T78646 |
Estrogen receptor antagonist 8
|
2889370-92-5
|
98%
|
|
Estrogen Receptor Antagonist 8 exhibits potent antagonistic activity against the estrogen receptor (ER), demonstrating effective anti-uterotrophic potential in v...
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T78676 |
ERα degrader 6
|
|
98%
|
|
ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM. It effectively inhibits tumor growth in...
|
T78824 |
ERD-3111
|
2832865-25-3
|
98%
|
|
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft mo...
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T79064 |
Estrogen receptor modulator 7
|
2639168-13-9
|
98%
|
|
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
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T79109 |
Estrogen receptor modulator 8
|
2170766-56-8
|
98%
|
|
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) ...
|
T79382 |
ER degrader 6
|
2922929-62-0
|
98%
|
|
ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the micro...
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T79573 |
ET receptor antagonist 1
|
|
98%
|
|
ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) ...
|
T79574 |
ET receptor antagonist 2
|
|
98%
|
|
ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH) re...
|
T79575 |
ET receptor antagonist 3
|
|
98%
|
|
"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) r...
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T79736 |
14-3-3σ/ERα stabilizer-1
|
|
98%
|
|
Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue...
|
T82439 |
Estrogen receptor modulator 10
|
2991504-90-4
|
98%
|
|
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capabili...
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T82722 |
CIDD-0149897
|
2862784-20-9
|
98%
|
|
CIDD-0149897 is a potent, selective, and brain-penetrant agonist of ERβ that exhibits antitumor activity in glioblastoma [1].
|
T9455 |
4-hydroxyestrone-4-methyl ether
|
58562-33-7
|
98%
|
|
4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) is the methylation of 4-OHE1, which is catalyzed by COMT.
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T6404 |
Bazedoxifene hydrochloride
|
198480-56-7
|
98%
|
|
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM an...
|
T6827 |
Endoxifen Z-isomer hydrochloride
|
1032008-74-4
|
98%
|
|
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
|
TN1567 |
Delphinidin chloride
|
528-53-0
|
98%
|
|
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of ...
|
TN3084 |
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
|
1353676-65-9
|
98%
|
|
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 val...
|
T9454 |
4-Hydroxyestrone
|
3131-23-5
|
98%
|
|
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
|
T9997 |
GLL 398
|
2077980-80-2
|
98%
|
|
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
|
T0760 |
Cholesterol
|
57-88-5
|
99.94%
|
|
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is w...
|