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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1482 Ciclopirox 29342-05-0 99.41%
Ciclopirox
Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-...
T0326L L-Glutamine 56-85-9 99.36%
L-Glutamine
L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T3170 Troglitazone 97322-87-7 99.36%
Troglitazone
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T2988 (-)-Epigallocatechin Gallate 989-51-5 99.34%
(-)-Epigallocatechin Gallate
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG...
T1622 Rosiglitazone maleate 155141-29-0 99.33%
Rosiglitazone maleate
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplas...
T39520 Vamifeport 2095668-10-1 99.26%
Vamifeport
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 i...
T3646 RSL3 1219810-16-8 99.23%
RSL3
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
TJS2190 Nordihydroguaiaretic acid 500-38-9 99.2%
Nordihydroguaiaretic acid
Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ...
T0093 Sorafenib tosylate 475207-59-1 99.2%
Sorafenib tosylate
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
TMA2394 DL-alpha-Tocopherol 10191-41-0 99.19%
DL-alpha-Tocopherol
DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.
T1922 Pseudolaric Acid B 82508-31-4 99.19%
Pseudolaric Acid B
Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
THS1455 DihydroarteMisinic acid 85031-59-0 99.14%
DihydroarteMisinic acid
DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal he...
T0672 Pravastatin sodium 81131-70-6 99.08%
Pravastatin sodium
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T19467 NADPH tetracyclohexanamine 100929-71-3 99.05%
NADPH tetracyclohexanamine
NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.
T0875 Acetylcysteine 616-91-1 98.98%
Acetylcysteine
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
T1516 Curcumin 458-37-7 98.98%
Curcumin
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
T1114 Ciclopirox olamine 41621-49-2 98.97%
Ciclopirox olamine
Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T6165 Bardoxolone Methyl 218600-53-4 98.94%
Bardoxolone Methyl
Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-t...
T4360 ML385 846557-71-9 98.88%
ML385
ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhib...
T0907 Sulfasalazine 599-79-1 98.73%
Sulfasalazine
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
Ciclopirox
T1482
Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-...
L-Glutamine
T0326L
L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
Troglitazone
T3170
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
(-)-Epigallocatechin Gallate
T2988
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG...
Rosiglitazone maleate
T1622
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplas...
Vamifeport
T39520
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 i...
RSL3
T3646
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
Nordihydroguaiaretic acid
TJS2190
Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ...
Sorafenib tosylate
T0093
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
DL-alpha-Tocopherol
TMA2394
DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.
Pseudolaric Acid B
T1922
Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
DihydroarteMisinic acid
THS1455
DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal he...
Pravastatin sodium
T0672
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
NADPH tetracyclohexanamine
T19467
NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.
Acetylcysteine
T0875
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
Curcumin
T1516
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
Ciclopirox olamine
T1114
Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
Bardoxolone Methyl
T6165
Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-t...
ML385
T4360
ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhib...
Sulfasalazine
T0907
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
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TargetMol