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Search Result

Search Results for " fatty-acid-synthase "

Targets

Fatty Acid Synthase

46

Compounds

13

Natural Products

9

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T11557 FASN-IN-3 Fatty Acid Synthase
FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
T0686 Orlistat Ro-18-0647,Tetrahydrolipstatin Apoptosis , Others , Fatty Acid Synthase
Orlistat (Tetrahydrolipstatin) is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.
T7947 FT113 Fatty Acid Synthase
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
T17181 TVB-3664 Fatty Acid Synthase
TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthe...
T17180 TVB-3166 Apoptosis , Others , Fatty Acid Synthase
TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis,...
T7798 FGH10019 FGH-10019 NPC1L1 , Fatty Acid Synthase
FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
T11267 FASN-IN-1 TVB-2460 Fatty Acid Synthase
FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzyme involved in fatty acid synthesis, potentially disrupting fatt...
T9266 Fatostatin Lipid , Fatty Acid Synthase
Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.
T12437 PF429242 dihydrochloride S1P Receptor
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T36841 IPI-9119 Fatty Acid Synthase
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
T10656 Trans-C75 (±)-C75 Others , Fatty Acid Synthase
trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
T15271 Denifanstat FASN-IN-2,TVB2640,TVB-2640 Fatty Acid Synthase
Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
T6832 Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin NPC1L1 , Fatty Acid Synthase
Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
T10657 C75 C-75 Fatty Acid Synthase
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).
T15429 GSK2194069 Others , NADPH , Fatty Acid Synthase
GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer c...
T21831 UCM05 G28UCM Fatty Acid Synthase
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including in cell lines resistant to anti-HER2 drugs [1]. Additionally, it functions as an inhibito...
T26458 A 9145C A9145C,A-9145C
A 9145C is an inhibitor of RNA methylase and cyclopropane fatty acid synthase.
T11266L FAS-IN-1 Tosylate Fatty Acid Synthase
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
T11266 FASN-IN-4 FAS-IN-1 Others
FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM.
T29343 2-Decenoic acid Dec-2-enoic acid
trans-Dec-2-enoic acid is an intermediate in fatty acid biosynthesis. Specifically, trans-Dec-2-enoic is converted from (R)-3-Hydroxydecanoic acid via enzyme, fatty-acid Synthase (EC:2. 3. 1. 85).
T11574 HS79 Others
HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids (IC50: 1.57 μM).
T27495 GSK951A
GSK951A is an inhibitor of EchA6. GSK951A interacts with fatty acid synthase II (FAS-II), inhibits mycolic acid biosynthesis and suppresses the synthesis of all classes of MAMES in M. bovis BCG, whilst the FAMEs remain l...
T14570 BI 99179 BI99179 Fatty Acid Synthase
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
T11575 HS80 Others
HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids (IC50: 7.13 μM).
T35634 Platensimycin
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synt...
T37776 FASN-IN-4 tosylate
FASN-IN-4 tosylate is a potent fatty acid synthase (FASN) inhibitor, exhibiting an IC50 value of 10 nM. Additionally, it demonstrates inhibitory activity against SARS-CoV-2, with an EC50 of 18.6 nM [2].
T36045 1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also b...
T64276 Octanoyl coenzyme A lithium
Octanoyl coenzyme A lithium is a derivative of the fatty acid acyl coenzyme A. Octanoyl coenzyme A lithium inhibits citrate synthase and glutamate dehydrogenase (IC50: 0.4-1.6 mM).
T35697 Lauric Acid-13C
Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Laur...
T37405 Octanoyl Coenzyme A (sodium salt)
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β...
T70978 5-Hydroxy Lansoprazole Sulfide
5-Hydroxy Lansoprazole Sulfide is an inhibitor of fatty acid synthase (FASN). FASN, which is responsible for de-novo synthesis of lipids, has been found to be overexpressed in cancerous tissue. 5-Hydroxy Lansoprazole Sul...
T37867 9(S)-HpOTrE
9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found...
T38208 Heneicosapentaenoic Acid
Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one...
T12342 P053 Others
P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor with an IC50 of 0.5 μM. P053 is an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulator of whole-body ad...
T37270 9(E),11(E)-12-nitro Conjugated Linoleic Acid
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combinat...
T78872 CTL-06
CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating...
T78873 CTL-12
CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apo...
T38389 Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The ...
T70882 Orlistat-d3
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase doma...
T35791 Palmitic acid-13C
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid i...
T35789 Palmitic acid-1-13C
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plas...
T37743 N-octadecanoyl-L-Homoserine lactone
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm forma...
T35979 Benastatin C
Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Be...
T36130 22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc...
T35978 Benastatin A
Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benast...
T37741 N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm fo...

Compounds

FASN-IN-3
T11557
Synonym:
Target: Fatty Acid Synthase
Orlistat
T0686
Synonym: Ro-18-0647,Tetrahydrolipstatin
Target: Apoptosis, Others, Fatty Acid Synthase
FT113
T7947
Synonym:
Target: Fatty Acid Synthase
TVB-3664
T17181
Synonym:
Target: Fatty Acid Synthase
TVB-3166
T17180
Synonym:
Target: Apoptosis, Others, Fatty Acid Synthase
FGH10019
T7798
Synonym: FGH-10019
Target: NPC1L1, Fatty Acid Synthase
FASN-IN-1
T11267
Synonym: TVB-2460
Target: Fatty Acid Synthase
Fatostatin
T9266
Synonym:
Target: Lipid, Fatty Acid Synthase
PF429242 dihydrochloride
T12437
Synonym:
Target: S1P Receptor
IPI-9119
T36841
Synonym:
Target: Fatty Acid Synthase
trans-C75
T10656
Synonym: (±)-C75
Target: Others, Fatty Acid Synthase
Denifanstat
T15271
Synonym: FASN-IN-2,TVB2640,TVB-2640
Target: Fatty Acid Synthase
Fatostatin hydrobromide
T6832
Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin
Target: NPC1L1, Fatty Acid Synthase
C75
T10657
Synonym: C-75
Target: Fatty Acid Synthase
GSK2194069
T15429
Synonym:
Target: Others, NADPH, Fatty Acid Synthase
UCM05
T21831
Synonym: G28UCM
Target: Fatty Acid Synthase
A 9145C
T26458
Synonym: A9145C,A-9145C
Target:
FAS-IN-1 Tosylate
T11266L
Synonym:
Target: Fatty Acid Synthase
FASN-IN-4
T11266
Synonym: FAS-IN-1
Target: Others
2-Decenoic acid
T29343
Synonym: Dec-2-enoic acid
Target:
HS79
T11574
Synonym:
Target: Others
GSK951A
T27495
Synonym:
Target:
BI 99179
T14570
Synonym: BI99179
Target: Fatty Acid Synthase
HS80
T11575
Synonym:
Target: Others
Platensimycin
T35634
Synonym:
Target:
FASN-IN-4 tosylate
T37776
Synonym:
Target:
1a,1b-dihomo Prostaglandin E2
T36045
Synonym: 1a,1b-dihomo Prostaglandin E2
Target:
Octanoyl coenzyme A lithium
T64276
Synonym:
Target:
Lauric Acid-13C
T35697
Synonym:
Target:
Octanoyl Coenzyme A (sodium salt)
T37405
Synonym:
Target:
5-Hydroxy Lansoprazole Sulfide
T70978
Synonym:
Target:
9(S)-HpOTrE
T37867
Synonym:
Target:
Heneicosapentaenoic Acid
T38208
Synonym:
Target:
P053
T12342
Synonym:
Target: Others
9(E),11(E)-12-nitro Conjugated Linoleic Acid
T37270
Synonym:
Target:
CTL-06
T78872
Synonym:
Target:
CTL-12
T78873
Synonym:
Target:
Prostaglandin D2 Ethanolamide
T38389
Synonym: Prostaglandin D2 Ethanolamide
Target:
Orlistat-d3
T70882
Synonym:
Target:
Palmitic acid-13C
T35791
Synonym:
Target:
Palmitic acid-1-13C
T35789
Synonym:
Target:
N-octadecanoyl-L-Homoserine lactone
T37743
Synonym:
Target:
Benastatin C
T35979
Synonym:
Target:
22(S)-hydroxy Cholesterol
T36130
Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
Target:
Benastatin A
T35978
Synonym:
Target:
N-hexadecanoyl-L-Homoserine lactone
T37741
Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
Target:
Cat No. Product Name Synonyms Targets
TQ0260 Cerulenin Antibiotic , Antifungal , Fatty Acid Synthase
Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
T2824 Pedunculoside Others , Fatty Acid Synthase
Pedunculoside is extracted from Ilex rotunda Thunb.
T5S0246 Pseudoprotodioscin Others , Fatty Acid Synthase
1. Pseudoprotodioscin has moderate cytotoxicity.
TJS0387 Desoxyrhaponticin Deoxyrhapontin,Deoxyrhaponticin Apoptosis , Fatty Acid Synthase
1. Desoxyrhaponticin (Deoxyrhaponticin) is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least...
T3121 Betulin Trochol,betulinic alcohol,betuline,betulinol,Betulol Apoptosis , Endogenous Metabolite , Lipid , Fatty Acid Synthase
Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is fo...
T3324 Lycorine Galanthidine,Narcissine,Amarylline,Belamarine,Licorine Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T3322 Trans-Chalcone Chalcone,Cinnamophenone,Chalkone Apoptosis , Others , Antifungal , Fatty Acid Synthase
trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
T4S1173 Agrimol B Sirtuin , PPAR
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T4S1421 Praeruptorin B Praeruptorin D NPC1L1 , Fatty Acid Synthase
Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.
T2835 Morin Toxylon pomiferum,Aurantica,Calico Yellow,Al-Morin Others
Morin (Calico Yellow) was found to be a weak inhibitor of fatty acid synthase (IC50: 2.33 μM). Morin is a yellow color substance that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) a...
T4S0800 Demethyleneberberine P450 , NOS , NF-κB , HIF , AMPK
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...
T29091 Valilactone (-)-Valilactone
Valilactone is a fatty acid synthase inhibitor, which is produced by a cultured strain of soil actinomycetes.
TN1365 Albaspidin AP Fatty Acid Synthase
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inhibitors, and FAS is emerging as a potent...

Natural Products

Cerulenin
TQ0260
Synonym:
Target: Antibiotic, Antifungal, Fatty Acid Synthase
Pedunculoside
T2824
Synonym:
Target: Others, Fatty Acid Synthase
Pseudoprotodioscin
T5S0246
Synonym:
Target: Others, Fatty Acid Synthase
Desoxyrhaponticin
TJS0387
Synonym: Deoxyrhapontin,Deoxyrhaponticin
Target: Apoptosis, Fatty Acid Synthase
Betulin
T3121
Synonym: Trochol,betulinic alcohol,betuline,betulinol,Betulol
Target: Apoptosis, Endogenous Metabolite, Lipid, Fatty Acid Synthase
Lycorine
T3324
Synonym: Galanthidine,Narcissine,Amarylline,Belamarine,Licorine
Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase
trans-Chalcone
T3322
Synonym: Chalcone,Cinnamophenone,Chalkone
Target: Apoptosis, Others, Antifungal, Fatty Acid Synthase
Agrimol B
T4S1173
Synonym:
Target: Sirtuin, PPAR
Praeruptorin B
T4S1421
Synonym: Praeruptorin D
Target: NPC1L1, Fatty Acid Synthase
Morin
T2835
Synonym: Toxylon pomiferum,Aurantica,Calico Yellow,Al-Morin
Target: Others
Demethyleneberberine
T4S0800
Synonym:
Target: P450, NOS, NF-κB, HIF, AMPK
Valilactone
T29091
Synonym: (-)-Valilactone
Target:
Albaspidin AP
TN1365
Synonym:
Target: Fatty Acid Synthase

Recombinant Proteins

Species：
Staphylococcus aureus (4)
Human (2)
E. coli (1)
Mouse (1)
Saccharomyces cerevisiae (1)
Expression System：
E. coli (8)
Yeast (1)
Tag：
His (2)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
N-terminal 6xHis-SUMO-tagged (2)
N-terminal 10xHis-tagged (1)
N-terminal 6xHis-tagged (1)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPY-06686 FASN Protein, Mouse, Recombinant (His) Mouse E. coli
FASN Protein, Mouse, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 34.23 kDa. Accession number: P19096
TMPY-06683 FASN Protein, Human, Recombinant (His) Human E. coli
FASN Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 35.26 kDa. Accession number: P49327
TMPH-03520 ACP Protein, S. aureus, Recombinant (His & SUMO) Staphylococcus aureus E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
TMPH-03519 ACP Protein, S. aureus, Recombinant (His) Staphylococcus aureus Yeast
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
TMPH-00572 ACP Protein, E. coli, Recombinant (His & SUMO) E. coli E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
TMPH-03518 ACP Protein, S. aureus, Recombinant (GST) Staphylococcus aureus E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced.
TMPH-03448 EHT1 Protein, S. cerevisiae, Recombinant (His) Saccharomyces cerevisiae E. coli
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by est...
TMPH-03524 KAS III Protein, S. aureus, Recombinant (His & Myc) Staphylococcus aureus E. coli
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may ther...
TMPH-01634 MLYCD Protein, Human, Recombinant (His & Myc) Human E. coli
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid syn...
Cat No. Product Name
L2510 Lipid Metabolism Compound Library

496 compounds
A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).

Libraries

Lipid Metabolism Compound Library
L2510
Compounds: 496
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