Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.

Cat No.	product name
T0035	Dienestrol	Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and ...
T0040	Quinestrol	Quinestrol is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T0139	Toremifene	Toremifene is a selective estrogen-receptor modulator (SERM).
T0168	Depofemin	Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T0171	Norethynodrel	Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uter...
T0188	Fluticasone propionate	Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
T0301	Ethisterone	Ethisterone is a progestogen hormone.
T0345	Estropipate	Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
T0384	Estradiol benzoate	Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristic...
T0478	Progesterone	Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY ...
T0593	XCT790	XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T0709	Pimaricin	Natamycin is a Polyene Antimicrobial.
T0835	Tamoxifen Z-isomer citrate	Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T0870	Altrenogest	Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
T0996	Ethynodiol diacetate	Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
T1009	Aquacrine	Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from...
T1048	Estradiol	Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
T1102	Mifepristone	Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1193	Clomifene citrate	Clomifene Citrate is a selective estrogen receptor modulator.
T1216	Diethylstilbestrol	Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
T1261	Medroxyprogesterone Acetate	Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orall...
T1263	Levonorgestrel	Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
T1284	Megestrol acetate	Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
T1377	Methyldienedione	Methyldienedione is an anabolic steroid and a precursor to dienolone.
T1424	Ethynyl estradiol	Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is o...
T1429	Hydroxyprogesterone	Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimeste...
T1438	Butoconazole nitrate	Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes wit...
T1464	Toremifene citrate	Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic o...
T1480	Danazol	Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
T1490	Gestodene	Gestodene is a progestogen hormonal contraceptive.
T1514	Norethindrone	Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It ha...
T1536	Promestriene	Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
T1541	Drospirenone	Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1549	Raloxifene hydrochloride	Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrog...
T1571	Estriol	Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estroge...
T1579	Mestranol	Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T1659	Melatonine	Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T1688	5Beta-Pregnane-3Alpha,20alpha-Diol	5Beta-Pregnane-3Alpha, 20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at...
T2146	FulvestrantHOT	Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
T2177	Kaempferol	Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T2195	Epiandrosterone	Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2231	17-Beta-Estradiol-3,17-Dipropionate	Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
T2250	DY131	DY131 is a novel selective agonist of ERRβ and ERRγ.
T2280	Endoxifen Z-isomer	Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T2527	Ulipristal acetate	Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Uliprista...
T2544	Bazedoxifene acetate	Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
T2559	Allylestrenol	Allylestrenol is a synthetic steroid with progestational activity.
T2567	Etonogestrel	Etonogestrel is a steroidal progestin used as hormonal contraceptives.
T2569	Chlorotrianisene	Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wi...
T2577	Dienogest	Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antian...
T2597	Norgestrel	Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing...
T2598	Thymopentin	Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is...
T2973	Astragaloside IV	Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloprotea...
T3325	Liquiritigenin	Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3378	17α-Estradiol	Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
T3645	Endoxifen E-isomer hydrochloride	Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
T3717	β-thujaplicin	β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activit...
T3806	kaempferide	Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by l...
T3846	Bavachin	Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T3958	WAY 200070	WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T3975	AZD9496	AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T4000	(±)-Equol	Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor ...
T6306	Erteberel	LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T6404	Bazedoxifene HCl	Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respecti...
T6491	Equol	S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with...
T6533	Hexestrol	Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T6620	Ospemifene	Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vul...
T6683	STF62247	STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.
T6713	Ulipristal	Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T6819	Desogestrel	Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T6827	Endoxifen HCl	Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T6906	Tamoxifen	Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
T4281	(E/Z)-Endoxifen	(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-...
T4388	PHTPP	PHTPP is a selective ERβ antagonist.
T4420	(Z)-4-hydroxy Tamoxifen	4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
T4549	Tibolone	Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the...
T5118	GDC0810	GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
T5174	Nestoron	Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
T5531	GSK-4716	GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
T5633	H3B-5942	H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T5835	PROTAC ERRα ligand 2	PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T7223	Gestrinone	Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an...
T7644	DPN	DPN is an selective agonist of estrogen receptor β (ERβ) .
TQ0149	Prinaberel	Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
TQ0163	Sagittatoside A	Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T7839	Lasofoxifene Tartrate	Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
TQ0274	25(R)-27-hydroxy Cholesterol	27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T3399	Psoralidin	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
T7974	Lynestrenol	Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
TN1052	Lindleyin	Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
TN1148	Isopsoralenoside	Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
TN1679	Genistein 7,4'-di-O-beta-D-glucopyranoside	Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
TN1768	Iriflophenone	Standard reference
TN2200	Segetalin A	Segetalin A has estrogen-like activity.
TN1370	Allura Red AC	Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1690	Glabrene	Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
TN2045	Pelargonidin-3-O-glucoside chloride	Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-infla...
TN2288	Uralenol	Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
T8370	GSK5182	GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T12278	NXT629	NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
T12312	OP-1074	OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
T12329	Ospemifene D4	Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T14987	CMP8	CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and...
T15191	PROTAC ERRα ligand 1	PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
T13674	Elacestrant	Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .
T13675	Elacestrant dihydrochloride	Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
T11222	ERB-196	Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
T11230	ERRα antagonist-1	ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα...
T11231	ERRγ Inverse Agonist 1	ERRγ Inverse Agonist 1 is a potent, selective and orally bioavailable Estrogen-related Receptor grammar inverse agonist, with an IC50 of 40 nM.
T11399	Giredestrant	Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor ...
T13447	(R)-Zanubrutinib	(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
T16351	NSC16168	NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T13768	(+)-Medicarpin	(+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...
T12832	SAR439859	SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM f...
T4505	Ferrous Bisglycinate	Ferrous Bisglycinate is used in the fortification of infant formulations and foods.
T2810	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T7904	SR 19881	SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
T7709	(E/Z)-GSK5182	(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ)...
T6743	4-Hydroxytamoxifen	4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreven...
T5040	Medroxyprogesterone	Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.