T0686 |
Orlistat |
Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor. |
T0846 |
L(-)-Carnitine |
L(-)-Carnitine is an amino acid derivative. L(-)-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and ...
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T0988 |
Trimetazidine dihydrochloride |
Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-isc...
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T1426 |
Pyrazinamide |
Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative. |
T2468 |
A 769662 |
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM). |
T4380 |
Ac-CoA Synthase Inhibitor1 |
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). |
TJS0387 |
Deoxyrhapontin |
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this co...
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TQ0260 |
Cerulenin |
Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus. |
T7947 |
FT113 |
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity |
TN1365 |
Albaspidin AP |
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promis...
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TN1751 |
Hydroxycitric acid |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to a...
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TN1803 |
Isoscoparin |
Isoscoparin has antioxidant, and anti-adipogenic effects, it may be a potential therapeutic agent for the prevention and treatment of obesity. Isoscoparin can s...
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TN2083 |
Pinostrobin chalcone |
Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through t...
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TN1440 |
Beta-Hydroxyisovalerylshikonin |
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
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T10656 |
trans-C75 |
trans-C75 is an enantiomer of C75. C75 is an inhibitor of fatty acid synthase (FASN). |
T14298 |
Rimiducid |
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch. And it rapidly i...
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T14570 |
BI99179 |
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cen...
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T11266L |
FAS-IN-1 Tosylate |
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM. |
TN2535 |
1-Hydroxy-2-oxopomolic acid |
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression. |
TN4094 |
Gallocatechin gallate |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
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