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Membrane transporter/Ion channel GABA Receptor

GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Cat No. product name
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0028 4-Amino-3-hydroxybutyric Acid Agent for improving learning or memory [US6803366]Gamma Hydroxybutyric Acid, commonly abbreviated GHB, is an illegal therapeutic drug in multiple countries. In ...
T0048 Corvotone Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth ce...
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0128 Vigabatrin Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate transaminase responsible for the catabolism of γ-aminobuty...
T0169 Nefiracetam Nefiracetam are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced ...
T0508 4-Aminobutyric acid 4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
T0883 Homotaurine Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties.
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T0958 Penicillin G sodium salt Penicillin G sodium is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is eff...
T1065 Baclofen Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen ac...
T1089 Etomidate Etomidate is a GABAA receptor agonist, with a short-acting sedative, hypnotic, and general anesthetic properties.
T1128 Oxiracetam Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments.
T1240 Flumazenil Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS)...
T1396 Bemegrid Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
T1413 Pentetrazol Pentylenetetrazol is a GABA(A) receptor antagonist, that displays activity as a central nervous system and respiratory stimulant.
T1602 Valproic acid sodium salt Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in bl...
T1673 Acamprosate calcium Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.
T1860 AWD 131-138 AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models.
T2067 NS 11394 NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) >...
T2196 Fipronil Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect centra...
T2339 Apalutamide Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T2407 Tiagabine Tiagabine is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T2749 Ginkgolide A Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of in...
T2775 Baicalin Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
T2850 (+)-Bicuculline Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolate...
T2990 Phenibut Phenibut is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).
T2998 Dihydromyricetin Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of...
T3318 Wogonoside Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
T3644 U93631 GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of G...
T4176 rac-BHFF Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respective...
T6355 (R)-baclofen (R)-baclofena, a derivative of gamma-aminobutyric acid,is commonly utilized for the treatment of spasticity.
T6507 Gabapentin HCl Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
T7000 Tiagabine hydrochloride Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric ac...
T4440 Saclofen Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: ...
T4363 CGP 52432 CGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM).
T3S2259 Methyl eugenol 1. Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carci...
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
T3927 Phellopterin Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration ...
T4522 SSD114 hydrochloride SSD114 is a novel GABAB receptor positive allosteric modulator.
T4688 Pipequaline hydrochloride Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure ...
T4655 Pipequaline Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure ...
T4682 Allopregnanolone Allopregnanolone is under investigation for the treatment of Super-Refractory Status Epilepticus.Allopregnanolone has been investigated for the treatment of Sev...
T4993 Afloqualone Afloqualone is a agonist of GABA receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. Afloqualone is an analogue of ...
T5330 Fluralaner Fluralaner is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes...
T5375 Loreclezole Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
T0702 Gabapentin Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
T0627 beta-Alanine β-Alanine is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activatin...
T5734 (+)-BORNEOL (+)-BORNEOL is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of...
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
4-Amino-3-hydroxybutyric Acid
T0028CAS 924-49-2
Agent for improving learning or memory [US6803366]Gamma Hydroxybutyric Acid, commonly abbreviated GHB, is an illegal therapeutic drug in multiple countries. In ...
Corvotone
T0048CAS 59-26-7
Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth ce...
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Vigabatrin
T0128CAS 60643-86-9
Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate transaminase responsible for the catabolism of γ-aminobuty...
Nefiracetam
T0169CAS 77191-36-7
Nefiracetam are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced ...
4-Aminobutyric acid
T0508CAS 56-12-2
4-Aminobutyric acid is the most common inhibitory neurotransmitter in the central nervous system.
Topiramate
T0675CAS 97240-79-4
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
Homotaurine
T0883CAS 3687-18-1
Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties.
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
Penicillin G sodium salt
T0958CAS 69-57-8
Penicillin G sodium is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is eff...
Baclofen
T1065CAS 1134-47-0
Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen ac...
Etomidate
T1089CAS 33125-97-2
Etomidate is a GABAA receptor agonist, with a short-acting sedative, hypnotic, and general anesthetic properties.
Oxiracetam
T1128CAS 62613-82-5
Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments.
Flumazenil
T1240CAS 78755-81-4
Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS)...
Bemegrid
T1396CAS 64-65-3
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
Pentetrazol
T1413CAS 54-95-5
Pentylenetetrazol is a GABA(A) receptor antagonist, that displays activity as a central nervous system and respiratory stimulant.
Valproic acid sodium salt
T1602CAS 1069-66-5
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in bl...
Acamprosate calcium
T1673CAS 77337-73-6
Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.
AWD 131-138
T1860CAS 188116-07-6
AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models.
NS 11394
T2067CAS 951650-22-9
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) >...
Fipronil
T2196CAS 120068-37-3
Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect centra...
Apalutamide
T2339CAS 956104-40-8
Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
Tiagabine
T2407CAS 115103-54-3
Tiagabine is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
Ginkgolide A
T2749CAS 15291-75-5
Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of in...
Baicalin
T2775CAS 21967-41-9
Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
(+)-Bicuculline
T2850CAS 485-49-4
Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolate...
Phenibut
T2990CAS 1078-21-3
Phenibut is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Dihydromyricetin
T2998CAS 27200-12-0
Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of...
Wogonoside
T3318CAS 51059-44-0
Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
U93631
T3644CAS 152273-12-6
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of G...
rac-BHFF
T4176CAS 123557-91-5
Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respective...
(R)-baclofen
T6355CAS 69308-37-8
(R)-baclofena, a derivative of gamma-aminobutyric acid,is commonly utilized for the treatment of spasticity.
Gabapentin HCl
T6507CAS 60142-95-2
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
Tiagabine hydrochloride
T7000CAS 145821-59-6
Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric ac...
Saclofen
T4440CAS 125464-42-8
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: ...
CGP 52432
T4363CAS 139667-74-6
CGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM).
Methyl eugenol
T3S2259CAS 93-15-2
1. Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carci...
Valproic Acid
T7064CAS 99-66-1
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
Phellopterin
T3927CAS 2543-94-4
Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration ...
SSD114 hydrochloride
T4522CAS T4522
SSD114 is a novel GABAB receptor positive allosteric modulator.
Pipequaline hydrochloride
T4688CAS 80221-58-5
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure ...
Pipequaline
T4655CAS 77472-98-1
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure ...
Allopregnanolone
T4682CAS 516-54-1
Allopregnanolone is under investigation for the treatment of Super-Refractory Status Epilepticus.Allopregnanolone has been investigated for the treatment of Sev...
Afloqualone
T4993CAS 56287-74-2
Afloqualone is a agonist of GABA receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. Afloqualone is an analogue of ...
Fluralaner
T5330CAS 864731-61-3
Fluralaner is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes...
Loreclezole
T5375CAS 117857-45-1
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
Gabapentin
T0702CAS 60142-96-3
Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
beta-Alanine
T0627CAS 107-95-9
β-Alanine is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activatin...
(+)-BORNEOL
T5734CAS 464-43-7
(+)-BORNEOL is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of...