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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1502 Vildagliptin 274901-16-5 98%
Vildagliptin
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cy...
T5679 (E)-Ferulic acid 537-98-4 98%
(E)-Ferulic acid
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of ...
T5364 TBHQ 1948-33-0 98%
TBHQ
TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
T4066 FIN56 1083162-61-1 97.86%
FIN56
FIN56 is a specific inducer of ferroptosis.
T16540 Piperazine Erastin 1538593-71-3 97.74%
Piperazine Erastin
Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
T2858 Baicalein 491-67-8 97.25%
Baicalein
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
T6947 Piperlongumine 20069-09-4 97.21%
Piperlongumine
Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (RO...
T8375 ML-210 1360705-96-9 97%
ML-210
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T0392 Artemisinin 63968-64-9 97%
Artemisinin
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
T6243 U-73122 112648-68-7 96.73%
U-73122
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T2870 Matrine 519-02-8 100%
Matrine
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T0935 Butylated hydroxytoluene 128-37-0 100%
Butylated hydroxytoluene
Butylated hydroxytoluene (BHT FCC/NF) is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6. Butylated hydroxyto...
T1847 Necrostatin-1 4311-88-0 100%
Necrostatin-1
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
T0875 Acetylcysteine 616-91-1 100%
Acetylcysteine
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
T0214L Pioglitazone hydrochloride 112529-15-4 100%
Pioglitazone hydrochloride
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic ac...
T6954 PRIMA-1 5608-24-2
PRIMA-1
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
T0326 DL-Glutamine 6899-04-3
DL-Glutamine
DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processe...
T20819 Ammonium iron(III) citrate 1185-57-5
Ammonium iron(III) citrate
Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellul...
T77762 ROS-generating agent 1 2369030-41-9 98%
ROS-generating agent 1
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular T...
T77765 FSEN1 862808-01-3 98%
FSEN1
FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 induces iron death in cancer cells by inhibiting FSP1. F...
Vildagliptin
T1502
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cy...
(E)-Ferulic acid
T5679
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of ...
TBHQ
T5364
TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
FIN56
T4066
FIN56 is a specific inducer of ferroptosis.
Piperazine Erastin
T16540
Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
Baicalein
T2858
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
Piperlongumine
T6947
Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (RO...
ML-210
T8375
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
Artemisinin
T0392
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
U-73122
T6243
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
Matrine
T2870
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
Butylated hydroxytoluene
T0935
Butylated hydroxytoluene (BHT FCC/NF) is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6. Butylated hydroxyto...
Necrostatin-1
T1847
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
Acetylcysteine
T0875
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
Pioglitazone hydrochloride
T0214L
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic ac...
PRIMA-1
T6954
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
DL-Glutamine
T0326
DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processe...
Ammonium iron(III) citrate
T20819
Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellul...
ROS-generating agent 1
T77762
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular T...
FSEN1
T77765
FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 induces iron death in cancer cells by inhibiting FSP1. F...
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TargetMol