Estrogen Receptor/ERR

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.There are three human estrogen related receptors:ERRα,ERRβand ERRγ .

Cat. No.	Product name	CAS No.	Purity
T6306	Erteberel	533884-09-2	99.87%
T6306	Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T2146	Fulvestrant	129453-61-8	99.87%
T2146	Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell prolif...
T22794	G36	1392487-51-2	99.86%
T22794	G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 n...
T39710	ARV-471	2229711-68-4	99.85%
T39710	ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
T15248	Estetrol	15183-37-6	99.83%
T15248	Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver durin...
T1009	Estrone	53-16-7	99.82%
T1009	Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE direct...
T2280	Endoxifen (Z-isomer)	112093-28-4	99.81%
T2280	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T3385	Gypenoside XVII	80321-69-3	99.76%
T3385	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, act...
TN1148	Isopsoralenoside	905954-18-9	99.75%
TN1148	Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
T21387L	Nafoxidine	1845-11-0	99.74%
T21387L	Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
TN1052	Lindleyin	59282-56-3	99.74%
TN1052	Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T0593	XCT790	725247-18-7	99.74%
T0593	XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T6620	Ospemifene	128607-22-7	99.73%
T6620	Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symp...
T23540	Y134	849662-80-2	99.72%
T23540	Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11....
T4388	PHTPP	805239-56-9	99.72%
T4388	PHTPP is a selective ERβ antagonist.
T3325	Liquiritigenin	578-86-9	99.7%
T3325	Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3840	Dihydroresveratrol	58436-28-5	99.68%
T3840	Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota....
T3806	Kaempferide	491-54-3	99.66%
T3806	kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not media...
T4281	Endoxifen	110025-28-0	99.66%
T4281	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It ...
TMA1644	Segetalin B	164991-89-3	99.64%
TMA1644	Segetalin B is a natural product from Vaccaria segetalis (Neck.) Garcke, has estrogen-like activity.