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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16489 Darigabat 1614245-70-3 98%
Darigabat
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki...
T24381 L-822179 215874-86-5 98%
L-822179
L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
T5330 Fluralaner 864731-61-3 98%
Fluralaner
Fluralaner (A1443) is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head me...
TN1308 6-Hydroxyflavanone 4250-77-5 98%
6-Hydroxyflavanone
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
T2067 NS11394 951650-22-9 98%
NS11394
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1...
T4993 Afloqualone 56287-74-2 98%
Afloqualone
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and mu...
T3644 U93631 152273-12-6 98%
U93631
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GAB...
T3173 DAA-1106 220551-92-8 98%
DAA-1106
DAA-1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine...
TQ0151 L-655708 130477-52-0 98%
L-655708
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
T1240 Flumazenil 78755-81-4 98%
Flumazenil
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous ...
T37190 L-Allylglycine 16338-48-0 98%
L-Allylglycine
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
T32098L Homocarnosine acetate 98%
Homocarnosine acetate
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-infla...
T8268 6,2'-Dihydroxyflavone 92439-20-8 98%
6,2'-Dihydroxyflavone
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
T16539 Piperazine citrate 144-29-6 98%
Piperazine citrate
Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmi...
TMS0418 Dihydroergotoxine mesylate 8067-24-1 98%
Dihydroergotoxine mesylate
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.
T28479 PZ-II-029 164025-44-9 98%
PZ-II-029
PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
T21793 CGP 35348 123690-79-9 98%
CGP 35348
CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after n...
Darigabat
T16489
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki...
L-822179
T24381
L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
Fluralaner
T5330
Fluralaner (A1443) is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head me...
6-Hydroxyflavanone
TN1308
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
NS11394
T2067
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1...
Afloqualone
T4993
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and mu...
U93631
T3644
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GAB...
DAA-1106
T3173
DAA-1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine...
L-655708
TQ0151
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
Flumazenil
T1240
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous ...
L-Allylglycine
T37190
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
Homocarnosine acetate
T32098L
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-infla...
6,2'-Dihydroxyflavone
T8268
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
Piperazine citrate
T16539
Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmi...
Dihydroergotoxine mesylate
TMS0418
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.
PZ-II-029
T28479
PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
CGP 35348
T21793
CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after n...
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TargetMol