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Metabolism Factor Xa

Factor Xa

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme  of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Tenase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Tenase ). It is therefore the first member of the final common pathway or thrombin pathway.
Cat No. product name
T0642 2-Methoxyphenothiazine 2-Methoxy Phenothiazine is light yellow or light gray solid.
T0775 Coumarin Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value a...
T1184 Rivaroxaban Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administ...
T1736 Apixaban Apixaban is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the ...
T2368 Edoxaban Tosylate Monohydrate Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T2368L Edoxaban Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T4076 Fondaparinux sodium Fondaparinux Sodium is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
T4690 Betrixaban hydrochloride(330942-05-7(free base)) Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
T4341 Betrixaban Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among...
T4980 Betrixaban maleate Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among...
T19488 O-Desmethyl apixaban sulfate sodium O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
T12736 Rivaroxaban D4 Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
T12782 RWJ-445167 RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
2-Methoxyphenothiazine
T0642CAS 1771-18-2
2-Methoxy Phenothiazine is light yellow or light gray solid.
Coumarin
T0775CAS 91-64-5
Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value a...
Rivaroxaban
T1184CAS 366789-02-8
Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administ...
Apixaban
T1736CAS 503612-47-3
Apixaban is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the ...
Edoxaban Tosylate Monohydrate
T2368CAS 1229194-11-9
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Edoxaban
T2368LCAS 912273-65-5
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Fondaparinux sodium
T4076CAS 114870-03-0
Fondaparinux Sodium is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
Betrixaban hydrochloride(330942-05-7(free base))
T4690CAS T4690
Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
Betrixaban
T4341CAS 330942-05-7
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among...
Betrixaban maleate
T4980CAS 936539-80-9
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among...
O-Desmethyl apixaban sulfate sodium
T19488CAS
O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
Rivaroxaban D4
T12736CAS 1132681-38-9
Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
RWJ-445167
T12782CAS 226566-43-4
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.