Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.

Cat. No.	Product name	CAS No.	Purity
T2824	Pedunculoside	42719-32-4	99.13%
T2824	Pedunculoside is extracted from Ilex rotunda Thunb.
T21831	UCM05	1094451-90-7	99.11%
T21831	UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including in cell lines resistant to ant...
T17181	TVB-3664	2097262-58-1	99.06%
T17181	TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50...
T7798	FGH10019	1046045-61-7	98.93%
T7798	FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
T10657	C75	218137-86-1	98.84%
T10657	C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).
T10656	Trans-C75	191282-48-1	98.79%
T10656	trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
T2468	A-769662	844499-71-4	98.72%
T2468	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T3324	Lycorine	476-28-8	98.71%
T3324	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T9732	VY-3-135	1824637-41-3	98.56%
T9732	VY-3-135 is a metastasis inhibitor and an acetyl-CoA synthetase 2 (ACSS2) modulator.
T11267	FASN-IN-1	1808260-84-5	98.23%
T11267	FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzyme in...
T11557	FASN-IN-3	2097262-60-5	98.22%
T11557	FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	98.16%
TN1440	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor ...
T5S0246	Pseudoprotodioscin	102115-79-7	98%
T5S0246	1. Pseudoprotodioscin has moderate cytotoxicity.
TN1803	Isoscoparin	20013-23-4	97.95%
TN1803	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T7947	FT113	1630808-89-7	97.68%
T7947	FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
T3S1701	Dihydrocurcumin	76474-56-1	97.23%
T3S1701	Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
T21724L	Fas C-Terminal Tripeptide Acetate	T21724L
T21724L	Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
T27307	Fasnall	929978-58-5	98%
T27307	Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
T3121	Betulin	473-98-3	98%
T3121	Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it fo...
TQ0260	Cerulenin	17397-89-6	98%
TQ0260	Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.