CAS 16320-04-0
Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
DPN
T7644CAS 1428-67-7
DPN is an selective agonist of estrogen receptor β (ERβ) .
Prinaberel
TQ0149CAS 524684-52-4
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
Sagittatoside A
TQ0163CAS 118525-35-2
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
Lasofoxifene Tartrate
T7839CAS 190791-29-8
Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
25(R)-27-hydroxy Cholesterol
TQ0274CAS 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Psoralidin
T3399CAS 18642-23-4
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
Lynestrenol
T7974CAS 52-76-6
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
Lindleyin
TN1052CAS 59282-56-3
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Isopsoralenoside
TN1148CAS 905954-18-9
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
Genistein 7,4'-di-O-beta-D-glucopyranoside
TN1679CAS 36190-98-4
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
Iriflophenone
TN1768CAS 52591-10-3
Standard reference
Segetalin A
TN2200CAS 161875-97-4
Segetalin A has estrogen-like activity.
Allura Red AC
TN1370CAS 25956-17-6
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
Glabrene
TN1690CAS 60008-03-9
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
Pelargonidin-3-O-glucoside chloride
TN2045CAS 18466-51-8
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
Uralenol
TN2288CAS 139163-15-8
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
GSK5182
T8370CAS 877387-37-6
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
NXT629
T12278CAS 1454925-59-7
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
OP-1074
T12312CAS 1443752-76-8
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Ospemifene D4
T12329CAS
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.