FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.

Cat. No.	Product name	CAS No.	Purity
T2655	CEP-37440	1391712-60-9	99.01%
T2655	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T3041	ALK inhibitor 2	761438-38-4	99%
T3041	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T2001	PF-573228	869288-64-2	98.86%
T2001	PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
T3122	Fangchinoline	436-77-1	98.81%
T3122	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
T10285	ALK inhibitor 1	761436-81-1	98.55%
T10285	ALK inhibitor 1 is a selective ALK kinase inhibitor.
T21768	PF-562271 hydrochloride	939791-41-0	98.52%
T21768	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
T64167L	BI-853520 FA		98.40%
T64167L	BI-853520 FA (Ifebemtinib FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the stud...
T64167	Ifebemtinib	1227948-82-4	98.07%
T64167	Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule form...
T1918	NVP-TAE 226	761437-28-9	98.07%
T1918	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
T7119	Y15	4506-66-5	98%
T7119	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
T24642	YH-306	1373764-75-0	97.87%
T24642	YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T5480	BI-4464	1227948-02-8	97.43%
T5480	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T13564	AZ7550	1421373-99-0	97.07%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T24730	Roslin 2 bromide	29574-21-8	97.07%
T24730	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
T6997	SU6656	330161-87-0	97%
T6997	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
T5S0761	Nitidine chloride	13063-04-2	96.59%
T5S0761	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T2281	GSK2256098	1224887-10-8
T2281	GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
T2314	PF-431396	717906-29-1	98%
T2314	PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T77718	FAK-IN-10	491839-65-7	98%
T77718	FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
T8544	Masitinib mesylate	1048007-93-7	98%
T8544	Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...