FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
T6338	PHA-680632	398493-79-3	99.03%
T6338	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
T8541	Lenvatinib mesylate	857890-39-2	99.03%
T8541	Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.
TQ0256	FGFR4-IN-1	1708971-72-5	98.96%
TQ0256	FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).
T6024	Zoligratinib	1265229-25-1	98.94%
T6024	Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50...
T4075	Sulfatinib	1308672-74-3	98.93%
T4075	Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24...
T5122	Alofanib	1612888-66-0	98.82%
T5122	Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (I...
T7611	ODM-203	1430723-35-5	98.77%
T7611	ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
T10870L	CP-547632	252003-65-9	98.51%
T10870L	CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T1886	TAK-632	1228591-30-7	98.5%
T1886	TAK-632 is a potent pan-Raf inhibitor.
T0520	Lenvatinib	417716-92-8	98.46%
T0520	Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib h...
T2094	Danusertib	827318-97-8	98.44%
T2094	Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinase...
T3714	SUN11602	704869-38-5	98.43%
T3714	SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
T2642	PD173074	219580-11-7	98.15%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
T1975	Infigratinib	872511-34-7	98.03%
T1975	Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and ...
T3456	Fisogatinib	1707289-21-1	98%
T3456	Fisogatinib (BLU-554) is a potent inhibitor of fibroblast growth factor receptor 4 (FGFR4).
T2358	ENMD-2076	934353-76-1	98%
T2358	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T6082	SSR128129E	848318-25-2	98%
T6082	SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.
T3466	FIIN-3	1637735-84-2	97.7%
T3466	FIIN-3 is an irreversible inhibitor of FGFR.
T3274	S49076	1265965-22-7	97.4%
T3274	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
T37426	FIIN-1	1256152-35-8	97.30%
T37426	FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR...